A point mutation in the 14alpha-sterol demethylase gene cyp51A contributes to itraconazole resistance in Aspergillus fumigatus.
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Emerging Threats in Antifungal-Resistant Fungal PathogensStructural Characterization of CYP51 from Trypanosoma cruzi and Trypanosoma brucei Bound to the Antifungal Drugs Posaconazole and FluconazoleEssential gene identification and drug target prioritization in Aspergillus fumigatusDiscovery of a HapE mutation that causes azole resistance in Aspergillus fumigatus through whole genome sequencing and sexual crossingAntifungal Therapy: New Advances in the Understanding and Treatment of MycosisPredicting Resistance by Mutagenesis: Lessons from 45 Years of MBC ResistanceTriazole Resistance in Aspergillus Species: An Emerging Problem.Clinical implications of globally emerging azole resistance in Aspergillus fumigatus.SUN proteins belong to a novel family of β-(1,3)-glucan-modifying enzymes involved in fungal morphogenesisDevelopment of azole resistance in Aspergillus fumigatus during azole therapy associated with change in virulence.In Vitro and In Vivo Antifungal Profile of a Novel and Long-Acting Inhaled Azole, PC945, on Aspergillus fumigatus Infection.Genetic dissection of azole resistance mechanisms in Candida albicans and their validation in a mouse model of disseminated infectionDifferences in interactions between azole drugs related to modifications in the 14-alpha sterol demethylase gene (cyp51A) of Aspergillus fumigatus.Targeted gene disruption of the 14-alpha sterol demethylase (cyp51A) in Aspergillus fumigatus and its role in azole drug susceptibility.A Novel Environmental Azole Resistance Mutation in Aspergillus fumigatus and a Possible Role of Sexual Reproduction in Its Emergence.Combined activity in vitro of caspofungin, amphotericin B, and azole agents against itraconazole-resistant clinical isolates of Aspergillus fumigatus.A nonazole CYP51 inhibitor cures Chagas' disease in a mouse model of acute infection.Regulatory circuitry governing fungal development, drug resistance, and disease.Resistance to antifungals that target CYP51.Complementation of a Saccharomyces cerevisiae ERG11/CYP51 (sterol 14α-demethylase) doxycycline-regulated mutant and screening of the azole sensitivity of Aspergillus fumigatus isoenzymes CYP51A and CYP51B.Aspergillus fumigatus C-5 sterol desaturases Erg3A and Erg3B: role in sterol biosynthesis and antifungal drug susceptibility.Elucidating drug resistance in human fungal pathogens.Identification of novel genes conferring altered azole susceptibility in Aspergillus fumigatus.Isavuconazole: A New Option for the Management of Invasive Fungal Infections.Practice Guidelines for the Diagnosis and Management of Aspergillosis: 2016 Update by the Infectious Diseases Society of America.Drug strategies targeting CYP51 in neglected tropical diseasesAspergillus fumigatus strains with mutations in the cyp51A gene do not always show phenotypic resistance to itraconazole, voriconazole, or posaconazole.Substitutions at methionine 220 in the 14alpha-sterol demethylase (Cyp51A) of Aspergillus fumigatus are responsible for resistance in vitro to azole antifungal drugs.Prevalence and mechanism of triazole resistance in Aspergillus fumigatus in a referral chest hospital in Delhi, India and an update of the situation in AsiaAntifungal susceptibilities of Aspergillus fumigatus clinical isolates obtained in Nagasaki, JapanRapid induction of multiple resistance mechanisms in Aspergillus fumigatus during azole therapy: a case study and review of the literature.Triazole Susceptibilities in Thermotolerant Fungal Isolates from Outdoor Air in the Seoul Capital Area in South Korea.In Vitro Biochemical Study of CYP51-Mediated Azole Resistance in Aspergillus fumigatusIdentification of a Cryptococcus neoformans cytochrome P450 lanosterol 14α-demethylase (Erg11) residue critical for differential susceptibility between fluconazole/voriconazole and itraconazole/posaconazole.Clinical implications of azole resistance in Aspergillus fumigatus, The Netherlands, 2007-2009.Resistance to voriconazole due to a G448S substitution in Aspergillus fumigatus in a patient with cerebral aspergillosis.Time of incubation for antifungal susceptibility testing of Aspergillus fumigatus: can MIC values be obtained at 24 hours?Rapid detection of triazole antifungal resistance in Aspergillus fumigatus.Molecular Characterization of a Voriconazole-Resistant, Posaconazole-Susceptible Aspergillus fumigatus Isolate in a Lung Transplant Recipient in the United States.Is azole resistance in Aspergillus fumigatus a problem in Spain?
P2860
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P2860
A point mutation in the 14alpha-sterol demethylase gene cyp51A contributes to itraconazole resistance in Aspergillus fumigatus.
description
2003 nî lūn-bûn
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2003年の論文
@ja
2003年学术文章
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2003年学术文章
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2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
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name
A point mutation in the 14alph ...... ance in Aspergillus fumigatus.
@en
A point mutation in the 14alph ...... ance in Aspergillus fumigatus.
@nl
type
label
A point mutation in the 14alph ...... ance in Aspergillus fumigatus.
@en
A point mutation in the 14alph ...... ance in Aspergillus fumigatus.
@nl
prefLabel
A point mutation in the 14alph ...... ance in Aspergillus fumigatus.
@en
A point mutation in the 14alph ...... ance in Aspergillus fumigatus.
@nl
P2093
P2860
P921
P1476
A point mutation in the 14alph ...... ance in Aspergillus fumigatus.
@en
P2093
Cuenca-Estrella M
Diaz-Guerra TM
Rodriguez-Tudela JL
P2860
P304
P356
10.1128/AAC.47.3.1120-1124.2003
P407
P577
2003-03-01T00:00:00Z