Activation of specific apoptotic caspases with an engineered small-molecule-activated protease.
about
Lithocholic bile acid selectively kills neuroblastoma cells, while sparing normal neuronal cellsEngineering of TEV protease variants by yeast ER sequestration screening (YESS) of combinatorial librariesStructural snapshots reveal distinct mechanisms of procaspase-3 and -7 activationA whole cell assay to measure caspase-6 activity by detecting cleavage of lamin A/CA quantitative method for the specific assessment of caspase-6 activity in cell cultureLigand-binding domains of nuclear receptors facilitate tight control of split CRISPR activityActivation of AMPK by Buddleja officinalis Maxim. Flower Extract Contributes to Protecting Hepatocytes from Oxidative Stress.Proteasome inhibition represses unfolded protein response and Nox4, sensitizing vascular cells to endoplasmic reticulum stress-induced death.Split-protein systems: beyond binary protein-protein interactionsDistinct pathways mediate axon degeneration during apoptosis and axon-specific pruningRec8-containing cohesin maintains bivalents without turnover during the growing phase of mouse oocytes.A system for the continuous directed evolution of proteases rapidly reveals drug-resistance mutationsInflammation-induced tumorigenesis in mouse colon is caspase-6 independent.Engineering the ABA plant stress pathway for regulation of induced proximity.Expression and activation of caspase-6 in human fetal and adult tissuesTurning on caspases with genetics and small moleculesAttenuation of nonsense-mediated mRNA decay facilitates the response to chemotherapeutics.Sox11 Reduces Caspase-6 Cleavage and Activity.Engineered cellular gene-replacement platform for selective and inducible proteolytic profiling.An optimized activity-based probe for the study of caspase-6 activation.Huntingtin proteolysis releases non-polyQ fragments that cause toxicity through dynamin 1 dysregulation.Fibrils colocalize caspase-3 with procaspase-3 to foster maturation.Sculpting neural circuits by axon and dendrite pruningNew approaches for dissecting protease functions to improve probe development and drug discoverySubstrates of IAP ubiquitin ligases identified with a designed orthogonal E3 ligase, the NEDDylatorp53 activation by Ni(II) is a HIF-1α independent response causing caspases 9/3-mediated apoptosis in human lung cells.XIAP downregulation promotes caspase-dependent inhibition of proteasome activity in AML cells.Phosphorylation-mediated PTEN conformational closure and deactivation revealed with protein semisynthesis.Reprogramming Caspase-7 Specificity by Regio-Specific Mutations and Selection Provides Alternate Solutions for Substrate Recognition.Sexually dimorphic neurons in the ventromedial hypothalamus govern mating in both sexes and aggression in malesCaspase-6 activity predicts lower episodic memory ability in aged individualsGlobal cellular response to chemotherapy-induced apoptosis.Rational Design of a GFP-Based Fluorogenic Caspase Reporter for Imaging Apoptosis In VivoSmall-molecule control of protein function through Staudinger reduction.Increased Caspase-6 activity in the human anterior olfactory nuclei of the olfactory bulb is associated with cognitive impairment.Post-translational control of genetic circuits using Potyvirus proteases.Interactome disassembly during apoptosis occurs independent of caspase cleavage.Genetic variations in apoptosis pathway and the risk of ovarian cancer.Caspase-6 activity in the CA1 region of the hippocampus induces age-dependent memory impairment.Engineering protein switches: sensors, regulators, and spare parts for biology and biotechnology.
P2860
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P2860
Activation of specific apoptotic caspases with an engineered small-molecule-activated protease.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
Activation of specific apoptot ...... l-molecule-activated protease.
@en
Activation of specific apoptot ...... l-molecule-activated protease.
@nl
type
label
Activation of specific apoptot ...... l-molecule-activated protease.
@en
Activation of specific apoptot ...... l-molecule-activated protease.
@nl
prefLabel
Activation of specific apoptot ...... l-molecule-activated protease.
@en
Activation of specific apoptot ...... l-molecule-activated protease.
@nl
P2093
P2860
P1433
P1476
Activation of specific apoptot ...... l-molecule-activated protease.
@en
P2093
Daniel C Gray
James A Wells
Sami Mahrus
P2860
P304
P356
10.1016/J.CELL.2010.07.014
P407
P577
2010-08-01T00:00:00Z