Characterization of a potent and selective small-molecule inhibitor of the PIM1 kinase
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PIM serine/threonine kinases in the pathogenesis and therapy of hematologic malignancies and solid cancersMechanism of inhibition of bovine F1-ATPase by resveratrol and related polyphenolsCell-permeable Carboxyl-terminal p27Kip1 Peptide Exhibits Anti-tumor Activity by Inhibiting Pim-1 KinaseFlexibility of the P-loop of Pim-1 kinase: observation of a novel conformation induced by interaction with an inhibitorStructural and functional analysis of the natural JNK1 inhibitor quercetagetinIdentification of quercitrin as an inhibitor of the p90 S6 ribosomal kinase (RSK): structure of its complex with the N-terminal domain of RSK2 at 1.8 Å resolutionCrystal Structure of Pim1 Kinase in Complex with a Pyrido[4,3-D]Pyrimidine Derivative Suggests a Unique Binding ModeA small-molecule inhibitor of PIM kinases as a potential treatment for urothelial carcinomasTargeting Pim kinases for cancer treatment: opportunities and challengesThe PIM kinases in hematological cancersPIM1 kinase as a target for cancer therapyPim-1 controls NF-kappaB signalling by stabilizing RelA/p65Pim kinase inhibitors: a survey of the patent literatureSmall molecule inhibitors of PIM1 kinase: July 2009 to February 2013 patent updatePrediction of molecular targets of cancer preventing flavonoid compounds using computational methodsFlavonoids as CDK1 Inhibitors: Insights in Their Binding Orientations and Structure-Activity RelationshipPim-selective inhibitor DHPCC-9 reveals Pim kinases as potent stimulators of cancer cell migration and invasionRHAMM (CD168) is overexpressed at the protein level and may constitute an immunogenic antigen in advanced prostate cancer disease.Ki67 and PIM1 expression predict outcome in mantle cell lymphoma treated with high dose therapy, stem cell transplantation and rituximab: a Cancer and Leukemia Group B 59909 correlative science studyPharmacologic inhibition of Pim kinases alters prostate cancer cell growth and resensitizes chemoresistant cells to taxanes.Synthesis and evaluation of novel inhibitors of Pim-1 and Pim-2 protein kinases.Androgen deprivation therapy has no effect on Pim-1 expression in a mouse model of prostate cancer.Pathophysiological roles of Pim-3 kinase in pancreatic cancer development and progression.Pim-1 knockdown potentiates paclitaxel-induced apoptosis in human hormone-refractory prostate cancers through inhibition of NHEJ DNA repair.Cross-talk between amino acid residues and flavonoid derivatives: insights into their chemical recognition.Pim1 kinase is upregulated in glioblastoma multiforme and mediates tumor cell survival.Pim-1 kinase phosphorylates and stabilizes 130 kDa FLT3 and promotes aberrant STAT5 signaling in acute myeloid leukemia with FLT3 internal tandem duplicationDiscovery of small molecule inhibitors of xyloglucan endotransglucosylase (XET) activity by high-throughput screening.PIM1 regulates glycolysis and promotes tumor progression in hepatocellular carcinomaCharacterization of flavonol inhibition of DnaB helicase: real-time monitoring, structural modeling, and proposed mechanism.Insights into dietary flavonoids as molecular templates for the design of anti-platelet drugsInhibition of LRRK2 kinase activity leads to dephosphorylation of Ser(910)/Ser(935), disruption of 14-3-3 binding and altered cytoplasmic localizationIdentification of quinones as novel PIM1 kinase inhibitorsPIM-1-specific mAb suppresses human and mouse tumor growth by decreasing PIM-1 levels, reducing Akt phosphorylation, and activating apoptosis.Pim-1 kinase expression predicts radiation response in squamocellular carcinoma of head and neck and is under the control of epidermal growth factor receptor.Why target PIM1 for cancer diagnosis and treatment?Plant polyphenols: chemical properties, biological activities, and synthesis.Roles of Pim-3, a novel survival kinase, in tumorigenesis.Similar interactions of natural products with biosynthetic enzymes and therapeutic targets could explain why nature produces such a large proportion of existing drugs.Natural products as kinase inhibitors.
P2860
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P2860
Characterization of a potent and selective small-molecule inhibitor of the PIM1 kinase
description
2007 nî lūn-bûn
@nan
2007 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
name
Characterization of a potent and selective small-molecule inhibitor of the PIM1 kinase
@ast
Characterization of a potent and selective small-molecule inhibitor of the PIM1 kinase
@en
Characterization of a potent and selective small-molecule inhibitor of the PIM1 kinase
@nl
type
label
Characterization of a potent and selective small-molecule inhibitor of the PIM1 kinase
@ast
Characterization of a potent and selective small-molecule inhibitor of the PIM1 kinase
@en
Characterization of a potent and selective small-molecule inhibitor of the PIM1 kinase
@nl
prefLabel
Characterization of a potent and selective small-molecule inhibitor of the PIM1 kinase
@ast
Characterization of a potent and selective small-molecule inhibitor of the PIM1 kinase
@en
Characterization of a potent and selective small-molecule inhibitor of the PIM1 kinase
@nl
P2093
P3181
P1476
Characterization of a potent and selective small-molecule inhibitor of the PIM1 kinase
@en
P2093
Jonathan W Neidigh
Marina Zemskova
Maryam Tabrizizad
Michael B Lilly
Ryan Bremer
Sheldon Holder
P304
P3181
P356
10.1158/1535-7163.MCT-06-0397
P50
P577
2007-01-01T00:00:00Z