A cell cycle-dependent BRCA1-UHRF1 cascade regulates DNA double-strand break repair pathway choice
about
Hemi-methylated DNA regulates DNA methylation inheritance through allosteric activation of H3 ubiquitylation by UHRF1The anaphase promoting complex impacts repair choice by protecting ubiquitin signalling at DNA damage sitesEpigenome Maintenance in Response to DNA DamageDNA double-strand break repair: a tale of pathway choices.Sharpening the ends for repair: mechanisms and regulation of DNA resection.Overexpression of TNKS1BP1 in lung cancers and its involvement in homologous recombination pathway of DNA double-strand breaks.Dysregulation of the BRCA1/long non-coding RNA NEAT1 signaling axis contributes to breast tumorigenesis.Mouse Rif1 is a regulatory subunit of protein phosphatase 1 (PP1).Regulatory cross-talk determines the cellular levels of 53BP1 protein, a critical factor in DNA repair.The epigenetic integrator UHRF1: on the road to become a universal biomarker for cancer.TOPBP1Dpb11 plays a conserved role in homologous recombination DNA repair through the coordinated recruitment of 53BP1Rad9.Role of UHRF1 in de novo DNA methylation in oocytes and maintenance methylation in preimplantation embryos.Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.PARP2 controls double-strand break repair pathway choice by limiting 53BP1 accumulation at DNA damage sites and promoting end-resection.Neuron-specific methylome analysis reveals epigenetic regulation and tau-related dysfunction of BRCA1 in Alzheimer's disease.Dynamics of RIF1 SUMOylation is regulated by PIAS4 in the maintenance of Genomic Stability.ATM and CDK2 control chromatin remodeler CSB to inhibit RIF1 in DSB repair pathway choice.Interaction of the epigenetic integrator UHRF1 with the MYST domain of TIP60 inside the cell.Nup153 and Nup50 promote recruitment of 53BP1 to DNA repair foci by antagonizing BRCA1-dependent events.Biochemical and structural characterization of a novel cooperative binding mode by Pit-1 with CATT repeats in the macrophage migration inhibitory factor promoter.Oligomer formation and G-quadruplex-binding by purified murine Rif1 protein, a key organizer of higher-order chromatin architecture.UHRF1 depletion sensitizes retinoblastoma cells to chemotherapeutic drugs via downregulation of XRCC4.How cells ensure correct repair of DNA double-strand breaks.Uhrf1 regulates germinal center B cell expansion and affinity maturation to control viral infection.FOXM1 contributes to taxane resistance by regulating UHRF1-controlled cancer cell stemness.Histone methylation in DNA repair and clinical practice: new findings during the past 5-years.Shepherding DNA ends: Rif1 protects telomeres and chromosome breaks.PARP inhibitor veliparib and HDAC inhibitor SAHA synergistically co-target the UHRF1/BRCA1 DNA damage repair complex in prostate cancer cellsHomology-Directed Repair and the Role of BRCA1, BRCA2, and Related Proteins in Genome Integrity and CancerChromatin structure and its chemical modifications regulate the ubiquitin ligase substrate selectivity of UHRF1
P2860
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P2860
A cell cycle-dependent BRCA1-UHRF1 cascade regulates DNA double-strand break repair pathway choice
description
2016 nî lūn-bûn
@nan
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
2016年论文
@zh
2016年论文
@zh-cn
name
A cell cycle-dependent BRCA1-U ...... nd break repair pathway choice
@ast
A cell cycle-dependent BRCA1-U ...... nd break repair pathway choice
@en
type
label
A cell cycle-dependent BRCA1-U ...... nd break repair pathway choice
@ast
A cell cycle-dependent BRCA1-U ...... nd break repair pathway choice
@en
prefLabel
A cell cycle-dependent BRCA1-U ...... nd break repair pathway choice
@ast
A cell cycle-dependent BRCA1-U ...... nd break repair pathway choice
@en
P2093
P2860
P356
P1476
A cell cycle-dependent BRCA1-U ...... nd break repair pathway choice
@en
P2093
Asha A Nair
Cristina Correia
Debra L Evans
Hailong Liu
Haoxing Zhang
Huadong Pei
Jungjin Kim
Liewei Wang
Melanie Sparks
P2860
P2888
P356
10.1038/NCOMMS10201
P407
P577
2016-01-05T00:00:00Z