A nonazole CYP51 inhibitor cures Chagas' disease in a mouse model of acute infection.
about
Organocatalytic, enantioselective synthesis of VNI: a robust therapeutic development platform for Chagas, a neglected tropical diseaseReverse type I inhibitor of Mycobacterium tuberculosis CYP125A1Rational Development of 4-Aminopyridyl-Based Inhibitors Targeting Trypanosoma cruzi CYP51 as Anti-Chagas AgentsExpanding the Binding Envelope of CYP51 Inhibitors TargetingTrypanosoma cruziwith 4-Aminopyridyl-Based Sulfonamide Derivatives4-Aminopyridyl-Based CYP51 Inhibitors as Anti- Trypanosoma cruzi Drug Leads with Improved Pharmacokinetic Profile and in Vivo PotencyDiverse inhibitor chemotypes targeting Trypanosoma cruzi CYP51Automated high-content assay for compounds selectively toxic to Trypanosoma cruzi in a myoblastic cell lineTargeting Ergosterol biosynthesis in Leishmania donovani: essentiality of sterol 14 alpha-demethylaseNew compound sets identified from high throughput phenotypic screening against three kinetoplastid parasites: an open resource.Image-based high-throughput drug screening targeting the intracellular stage of Trypanosoma cruzi, the agent of Chagas' disease.Novel carboline derivatives as potent antifungal lead compounds: design, synthesis, and biological evaluation.Resistance to antifungals that target CYP51.Drug strategies targeting CYP51 in neglected tropical diseasesBinding mode and potency of N-indolyloxopyridinyl-4-aminopropanyl-based inhibitors targeting Trypanosoma cruzi CYP51.Drug discovery for neglected tropical diseases at the Sandler Center.Interactions of antiparasitic sterols with sterol 14α-demethylase (CYP51) of human pathogensThe Effectiveness of Natural Diarylheptanoids against Trypanosoma cruzi: Cytotoxicity, Ultrastructural Alterations and Molecular Modeling StudiesTargeting Trypanosoma cruzi sterol 14α-demethylase (CYP51)Cathepsin Inhibition Prevents Autophagic Protein Turnover and Downregulates Insulin Growth Factor-1 Receptor-Mediated Signaling in NeuroblastomaChemical-biological characterization of a cruzain inhibitor reveals a second target and a mammalian off-target.Azole affinity of sterol 14α-demethylase (CYP51) enzymes from Candida albicans and Homo sapiens.Advances in Chagas disease drug development: 2009-2010Two analogues of fenarimol show curative activity in an experimental model of Chagas disease.Therapeutical approaches under investigation for treatment of Chagas disease.Cholesterol metabolism: a potential therapeutic target in Mycobacteria.Chemogenetic Characterization of Inositol Phosphate Metabolic Pathway Reveals Druggable Enzymes for Targeting Kinetoplastid Parasites.Hydroxamic acid derivatives: a promising scaffold for rational compound optimization in Chagas disease.Recent Developments in Sterol 14-demethylase Inhibitors for Chagas Disease.Pharmacokinetics of hydroxymethylnitrofurazone, a promising new prodrug for Chagas' disease treatmentCYP51 is an essential drug target for the treatment of primary amoebic meningoencephalitis (PAM).4-aminopyridyl-based lead compounds targeting CYP51 prevent spontaneous parasite relapse in a chronic model and improve cardiac pathology in an acute model of Trypanosoma cruzi infection.Structural design, synthesis and structure-activity relationships of thiazolidinones with enhanced anti-Trypanosoma cruzi activity.Rational Selection of Anti-Microbial Drug Targets: Unique or Conserved?
P2860
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P2860
A nonazole CYP51 inhibitor cures Chagas' disease in a mouse model of acute infection.
description
2010 nî lūn-bûn
@nan
2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
A nonazole CYP51 inhibitor cures Chagas' disease in a mouse model of acute infection.
@ast
A nonazole CYP51 inhibitor cures Chagas' disease in a mouse model of acute infection.
@en
type
label
A nonazole CYP51 inhibitor cures Chagas' disease in a mouse model of acute infection.
@ast
A nonazole CYP51 inhibitor cures Chagas' disease in a mouse model of acute infection.
@en
prefLabel
A nonazole CYP51 inhibitor cures Chagas' disease in a mouse model of acute infection.
@ast
A nonazole CYP51 inhibitor cures Chagas' disease in a mouse model of acute infection.
@en
P2093
P2860
P356
P1476
A nonazole CYP51 inhibitor cures Chagas' disease in a mouse model of acute infection.
@en
P2093
Chiung-Kuang Chen
Jonathan B Johnston
Juan C Engel
Larissa M Podust
Patricia S Doyle
Siegfried S F Leung
Stephanie D Hopkins
P2860
P304
P356
10.1128/AAC.00281-10
P407
P577
2010-04-12T00:00:00Z