A small-molecule inhibitor of MDMX activates p53 and induces apoptosis.
about
Clinical Overview of MDM2/X-Targeted TherapiesThe pseudoginsenoside F11 ameliorates cisplatin-induced nephrotoxicity without compromising its anti-tumor activity in vivo.Doxorubicin and 5-fluorouracil induced accumulation and transcriptional activity of p53 are independent of the phosphorylation at serine 15 in MCF-7 breast cancer cellsMDM2, MDMX and p53 in oncogenesis and cancer therapyA fluorescent-based high-throughput screening assay for small molecules that inhibit the interaction of MdmX with p53.Genome-wide characterization of pancreatic adenocarcinoma patients using next generation sequencing.Ocotillol Enhanced the Antitumor Activity of Doxorubicin via p53-Dependent ApoptosisNovel targeted therapeutics: inhibitors of MDM2, ALK and PARP.USP22 promotes NSCLC tumorigenesis via MDMX up-regulation and subsequent p53 inhibition.Blockade of Hsp90 by 17AAG antagonizes MDMX and synergizes with Nutlin to induce p53-mediated apoptosis in solid tumorsA small-molecule p53 activator induces apoptosis through inhibiting MDMX expression in breast cancer cells.Wild type p53 reactivation: from lab bench to clinic.Discovery of an NRF1-specific inducer from a large-scale chemical library using a direct NRF1-protein monitoring system.Translational approaches targeting the p53 pathway for anti-cancer therapy.XI-006 induces potent p53-independent apoptosis in Ewing sarcoma.Targeting the p53 signaling pathway in cancer therapy - the promises, challenges and perils.Targeting Mdmx to treat breast cancers with wild-type p53.Combination treatment in vitro with Nutlin, a small-molecule antagonist of MDM2, and pegylated interferon-α 2a specifically targets JAK2V617F-positive polycythemia vera cellsOn the interaction mechanisms of a p53 peptide and nutlin with the MDM2 and MDMX proteins: a Brownian dynamics study.Pharmacologic activation of p53 by small-molecule MDM2 antagonistsIdentification of a Small Molecule That Overcomes HdmX-Mediated Suppression of p53.Estrogen receptor alpha (ERα/ESR1) mediates the p53-independent overexpression of MDM4/MDMX and MDM2 in human breast cancer.Targeting ubiquitination for cancer therapies.Emerging therapies targeting the ubiquitin proteasome system in cancerThe Hsp90 inhibitor 17-(allylamino)-17-demethoxygeldanamycin increases cisplatin antitumor activity by inducing p53-mediated apoptosis in head and neck cancer.MDM2 is a potential therapeutic target and prognostic factor for ovarian clear cell carcinomas with wild type TP53.Drugging the undruggable: transcription therapy for cancer.Targeting the ubiquitin-mediated proteasome degradation of p53 for cancer therapy.Molecular pathways: targeting Mdm2 and Mdm4 in cancer therapy.Targeting p53-MDM2-MDMX loop for cancer therapy.Pharmacological reactivation of p53 as a strategy to treat cancer.Nutlin-3, A P53-Mdm2 Antagonist For Nasopharyngeal Carcinoma Treatment.XI-011 enhances cisplatin-induced apoptosis by functional restoration of p53 in head and neck cancer.Reviving the guardian of the genome: Small molecule activators of p53.MdmX is required for p53 interaction with and full induction of the Mdm2 promoter after cellular stress.Regulation of the Mdm2-p53 signaling axis in the DNA damage response and tumorigenesis.Stochastic and Deterministic Models of Cellular p53 Regulation.Antimicrobial sulfonamides clear latent Kaposi sarcoma herpesvirus infection and impair MDM2-p53 complex formation.Internal Ribosome Entry Site-Based Bicistronic In Situ Reporter Assays for Discovery of Transcription-Targeted Lead Compounds.Functional study of dextran-graft-poly((2-dimethyl amino)ethyl methacrylate) gene delivery vector for tumor therapy.
P2860
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P2860
A small-molecule inhibitor of MDMX activates p53 and induces apoptosis.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
A small-molecule inhibitor of MDMX activates p53 and induces apoptosis.
@en
A small-molecule inhibitor of MDMX activates p53 and induces apoptosis.
@nl
type
label
A small-molecule inhibitor of MDMX activates p53 and induces apoptosis.
@en
A small-molecule inhibitor of MDMX activates p53 and induces apoptosis.
@nl
prefLabel
A small-molecule inhibitor of MDMX activates p53 and induces apoptosis.
@en
A small-molecule inhibitor of MDMX activates p53 and induces apoptosis.
@nl
P2093
P2860
P1476
A small-molecule inhibitor of MDMX activates p53 and induces apoptosis.
@en
P2093
Chunhong Yan
Hongbo Wang
Shumei Ren
P2860
P356
10.1158/1535-7163.MCT-10-0581
P577
2010-11-12T00:00:00Z