Characterization of a high-activity mutant of human butyrylcholinesterase against (-)-cocaine.
about
Long-acting cocaine hydrolase for addiction therapyModeling of pharmacokinetics of cocaine in human reveals the feasibility for development of enzyme therapies for drugs of abuseGene transfer of mutant mouse cholinesterase provides high lifetime expression and reduced cocaine responses with no evident toxicityDesign of high-activity mutants of human butyrylcholinesterase against (-)-cocaine: structural and energetic factors affecting the catalytic efficiency.Physiologic and metabolic safety of butyrylcholinesterase gene therapy in miceAccelerating cocaine metabolism as an approach to the treatment of cocaine abuse and toxicityCombined cocaine hydrolase gene transfer and anti-cocaine vaccine synergistically block cocaine-induced locomotion.Design, preparation, and characterization of high-activity mutants of human butyrylcholinesterase specific for detoxification of cocaine.Preparation and in vivo characterization of a cocaine hydrolase engineered from human butyrylcholinesterase for metabolizing cocaine.Enzyme-therapy approaches for the treatment of drug overdose and addiction.His-tag truncated butyrylcholinesterase as a useful construct for in vitro characterization of wild-type and variant butyrylcholinesterases.Plant expression of cocaine hydrolase-Fc fusion protein for treatment of cocaine abuse.Reward and Toxicity of Cocaine Metabolites Generated by Cocaine Hydrolase.Reaction Pathway and Free Energy Profile for Cocaine Hydrolase-Catalyzed Hydrolysis of (-)-CocaineEffects of anti-cocaine vaccine and viral gene transfer of cocaine hydrolase in mice on cocaine toxicity including motor strength and liver damage.Plants as a source of butyrylcholinesterase variants designed for enhanced cocaine hydrolase activity.Cocaine Hydrolase Gene Transfer Demonstrates Cardiac Safety and Efficacy against Cocaine-Induced QT Prolongation in MiceReply to Curry and Coombs: Benzoic acid is formed predominantly from the benzoyl ester hydrolysis in the presence of cocaine hydrolase.Prospects, promise and problems on the road to effective vaccines and related therapies for substance abuseInterception of cocaine by enzyme or antibody delivered with viral gene transfer: a novel strategy for preventing relapse in recovering drug users.Preclinical studies on neurobehavioral and neuromuscular effects of cocaine hydrolase gene therapy in mice.A highly efficient cocaine-detoxifying enzyme obtained by computational design.Cocaine hydrolase gene therapy for cocaine abuseReaction Pathway for Cocaine Hydrolase-Catalyzed Hydrolysis of (+)-Cocaine.Free energy perturbation simulation on transition states and high-activity mutants of human butyrylcholinesterase for (-)-cocaine hydrolysis.Plant-expressed cocaine hydrolase variants of butyrylcholinesterase exhibit altered allosteric effects of cholinesterase activity and increased inhibitor sensitivityKinetic characterization of a cocaine hydrolase engineered from mouse butyrylcholinesterase.Reaction pathway and free energy profiles for butyrylcholinesterase-catalyzed hydrolysis of acetylthiocholine.Catalytic activities of a cocaine hydrolase engineered from human butyrylcholinesterase against (+)- and (-)-cocaine.Reaction mechanism for cocaine esterase-catalyzed hydrolyses of (+)- and (-)-cocaine: unexpected common rate-determining step.Reaction pathway and free energy profile for butyrylcholinesterase-catalyzed hydrolysis of acetylcholine.Effects of a cocaine hydrolase engineered from human butyrylcholinesterase on metabolic profile of cocaine in rats.Clinical Potential of an Enzyme-based Novel Therapy for Cocaine Overdose.Polyclonal Antibodies in Microplates to Predict the Maximum Adsorption Activities of Enzyme/Mutants from Cell Lysates.Treating Cocaine Addiction, Obesity, and Emotional Disorders by Viral Gene Transfer of Butyrylcholinesterase.
P2860
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P2860
Characterization of a high-activity mutant of human butyrylcholinesterase against (-)-cocaine.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
@yue
2010年學術文章
@zh
2010年學術文章
@zh-hant
name
Characterization of a high-act ...... nesterase against (-)-cocaine.
@en
Characterization of a high-activity mutant of human butyrylcholinesterase against
@nl
type
label
Characterization of a high-act ...... nesterase against (-)-cocaine.
@en
Characterization of a high-activity mutant of human butyrylcholinesterase against
@nl
prefLabel
Characterization of a high-act ...... nesterase against (-)-cocaine.
@en
Characterization of a high-activity mutant of human butyrylcholinesterase against
@nl
P2093
P2860
P1476
Characterization of a high-act ...... nesterase against (-)-cocaine.
@en
P2093
P2860
P304
P356
10.1016/J.CBI.2010.01.004
P577
2010-01-11T00:00:00Z