Discovery of CX-6258. A Potent, Selective, and Orally Efficacious pan-Pim Kinases Inhibitor.
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Structure Guided Optimization, in Vitro Activity, and in Vivo Activity of Pan-PIM Kinase InhibitorsCharacterization of HJ-PI01 as a novel Pim-2 inhibitor that induces apoptosis and autophagic cell death in triple-negative human breast cancerComputational prediction and experimental validation of a novel synthesized pan-PIM inhibitor PI003 and its apoptosis-inducing mechanisms in cervical cancer.Synthesis of 3-(3-aryl-pyrrolidin-1-yl)-5-aryl-1,2,4-triazines that have antibacterial activity and also inhibit inorganic pyrophosphatase.Inhibition of oncogenic Pim-3 kinase modulates transformed growth and chemosensitizes pancreatic cancer cells to gemcitabine.Protein profiling identifies mTOR pathway modulation and cytostatic effects of Pim kinase inhibitor, AZD1208, in acute myeloid leukemia.Structural analysis of PIM1 kinase complexes with ATP-competitive inhibitors.Unique anti-myeloma activity by thiazolidine-2,4-dione compounds with Pim inhibiting activity.An efficient continuous flow approach to furnish furan-based biaryls
P2860
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P2860
Discovery of CX-6258. A Potent, Selective, and Orally Efficacious pan-Pim Kinases Inhibitor.
description
2011 nî lūn-bûn
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2011年の論文
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2011年学术文章
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2011年学术文章
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2011年学术文章
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2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
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2011年學術文章
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2011年學術文章
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name
Discovery of CX-6258. A Potent ...... ous pan-Pim Kinases Inhibitor.
@en
Discovery of CX-6258. A Potent ...... ous pan-Pim Kinases Inhibitor.
@nl
type
label
Discovery of CX-6258. A Potent ...... ous pan-Pim Kinases Inhibitor.
@en
Discovery of CX-6258. A Potent ...... ous pan-Pim Kinases Inhibitor.
@nl
prefLabel
Discovery of CX-6258. A Potent ...... ous pan-Pim Kinases Inhibitor.
@en
Discovery of CX-6258. A Potent ...... ous pan-Pim Kinases Inhibitor.
@nl
P2093
P2860
P356
P1476
Discovery of CX-6258. A Potent ...... ous pan-Pim Kinases Inhibitor.
@en
P2093
Adam Siddiqui-Jain
Chris Proffitt
Cosmin Borsan
David M Ryckman
Denis Drygin
Diwata Macalino
Fabrice Pierre
Jeffrey P Whitten
Jerome Michaux
P2860
P304
P356
10.1021/ML200259Q
P577
2011-12-27T00:00:00Z