mTORC1 controls fasting-induced ketogenesis and its modulation by ageing.
about
Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevityAn emerging role for TOR signaling in mammalian tissue and stem cell physiologymTOR signaling in growth control and diseaseRole of β-hydroxybutyrate, its polymer poly-β-hydroxybutyrate and inorganic polyphosphate in mammalian health and diseaseMetabolic reprogramming by class I and II histone deacetylasesMitochondrial biogenesis through activation of nuclear signaling proteinsTranscriptional repression of mitochondrial function in aging: a novel role for the silencing mediator of retinoid and thyroid hormone receptors co-repressorEnergy metabolism in the liverLow-carbohydrate ketogenic diets, glucose homeostasis, and nonalcoholic fatty liver diseaseRegulation of Ketone Body Metabolism and the Role of PPARαAkt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathwaysDepletion of Rictor, an essential protein component of mTORC2, decreases male lifespanThe TSC complex is required for the benefits of dietary protein restriction on stress resistance in vivomTOR signaling in tumorigenesisSex- and tissue-specific changes in mTOR signaling with age in C57BL/6J miceThe Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and AgingMice fed rapamycin have an increase in lifespan associated with major changes in the liver transcriptomeMacroautophagy and cell responses related to mitochondrial dysfunction, lipid metabolism and unconventional secretion of proteinsSestrin 3 protein enhances hepatic insulin sensitivity by direct activation of the mTORC2-Akt signalingSoy Isoflavones Regulate Lipid Metabolism through an AKT/mTORC1 Pathway in Diet-Induced Obesity (DIO) Male Rats.mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway.A pulse rapamycin therapy for infantile spasms and associated cognitive decline.Loss of hepatic DEPTOR alters the metabolic transition to fastingKetone Body Therapy Protects From Lipotoxicity and Acute Liver Failure Upon Pparα DeficiencyRagA, but not RagB, is essential for embryonic development and adult mice.Mitohormesis: Promoting Health and Lifespan by Increased Levels of Reactive Oxygen Species (ROS).Disruption of mammalian target of rapamycin complex 1 in macrophages decreases chemokine gene expression and atherosclerosis.mTORC1 controls the adaptive transition of quiescent stem cells from G0 to G(Alert)Transcriptional coregulators: fine-tuning metabolism.Loss of mTORC1 signalling impairs β-cell homeostasis and insulin processing.mTOR Inhibition Subdues Milk Disorder Caused by Maternal VLDLR LossTAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesisHepatic mTORC1 controls locomotor activity, body temperature, and lipid metabolism through FGF21.How wasting is saving: weight loss at altitude might result from an evolutionary adaptation.NCoR1 is a conserved physiological modulator of muscle mass and oxidative function.Ketone bodies as signaling metabolites.Identification of Akt-independent regulation of hepatic lipogenesis by mammalian target of rapamycin (mTOR) complex 2Fasting mitigates immediate hypersensitivity: a pivotal role of endogenous D-beta-hydroxybutyrate.mTORC1 signaling controls mammalian skeletal growth through stimulation of protein synthesis.Regulation of mTORC1 and its impact on gene expression at a glance.
P2860
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P2860
mTORC1 controls fasting-induced ketogenesis and its modulation by ageing.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
mTORC1 controls fasting-induced ketogenesis and its modulation by ageing.
@en
mTORC1 controls fasting-induced ketogenesis and its modulation by ageing.
@nl
type
label
mTORC1 controls fasting-induced ketogenesis and its modulation by ageing.
@en
mTORC1 controls fasting-induced ketogenesis and its modulation by ageing.
@nl
prefLabel
mTORC1 controls fasting-induced ketogenesis and its modulation by ageing.
@en
mTORC1 controls fasting-induced ketogenesis and its modulation by ageing.
@nl
P2093
P356
P1433
P1476
mTORC1 controls fasting-induced ketogenesis and its modulation by ageing
@en
P2093
Mathieu Laplante
Shomit Sengupta
Timothy R Peterson
P2888
P304
P356
10.1038/NATURE09584
P407
P577
2010-12-01T00:00:00Z
P5875
P6179
1032908836