Human cytomegalovirus UL84 localizes to the cell nucleus via a nuclear localization signal and is a component of viral replication compartments.
about
A nonconventional nuclear localization signal within the UL84 protein of human cytomegalovirus mediates nuclear import via the importin alpha/beta pathwayInhibition of human cytomegalovirus replication via peptide aptamers directed against the nonconventional nuclear localization signal of the essential viral replication factor pUL84.Infection-dependent nuclear localization of US17, a member of the US12 family of human cytomegalovirus-encoded seven-transmembrane proteins.The human cytomegalovirus DNA polymerase processivity factor UL44 is modified by SUMO in a DNA-dependent manner.The IE2 60-kilodalton and 40-kilodalton proteins are dispensable for human cytomegalovirus replication but are required for efficient delayed early and late gene expression and production of infectious virus.Human cytomegalovirus UL84 interacts with an RNA stem-loop sequence found within the RNA/DNA hybrid region of oriLyt.Human cytomegalovirus UL76 encodes a novel virion-associated protein that is able to inhibit viral replication.Dynamic and nucleolin-dependent localization of human cytomegalovirus UL84 to the periphery of viral replication compartments and nucleoli.Guinea pig cytomegalovirus GP84 is a functional homolog of the human cytomegalovirus (HCMV) UL84 gene that can complement for the loss of UL84 in a chimeric HCMV.Nucleocytoplasmic shuttling of human cytomegalovirus UL84 is essential for virus growth.Human cytomegalovirus UL84 oligomerization and heterodimerization domains act as transdominant inhibitors of oriLyt-dependent DNA replication: evidence that IE2-UL84 and UL84-UL84 interactions are required for lytic DNA replicationInteraction of HCMV UL84 with C/EBPalpha transcription factor binding sites within oriLyt is essential for lytic DNA replication.Human cytomegalovirus UL84 insertion mutant defective for viral DNA synthesis and growth.Human cytomegalovirus DNA replication requires transcriptional activation via an IE2- and UL84-responsive bidirectional promoter element within oriLyt.New genes from old: redeployment of dUTPase by herpesviruses.
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P2860
Human cytomegalovirus UL84 localizes to the cell nucleus via a nuclear localization signal and is a component of viral replication compartments.
description
2002 nî lūn-bûn
@nan
2002年の論文
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2002年論文
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2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
2002年论文
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2002年论文
@zh-cn
name
Human cytomegalovirus UL84 loc ...... iral replication compartments.
@en
Human cytomegalovirus UL84 loc ...... iral replication compartments.
@nl
type
label
Human cytomegalovirus UL84 loc ...... iral replication compartments.
@en
Human cytomegalovirus UL84 loc ...... iral replication compartments.
@nl
prefLabel
Human cytomegalovirus UL84 loc ...... iral replication compartments.
@en
Human cytomegalovirus UL84 loc ...... iral replication compartments.
@nl
P2860
P1433
P1476
Human cytomegalovirus UL84 loc ...... iral replication compartments.
@en
P2093
Kelly S Colletti
P2860
P304
P356
10.1128/JVI.76.17.8931-8938.2002
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P577
2002-09-01T00:00:00Z