The TSC1 and TSC2 tumor suppressors are required for proper ER stress response and protect cells from ER stress-induced apoptosis.
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Caloric restriction: is mammalian life extension linked to p53?Non-canonical functions of the tuberous sclerosis complex-Rheb signalling axisGenomic profile analysis of diffuse-type gastric cancersER stress induces anabolic resistance in muscle cells through PKB-induced blockade of mTORC1.Hepatic mTORC1 controls locomotor activity, body temperature, and lipid metabolism through FGF21.Synthetic lethality of combined glutaminase and Hsp90 inhibition in mTORC1-driven tumor cellsLoss of the tuberous sclerosis complex protein tuberin causes Purkinje cell degenerationAkt inhibition promotes ABCA1-mediated cholesterol efflux to ApoA-I through suppressing mTORC1.An mTORC1-Mdm2-Drosha axis for miRNA biogenesis in response to glucose- and amino acid-deprivation.Pan-Bcl-2 inhibitor Obatoclax is a potent late stage autophagy inhibitor in colorectal cancer cells independent of canonical autophagy signaling.mTOR inhibitors induce apoptosis in colon cancer cells via CHOP-dependent DR5 induction on 4E-BP1 dephosphorylation.Human TSC-associated renal angiomyolipoma cells are hypersensitive to ER stress.IKK-β mediates hydrogen peroxide induced cell death through p85 S6K1mTORC1 and CK2 coordinate ternary and eIF4F complex assembly.ER stress: Autophagy induction, inhibition and selection.Eukaryotic initiation factor 2 phosphorylation and translational control in metabolism.Dysregulated mTORC1 renders cells critically dependent on desaturated lipids for survival under tumor-like stress.Ras and rheb signaling in survival and cell deathRegulation of PERK-eIF2α signalling by tuberous sclerosis complex-1 controls homoeostasis and survival of myelinating oligodendrocytesFatty acid extract from CLA-enriched egg yolks can mediate transcriptome reprogramming of MCF-7 cancer cells to prevent their growth and proliferationLoss of TSC2 confers resistance to ceramide and nutrient deprivation.Targeting tissue-specific metabolic signaling pathways in aging: the promise and limitations.mTOR complex 1 signalling regulates the balance between lipid synthesis and oxidation in hypoxia lymphocytesBAP1 inhibits the ER stress gene regulatory network and modulates metabolic stress response.The tuberous sclerosis complex: balancing proliferation and survival.Control of oncogenesis by eIF2α phosphorylation: implications in PTEN and PI3K-Akt signaling and tumor treatment.Endoplasmic reticulum stress in human skeletal muscle: any contribution to sarcopenia?Role of AMP-activated protein kinase in cancer therapy.Transcriptional regulation of the stress response by mTOR.Rheb Inhibits Protein Synthesis by Activating the PERK-eIF2α Signaling CascadeRheb signaling and tumorigenesis: mTORC1 and new horizons.mTOR inhibitors activate PERK signaling and favor viability of gastrointestinal neuroendocrine cell lines.Molecular mechanisms of mTOR regulation by stressEndoplasmic reticulum stress and cell death in mTORC1-overactive cells is induced by nelfinavir and enhanced by chloroquine.3-substituted indazoles as configurationally locked 4EGI-1 mimetics and inhibitors of the eIF4E/eIF4G interaction.Activated ERBB2/HER2 licenses sensitivity to apoptosis upon endoplasmic reticulum stress through a PERK-dependent pathway.Mammalian target of rapamycin complex 1 (mTORC1) enhances bortezomib-induced death in tuberous sclerosis complex (TSC)-null cells by a c-MYC-dependent induction of the unfolded protein response.mTORC1 senses stresses: Coupling stress to proteostasis.Autophagy plays a protective role in endoplasmic reticulum stress-mediated pancreatic β cell death.Consequences of interrupted Rheb-to-AMPK feedback signaling in tuberous sclerosis complex and cancer.
P2860
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P2860
The TSC1 and TSC2 tumor suppressors are required for proper ER stress response and protect cells from ER stress-induced apoptosis.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
The TSC1 and TSC2 tumor suppre ...... m ER stress-induced apoptosis.
@en
The TSC1 and TSC2 tumor suppre ...... m ER stress-induced apoptosis.
@nl
type
label
The TSC1 and TSC2 tumor suppre ...... m ER stress-induced apoptosis.
@en
The TSC1 and TSC2 tumor suppre ...... m ER stress-induced apoptosis.
@nl
prefLabel
The TSC1 and TSC2 tumor suppre ...... m ER stress-induced apoptosis.
@en
The TSC1 and TSC2 tumor suppre ...... m ER stress-induced apoptosis.
@nl
P2093
P2860
P356
P1476
The TSC1 and TSC2 tumor suppre ...... m ER stress-induced apoptosis.
@en
P2093
P2860
P2888
P304
P356
10.1038/CDD.2010.82
P577
2010-07-09T00:00:00Z