Human cytomegalovirus UL84 insertion mutant defective for viral DNA synthesis and growth.
about
Inhibition of human cytomegalovirus replication via peptide aptamers directed against the nonconventional nuclear localization signal of the essential viral replication factor pUL84.Identification of human cytomegalovirus UL84 virus- and cell-encoded binding partners by using proteomics analysisRole of the specific interaction of UL112-113 p84 with UL44 DNA polymerase processivity factor in promoting DNA replication of human cytomegalovirus.The carboxy-terminal segment of the human cytomegalovirus DNA polymerase accessory subunit UL44 is crucial for viral replication.Inhibition of cellular DNA synthesis by the human cytomegalovirus IE86 protein is necessary for efficient virus replication.The IE2 60-kilodalton and 40-kilodalton proteins are dispensable for human cytomegalovirus replication but are required for efficient delayed early and late gene expression and production of infectious virus.Human cytomegalovirus UL84 interacts with an RNA stem-loop sequence found within the RNA/DNA hybrid region of oriLyt.Dynamic and nucleolin-dependent localization of human cytomegalovirus UL84 to the periphery of viral replication compartments and nucleoli.Differential Requirement of Human Cytomegalovirus UL112-113 Protein Isoforms for Viral Replication.Human cytomegalovirus UL84 protein contains two nuclear export signals and shuttles between the nucleus and the cytoplasmDown-regulation of human cytomegalovirus UL138, a novel latency-associated determinant, by hcmv-miR-UL36.A mutation deleting sequences encoding the amino terminus of human cytomegalovirus UL84 impairs interaction with UL44 and capsid localizationGuinea pig cytomegalovirus GP84 is a functional homolog of the human cytomegalovirus (HCMV) UL84 gene that can complement for the loss of UL84 in a chimeric HCMV.Nucleocytoplasmic shuttling of human cytomegalovirus UL84 is essential for virus growth.Interaction of HCMV UL84 with C/EBPalpha transcription factor binding sites within oriLyt is essential for lytic DNA replication.Analysis of the association of the human cytomegalovirus DNA polymerase subunit UL44 with the viral DNA replication factor UL84.Internal deletions of IE2 86 and loss of the late IE2 60 and IE2 40 proteins encoded by human cytomegalovirus affect the levels of UL84 protein but not the amount of UL84 mRNA or the loading and distribution of the mRNA on polysomesNew genes from old: redeployment of dUTPase by herpesviruses.A novel DDB2-ATM feedback loop regulates human cytomegalovirus replication.
P2860
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P2860
Human cytomegalovirus UL84 insertion mutant defective for viral DNA synthesis and growth.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
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2004年學術文章
@zh-hant
name
Human cytomegalovirus UL84 insertion mutant defective for viral DNA synthesis and growth.
@en
Human cytomegalovirus UL84 insertion mutant defective for viral DNA synthesis and growth.
@nl
type
label
Human cytomegalovirus UL84 insertion mutant defective for viral DNA synthesis and growth.
@en
Human cytomegalovirus UL84 insertion mutant defective for viral DNA synthesis and growth.
@nl
prefLabel
Human cytomegalovirus UL84 insertion mutant defective for viral DNA synthesis and growth.
@en
Human cytomegalovirus UL84 insertion mutant defective for viral DNA synthesis and growth.
@nl
P2093
P2860
P1433
P1476
Human cytomegalovirus UL84 insertion mutant defective for viral DNA synthesis and growth.
@en
P2093
Alicia Rodriguez Huete
Sylvia A Cei
P2860
P304
10360-10369
P356
10.1128/JVI.78.19.10360-10369.2004
P407
P577
2004-10-01T00:00:00Z