Glycoprotein I of varicella-zoster virus is required for viral replication in skin and T cells.
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Dissecting the Molecular Mechanisms of the Tropism of Varicella-Zoster Virus for Human T CellsGenome-wide mutagenesis reveals that ORF7 is a novel VZV skin-tropic factorDysregulated Glycoprotein B-Mediated Cell-Cell Fusion Disrupts Varicella-Zoster Virus and Host Gene Transcription during Infection.The insulin degrading enzyme binding domain of varicella-zoster virus (VZV) glycoprotein E is important for cell-to-cell spread and VZV infectivity, while a glycoprotein I binding domain is essential for infection.Functions of the unique N-terminal region of glycoprotein E in the pathogenesis of varicella-zoster virus infectionRole of the varicella-zoster virus gene product encoded by open reading frame 35 in viral replication in vitro and in differentiated human skin and T cells in vivo.Molecular mechanisms of varicella zoster virus pathogenesis.Varicella-Zoster virus pathogenesis and immunobiology: new concepts emerging from investigations with the SCIDhu mouse model.Comparison of virus transcription during lytic infection of the Oka parental and vaccine strains of Varicella-Zoster virusVaricella-zoster virus glycoprotein E is a critical determinant of virulence in the SCID mouse-human model of neuropathogenesisVaricella-zoster virus open reading frame 10 is a virulence determinant in skin cells but not in T cells in vivoInhibition of the NF-kappaB pathway by varicella-zoster virus in vitro and in human epidermal cells in vivo.Mutational analysis of open reading frames 62 and 71, encoding the varicella-zoster virus immediate-early transactivating protein, IE62, and effects on replication in vitro and in skin xenografts in the SCID-hu mouse in vivo.Mutagenesis of varicella-zoster virus glycoprotein I (gI) identifies a cysteine residue critical for gE/gI heterodimer formation, gI structure, and virulence in skin cells.Essential functions of the unique N-terminal region of the varicella-zoster virus glycoprotein E ectodomain in viral replication and in the pathogenesis of skin infectionThe ubiquitous cellular transcriptional factor USF targets the varicella-zoster virus open reading frame 10 promoter and determines virulence in human skin xenografts in SCIDhu mice in vivo.The amino terminus of varicella-zoster virus (VZV) glycoprotein E is required for binding to insulin-degrading enzyme, a VZV receptor.Aberrant infection and persistence of varicella-zoster virus in human dorsal root ganglia in vivo in the absence of glycoprotein I.Rodent models of varicella-zoster virus neurotropism.Varicella-zoster virus ORF47 protein kinase, which is required for replication in human T cells, and ORF66 protein kinase, which is expressed during latency, are dispensable for establishment of latency.Deletion of the first cysteine-rich region of the varicella-zoster virus glycoprotein E ectodomain abolishes the gE and gI interaction and differentially affects cell-cell spread and viral entry.Global Mapping of O-Glycosylation of Varicella Zoster Virus, Human Cytomegalovirus, and Epstein-Barr Virus.Enhanced Viral Replication by Cellular Replicative Senescence.Differential requirement for cell fusion and virion formation in the pathogenesis of varicella-zoster virus infection in skin and T cells.Functions of the C-terminal domain of varicella-zoster virus glycoprotein E in viral replication in vitro and skin and T-cell tropism in vivo.Molecular studies of the Oka varicella vaccine.Varicella-Zoster Virus Glycoproteins: Entry, Replication, and Pathogenesis.Promoter sequences of varicella-zoster virus glycoprotein I targeted by cellular transactivating factors Sp1 and USF determine virulence in skin and T cells in SCIDhu mice in vivo.Mutagenesis of varicella-zoster virus glycoprotein B: putative fusion loop residues are essential for viral replication, and the furin cleavage motif contributes to pathogenesis in skin tissue in vivo.Roscovitine, a cyclin-dependent kinase inhibitor, prevents replication of varicella-zoster virus.Varicella-zoster virus open reading frame 66 protein kinase is required for efficient viral growth in primary human corneal stromal fibroblast cells.Replication of varicella-zoster virus in human skin organ culture
P2860
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P2860
Glycoprotein I of varicella-zoster virus is required for viral replication in skin and T cells.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh
2002年學術文章
@zh-hant
name
Glycoprotein I of varicella-zo ...... plication in skin and T cells.
@en
Glycoprotein I of varicella-zo ...... plication in skin and T cells.
@nl
type
label
Glycoprotein I of varicella-zo ...... plication in skin and T cells.
@en
Glycoprotein I of varicella-zo ...... plication in skin and T cells.
@nl
prefLabel
Glycoprotein I of varicella-zo ...... plication in skin and T cells.
@en
Glycoprotein I of varicella-zo ...... plication in skin and T cells.
@nl
P2093
P2860
P1433
P1476
Glycoprotein I of varicella-zo ...... plication in skin and T cells.
@en
P2093
Ann M Arvin
Hideki Ito
Jennifer Moffat
Marvin Sommer
Shannon Taylor
P2860
P304
P356
10.1128/JVI.76.16.8468-8471.2002
P407
P577
2002-08-01T00:00:00Z