Mutant rhodopsin transgene expression on a null background.
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Retinal remodeling in human retinitis pigmentosaRhodopsin mutant P23H destabilizes rod photoreceptor disk membranesInactivation of VCP/ter94 suppresses retinal pathology caused by misfolded rhodopsin in DrosophilaThe function of guanylate cyclase 1 and guanylate cyclase 2 in rod and cone photoreceptorsTransport of truncated rhodopsin and its effects on rod function and degeneration.Restoration of visual function in P23H rhodopsin transgenic rats by gene delivery of BiP/Grp78Gene augmentation for adRP mutations in RHO.Photoactivation-induced instability of rhodopsin mutants T4K and T17M in rod outer segments underlies retinal degeneration in X. laevis transgenic models of retinitis pigmentosaDysfunction of heterotrimeric kinesin-2 in rod photoreceptor cells and the role of opsin mislocalization in rapid cell death.Expression of wild-type Rp1 protein in Rp1 knock-in mice rescues the retinal degeneration phenotypeRhodopsin gene expression determines rod outer segment size and rod cell resistance to a dominant-negative neurodegeneration mutantKnock-in human rhodopsin-GFP fusions as mouse models for human disease and targets for gene therapy.G protein-coupled receptor rhodopsin.AAV delivery of wild-type rhodopsin preserves retinal function in a mouse model of autosomal dominant retinitis pigmentosa.Ablation of the proapoptotic genes CHOP or Ask1 does not prevent or delay loss of visual function in a P23H transgenic mouse model of retinitis pigmentosaExclusion of the unfolded protein response in light-induced retinal degeneration in the canine T4R RHO model of autosomal dominant retinitis pigmentosa.Variables and strategies in development of therapeutic post-transcriptional gene silencing agentsDrug-inducible synergistic gene silencing with multiple small hairpin RNA molecules for gene function study in animal model.Retinal laminar architecture in human retinitis pigmentosa caused by Rhodopsin gene mutationsPreservation of photoreceptor morphology and function in P23H rats using an allele independent ribozyme.Targeted inactivation of synaptic HRG4 (UNC119) causes dysfunction in the distal photoreceptor and slow retinal degeneration, revealing a new function.Mislocalization and degradation of human P23H-rhodopsin-GFP in a knockin mouse model of retinitis pigmentosaA High-Throughput Drug Screening Strategy for Detecting Rhodopsin P23H Mutant Rescue and Degradation.Misfolded opsin mutants display elevated β-sheet structure.Induction of endoplasmic reticulum stress genes, BiP and chop, in genetic and environmental models of retinal degenerationModeling the flexural rigidity of rod photoreceptorsSearch for a correlation between telomere length and severity of retinitis pigmentosa due to the dominant rhodopsin Pro23His mutationMolecular chaperones and photoreceptor function.Allele-Specific Inhibition of Rhodopsin With an Antisense Oligonucleotide Slows Photoreceptor Cell DegenerationInherent instability of the retinitis pigmentosa P23H mutant opsin.Rescue of mutant rhodopsin traffic by metformin-induced AMPK activation accelerates photoreceptor degeneration.Misfolded proteins and retinal dystrophies.Retinal remodeling.Gene therapy in animal models of autosomal dominant retinitis pigmentosaCell-based therapeutic strategies for replacement and preservation in retinal degenerative diseases.Molecular basis for photoreceptor outer segment architecture.The heat-shock response co-inducer arimoclomol protects against retinal degeneration in rhodopsin retinitis pigmentosa.Calnexin improves the folding efficiency of mutant rhodopsin in the presence of pharmacological chaperone 11-cis-retinal.Flavonoid allosteric modulation of mutated visual rhodopsin associated with retinitis pigmentosa.Functional rescue of P23H rhodopsin photoreceptors by gene delivery.
P2860
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P2860
Mutant rhodopsin transgene expression on a null background.
description
2001 nî lūn-bûn
@nan
2001 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի մարտին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Mutant rhodopsin transgene expression on a null background.
@ast
Mutant rhodopsin transgene expression on a null background.
@en
type
label
Mutant rhodopsin transgene expression on a null background.
@ast
Mutant rhodopsin transgene expression on a null background.
@en
prefLabel
Mutant rhodopsin transgene expression on a null background.
@ast
Mutant rhodopsin transgene expression on a null background.
@en
P2093
P1476
Mutant rhodopsin transgene expression on a null background.
@en
P2093
Church-Kopish J
Frederick JM
Hoffmann K
Krasnoperova NV
P304
P407
P577
2001-03-01T00:00:00Z