Intrarenal renin angiotensin system revisited: role of megalin-dependent endocytosis along the proximal nephron. - Wikidata - awgldk - TriplyDB

Intrarenal renin angiotensin system revisited: role of megalin-dependent endocytosis along the proximal nephron.

Intrarenal renin angiotensin system revisited: role of megalin-dependent endocytosis along the proximal nephron.

http://www.wikidata.org/entity/Q39641307

about

Molecular mechanisms and regulation of urinary acidification The intrarenal generation of angiotensin II is required for experimental hypertension Nephron-specific deletion of the prorenin receptor causes a urine concentration defect.Multiphoton imaging of the glomerular permeability of angiotensinogen.Detailed localization of augmented angiotensinogen mRNA and protein in proximal tubule segments of diabetic kidneys in rats and humans.HDAC9 is an epigenetic repressor of kidney angiotensinogen establishing a sex difference Translational studies on augmentation of intratubular renin-angiotensin system in hypertension Mechanisms of AT1a receptor-mediated uptake of angiotensin II by proximal tubule cells: a novel role of the multiligand endocytic receptor megalin.Mass spectrometry for the molecular imaging of angiotensin metabolism in kidney.Overexpression of mouse angiotensinogen in renal proximal tubule causes salt-sensitive hypertension in mice Nonclassical renin-angiotensin system and renal function.Collecting duct-specific knockout of renin attenuates angiotensin II-induced hypertension.Nuclear expression of renin-angiotensin system components in NRK-52E renal epithelial cells.Intrarenal angiotensin II and its contribution to the genesis of chronic hypertension.Urinary biomarkers for early diabetic nephropathy: beyond albuminuria.ACE and ACE2 in kidney disease Unilateral ureteral obstruction attenuates intrarenal angiotensin II generation induced by podocyte injury.Increased renin excretion is associated with augmented urinary angiotensin II levels in chronic angiotensin II-infused hypertensive rats.Increased tubular proliferation as an adaptive response to glomerular albuminuria Novel roles of nuclear angiotensin receptors and signaling mechanisms.Lessons from in vitro studies and a related intracellular angiotensin II transgenic mouse model.The establishment of a primary culture system of proximal tubule segments using specific markers from normal mouse kidneys.Differential regulation of circulating and renal ACE2 and ACE in hypertensive mRen2.Lewis rats with early-onset diabetes.Liver angiotensinogen is the primary source of renal angiotensin II.Deficiency of angiotensinogen in hepatocytes markedly decreases blood pressure in lean and obese male mice Role of stimulated intrarenal angiotensinogen in hypertension.Urinary angiotensinogen as a novel early biomarker of intrarenal renin-angiotensin system activation in experimental type 1 diabetes Heterogeneous nuclear ribonucleoprotein F suppresses angiotensinogen gene expression and attenuates hypertension and kidney injury in diabetic mice.Suppressing angiotensinogen synthesis attenuates kidney cyst formation in a Pkd1 mouse model.Divergent localization of angiotensinogen mRNA and protein in proximal tubule segments of normal rat kidney Augmented intrarenal and urinary angiotensinogen in hypertension and chronic kidney disease.A local renal renin-angiotensin system activation via renal uptake of prorenin and angiotensinogen in diabetic rats.Evolving concepts on regulation and function of renin in distal nephron.Cardinal role of the intrarenal renin-angiotensin system in the pathogenesis of diabetic nephropathy.Possible role for nephron-derived angiotensinogen in angiotensin-II dependent hypertension.On the Origin of Urinary Renin: A Translational Approach.Angiotensin II blockade and renal protection.Augmentation of angiotensinogen expression in the proximal tubule by intracellular angiotensin II via AT1a/MAPK/NF-кB signaling pathways Antenatal betamethasone exposure is associated with lower ANG-(1-7) and increased ACE in the CSF of adult sheep Evidence for a functional intracellular angiotensin system in the proximal tubule of the kidney.

P2860

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P2860

Intrarenal renin angiotensin system revisited: role of megalin-dependent endocytosis along the proximal nephron.

http://www.wikidata.org/entity/Q39641307

description

2010 nî lūn-bûn

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2010年论文

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Intrarenal renin angiotensin s ...... is along the proximal nephron.

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Intrarenal renin angiotensin s ...... is along the proximal nephron.

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Franziska Theilig

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Hayo Castrop

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Henriette Kaminski

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Marcus Pohl

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Nina Himmerkus

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P2860

RAP, a specialized chaperone, prevents ligand-induced ER retention and degradation of LDL receptor-related endocytic receptors

Evidence for an essential role of megalin in transepithelial transport of retinol

Renin and angiotensinogen expression during the evolution of diabetes.

Renin expression in renal proximal tubule.

Angiotensin II stimulates trafficking of NHE3, NaPi2, and associated proteins into the proximal tubule microvilli.

Major role for ACE-independent intrarenal ANG II formation in type II diabetes.

Angiotensin II stimulates both Na(+)-H+ exchange and Na+/HCO3- cotransport in the rabbit proximal tubule.

Blood pressure control--special role of the kidneys and body fluids.

Endogenous angiotensin concentrations in specific intrarenal fluid compartments of the rat.

RAS blockade decreases blood pressure and proteinuria in transgenic mice overexpressing rat angiotensinogen gene in the kidney.

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