Memantine binding to a superficial site on NMDA receptors contributes to partial trapping.
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Treatment-Resistant Major Depression: Rationale for NMDA Receptors as Targets and Nitrous Oxide as TherapyGlutamate receptor ion channels: structure, regulation, and functionPharmacologically targeted NMDA receptor antagonism by NitroMemantine for cerebrovascular diseaseMechanisms underlying differential effectiveness of memantine and ketamine in rapid antidepressant responses.New targets for rapid antidepressant action.Recent insights into the mode of action of memantine and ketamineInteraction between positive allosteric modulators and trapping blockers of the NMDA receptor channel.Specific sites within the ligand-binding domain and ion channel linkers modulate NMDA receptor gatingRepeated ketamine administration alters N-methyl-D-aspartic acid receptor subunit gene expression: implication of genetic vulnerability for ketamine abuse and ketamine psychosis in humans.Aggression and increased glutamate in the mPFC during withdrawal from intermittent alcohol in outbred miceSynaptic NMDA receptors mediate hypoxic excitotoxic deathAssessing the synergy between cholinomimetics and memantine as augmentation therapy in cognitive impairment in schizophrenia. A virtual human patient trial using quantitative systems pharmacologymTOR activation is required for the anti-alcohol effect of ketamine, but not memantine, in alcohol-preferring ratsAn NMDA receptor gating mechanism developed from MD simulations reveals molecular details underlying subunit-specific contributions.NMDA receptor antagonism: escalation of aggressive behavior in alcohol-drinking miceComparison of behavioral effects of the NMDA receptor channel blockers memantine and ketamine in ratsNMDA Receptor Modulators in the Treatment of Drug Addiction.Indistinguishable synaptic pharmacodynamics of the N-methyl-D-aspartate receptor channel blockers memantine and ketamine.Ketamine: NMDA Receptors and Beyond.Ketamine: promising path or false prophecy in the development of novel therapeutics for mood disorders?Whole-cell patch-clamp analysis of recombinant NMDA receptor pharmacology using brief glutamate applications.Actions of bupivacaine, a widely used local anesthetic, on NMDA receptor responses.Memantine and Ketamine Differentially Alter NMDA Receptor Desensitization.NMDA Receptors in the Central Nervous System.Combined subunit-specific and unspecific inhibition of NMDA receptors triggers distinct cortical c-fos expression patterns.Disease-associated missense mutations in GluN2B subunit alter NMDA receptor ligand binding and ion channel properties.Effects of a ketamine metabolite on synaptic NMDAR function.Ketamine and Ketamine Metabolite Pharmacology: Insights into Therapeutic Mechanisms.
P2860
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P2860
Memantine binding to a superficial site on NMDA receptors contributes to partial trapping.
description
2009 nî lūn-bûn
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name
Memantine binding to a superfi ...... ntributes to partial trapping.
@en
Memantine binding to a superfi ...... ntributes to partial trapping.
@nl
type
label
Memantine binding to a superfi ...... ntributes to partial trapping.
@en
Memantine binding to a superfi ...... ntributes to partial trapping.
@nl
prefLabel
Memantine binding to a superfi ...... ntributes to partial trapping.
@en
Memantine binding to a superfi ...... ntributes to partial trapping.
@nl
P2093
P2860
P1476
Memantine binding to a superfi ...... ntributes to partial trapping.
@en
P2093
Jesse T Wood
Jon W Johnson
Shawn E Kotermanski
P2860
P304
P356
10.1113/JPHYSIOL.2009.176297
P407
P577
2009-08-17T00:00:00Z