CENPA overexpression promotes genome instability in pRb-depleted human cells. - Wikidata - awgldk - TriplyDB

CENPA overexpression promotes genome instability in pRb-depleted human cells.

CENPA overexpression promotes genome instability in pRb-depleted human cells.

http://www.wikidata.org/entity/Q39764758

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RB1: a prototype tumor suppressor and an enigma Neocentromeres and epigenetically inherited features of centromeres Disruptive chemicals, senescence and immortality DNA demethylation caused by 5-Aza-2'-deoxycytidine induces mitotic alterations and aneuploidy An E3 ubiquitin ligase prevents ectopic localization of the centromeric histone H3 variant via the centromere targeting domain SUMO-Targeted Ubiquitin Ligase (STUbL) Slx5 regulates proteolysis of centromeric histone H3 variant Cse4 and prevents its mislocalization to euchromatin.Psh1 is an E3 ubiquitin ligase that targets the centromeric histone variant Cse4 Misregulation of Scm3p/HJURP causes chromosome instability in Saccharomyces cerevisiae and human cells.Identification of a predominant co-regulation among kinetochore genes, prospective regulatory elements, and association with genomic instability ShRNA-targeted centromere protein A inhibits hepatocellular carcinoma growth Transgenerational propagation and quantitative maintenance of paternal centromeres depends on Cid/Cenp-A presence in Drosophila sperm A Network-Based Data Integration Approach to Support Drug Repurposing and Multi-Target Therapies in Triple Negative Breast Cancer Assembling pieces of the centromere epigenetics puzzle.CENP-A reduction induces a p53-dependent cellular senescence response to protect cells from executing defective mitoses.Toward a rationale for the PTC124 (Ataluren) promoted readthrough of premature stop codons: a computational approach and GFP-reporter cell-based assay Factors that promote H3 chromatin integrity during transcription prevent promiscuous deposition of CENP-A(Cnp1) in fission yeast The FACT complex interacts with the E3 ubiquitin ligase Psh1 to prevent ectopic localization of CENP-A.Phosphorylation by casein kinase 2 facilitates Psh1 protein-assisted degradation of Cse4 protein Nucleolar organization, ribosomal DNA array stability, and acrocentric chromosome integrity are linked to telomere function.Mechanisms of environmental chemicals that enable the cancer hallmark of evasion of growth suppression.Biomolecular events in cancer revealed by attractor metagenes.Ectopic centromere nucleation by CENP--a in fission yeast.CENP-A nucleosomes localize to transcription factor hotspots and subtelomeric sites in human cancer cells Loss of the N-terminal methyltransferase NRMT1 increases sensitivity to DNA damage and promotes mammary oncogenesis Flexibility of centromere and kinetochore structures.Implications of aneuploidy for stem cell biology and brain therapeutics Overexpression of centromere protein K (CENPK) in ovarian cancer is correlated with poor patient survival and associated with predictive and prognostic relevance.The F-box Protein Rcy1 Is Involved in the Degradation of Histone H3 Variant Cse4 and Genome Maintenance A double-edged sword: how oncogenes and tumor suppressor genes can contribute to chromosomal instability Chromatin assembly: Journey to the CENter of the chromosome Immunohistochemical Assessment of Expression of Centromere Protein-A (CENPA) in Human Invasive Breast Cancer.Cancer upregulated gene 2 induces epithelial-mesenchymal transition of human lung cancer cells via TGF-β signaling.Adipose-derived Mesenchymal Stem Cells (ASCs) may favour breast cancer recurrence via HGF/c-Met signaling.pRB, a tumor suppressor with a stabilizing presence.RB: mitotic implications of a tumour suppressor.The evolutionary life cycle of the resilient centromere.Chromatin dynamics: H3K4 methylation and H3 variant replacement during development and in cancer.The histone chaperone HJURP is a new independent prognostic marker for luminal A breast carcinoma.ABCG2 is a potential marker of tumor-initiating cells in breast cancer.Histone H4 Facilitates the Proteolysis of the Budding Yeast CENP-ACse4 Centromeric Histone Variant.

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P2860

CENPA overexpression promotes genome instability in pRb-depleted human cells.

http://www.wikidata.org/entity/Q39764758

description

2009 nî lūn-bûn

@nan

2009年の論文

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年學術文章

@yue

2009年學術文章

@zh

2009年學術文章

@zh-hant

name

CENPA overexpression promotes genome instability in pRb-depleted human cells.

@en

CENPA overexpression promotes genome instability in pRb-depleted human cells.

@nl

type

label

CENPA overexpression promotes genome instability in pRb-depleted human cells.

@en

CENPA overexpression promotes genome instability in pRb-depleted human cells.

@nl

prefLabel

CENPA overexpression promotes genome instability in pRb-depleted human cells.

@en

CENPA overexpression promotes genome instability in pRb-depleted human cells.

@nl

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Molecular Cancer

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CENPA overexpression promotes genome instability in pRb-depleted human cells.

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Aldo Di Leonardo

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Angela Amato

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Laura Lentini

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Tiziana Schillaci

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P2860

Specification of kinetochore-forming chromatin by the histone H3 variant CENP-A

Mutations of mitotic checkpoint genes in human cancers

A requirement for breast-cancer-associated gene 1 (BRCA1) in the spindle checkpoint

Overexpression and mistargeting of centromere protein-A in human primary colorectal cancer

A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers

Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation

Requirement for p53 and p21 to sustain G2 arrest after DNA damage

Centromeres and kinetochores: from epigenetics to mitotic checkpoint signaling

On the road to cancer: aneuploidy and the mitotic checkpoint

RNAi mediated acute depletion of retinoblastoma protein (pRb) promotes aneuploidy in human primary cells via micronuclei formation.

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8

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