UHRF1 depletion causes a G2/M arrest, activation of DNA damage response and apoptosis. - Wikidata - awgldk - TriplyDB

UHRF1 depletion causes a G2/M arrest, activation of DNA damage response and apoptosis.

UHRF1 depletion causes a G2/M arrest, activation of DNA damage response and apoptosis.

http://www.wikidata.org/entity/Q39610946

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PHD finger recognition of unmodified histone H3R2 links UHRF1 to regulation of euchromatic gene expression NIRF/UHRF2 occupies a central position in the cell cycle network and allows coupling with the epigenetic landscape TCR affinity associated with functional differences between dominant and subdominant SIV epitope-specific CD8+ T cells in Mamu-A*01+ rhesus monkeys DNA methylation, its mediators and genome integrity Overexpression of UHRF1 gene correlates with the major clinicopathological parameters in urinary bladder cancer.Aronia melanocarpa juice induces a redox-sensitive p73-related caspase 3-dependent apoptosis in human leukemia cells.Down-regulation of UHRF1, associated with re-expression of tumor suppressor genes, is a common feature of natural compounds exhibiting anti-cancer properties DNA hypomethylation induces a DNA replication-associated cell cycle arrest to block hepatic outgrowth in uhrf1 mutant zebrafish embryos Uhrf2 is important for DNA damage response in vascular smooth muscle cells.Bilberry extract (Antho 50) selectively induces redox-sensitive caspase 3-related apoptosis in chronic lymphocytic leukemia cells by targeting the Bcl-2/Bad pathway.UHRF1 phosphorylation by cyclin A2/cyclin-dependent kinase 2 is required for zebrafish embryogenesis.A cell cycle-dependent BRCA1-UHRF1 cascade regulates DNA double-strand break repair pathway choice Transcription factor ICBP90 regulates the MIF promoter and immune susceptibility locus.UHRF1 regulation of the Keap1-Nrf2 pathway in pancreatic cancer contributes to oncogenesis Long noncoding RNA UPAT promotes colon tumorigenesis by inhibiting degradation of UHRF1.Zebrafish models of human liver development and disease Limoniastrum guyonianum aqueous gall extract induces apoptosis in human cervical cancer cells involving p16 INK4A re-expression related to UHRF1 and DNMT1 down-regulation.The mutational landscape of adenoid cystic carcinoma UHRF1 gene silencing inhibits cell proliferation and promotes cell apoptosis in human cervical squamous cell carcinoma CaSki cells.UHRF1 overexpression drives DNA hypomethylation and hepatocellular carcinoma Elevated UHRF1 expression contributes to poor prognosis by promoting cell proliferation and metastasis in hepatocellular carcinoma.Epigenetics, development, and cancer: zebrafish make their mark..The Roles of the Methyl-CpG Binding Proteins in Cancer.The lure of zebrafish in liver research: regulation of hepatic growth in development and regeneration.MiR-124 exerts tumor suppressive functions on the cell proliferation, motility and angiogenesis of bladder cancer by fine-tuning UHRF1.Luteolin induces apoptosis in BE colorectal cancer cells by downregulating calpain, UHRF1, and DNMT1 expressions.DNA damage regulates UHRF1 stability via the SCF(β-TrCP) E3 ligase.Loss of Uhrf1 in neural stem cells leads to activation of retroviral elements and delayed neurodegeneration.The epigenetic integrator UHRF1: on the road to become a universal biomarker for cancer.UHRF1 coordinates peroxisome proliferator activated receptor gamma (PPARG) epigenetic silencing and mediates colorectal cancer progression.Gene therapy with RNAi targeting UHRF1 driven by tumor-specific promoter inhibits tumor growth and enhances the sensitivity of chemotherapeutic drug in breast cancer in vitro and in vivo.Anti-neoplastic agent thymoquinone induces degradation of α and β tubulin proteins in human cancer cells without affecting their level in normal human fibroblasts.Regulation of Ubiquitin-like with Plant Homeodomain and RING Finger Domain 1 (UHRF1) Protein Stability by Heat Shock Protein 90 Chaperone Machinery.PPARG Epigenetic Deregulation and Its Role in Colorectal Tumorigenesis.UHRF1 is an Independent Prognostic Factor and a Potential Therapeutic Target of Esophageal Squamous Cell Carcinoma.UHRF1 depletion sensitizes retinoblastoma cells to chemotherapeutic drugs via downregulation of XRCC4.Globular adiponectin inhibits leptin-stimulated esophageal adenocarcinoma cell proliferation via adiponectin receptor 2-mediated suppression of UHRF1.The correlation between miR-146a C/G polymorphism and UHRF1 gene expression level in gastric tumor.Systematic detection of positive selection in the human-pathogen interactome and lasting effects on infectious disease susceptibility.The Extract of Leonurus sibiricus Transgenic Roots with AtPAP1 Transcriptional Factor Induces Apoptosis via DNA Damage and Down Regulation of Selected Epigenetic Factors in Human Cancer Cells.

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P2860

UHRF1 depletion causes a G2/M arrest, activation of DNA damage response and apoptosis.

http://www.wikidata.org/entity/Q39610946

description

2011 nî lūn-bûn

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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2011年论文

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2011年论文

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name

UHRF1 depletion causes a G2/M arrest, activation of DNA damage response and apoptosis.

@en

UHRF1 depletion causes a G2/M arrest, activation of DNA damage response and apoptosis.

@nl

type

label

UHRF1 depletion causes a G2/M arrest, activation of DNA damage response and apoptosis.

@en

UHRF1 depletion causes a G2/M arrest, activation of DNA damage response and apoptosis.

@nl

prefLabel

UHRF1 depletion causes a G2/M arrest, activation of DNA damage response and apoptosis.

@en

UHRF1 depletion causes a G2/M arrest, activation of DNA damage response and apoptosis.

@nl

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UHRF1 depletion causes a G2/M arrest, activation of DNA damage response and apoptosis.

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P2093

Amy L Tien

http://www.w3.org/2001/XMLSchema#string

Atul Kulkarni

http://www.w3.org/2001/XMLSchema#string

Bernadette Goudreau

http://www.w3.org/2001/XMLSchema#string

Chinweike Ukomadu

http://www.w3.org/2001/XMLSchema#string

Kirsten C Sadler

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Raksha Mudbhary

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Shridar Ganesan

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Sucharita Senbanerjee

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P2860

ICBP90, a novel methyl K9 H3 binding protein linking protein ubiquitination with heterochromatin formation

ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain

UHRF1 plays a role in maintaining DNA methylation in mammalian cells

Critical role of the ubiquitin ligase activity of UHRF1, a nuclear RING finger protein, in tumor cell growth.

Rereplication by depletion of geminin is seen regardless of p53 status and activates a G2/M checkpoint

Np95 is a histone-binding protein endowed with ubiquitin ligase activity

ICBP90 belongs to a new family of proteins with an expression that is deregulated in cancer cells

Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro

Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation

The SRA domain of UHRF1 flips 5-methylcytosine out of the DNA helix

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175-185

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scholarly article

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10.1042/BJ20100840

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1

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435

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2011-04-01T00:00:00Z

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21214517

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3291200

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