Sphingosine kinase 2 deficient tumor xenografts show impaired growth and fail to polarize macrophages towards an anti-inflammatory phenotype.
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The SphKs/S1P/S1PR1 axis in immunity and cancer: more ore to be minedSphingosine-1 Phosphate: A New Modulator of Immune Plasticity in the Tumor MicroenvironmentCharacterization of isoenzyme-selective inhibitors of human sphingosine kinasesDesign, synthesis and biological activity of sphingosine kinase 2 selective inhibitors.Sphingosine kinase type 1 inhibition reveals rapid turnover of circulating sphingosine 1-phosphate.Discovery, biological evaluation, and structure-activity relationship of amidine based sphingosine kinase inhibitorsSphingosine kinase (SphK) 1 and SphK2 play equivalent roles in mediating insulin's mitogenic actionS1P metabolism in cancer and other pathological conditions.Inhibition of sphingosine kinase 2 downregulates the expression of c-Myc and Mcl-1 and induces apoptosis in multiple myeloma.An update on sphingosine-1-phosphate and other sphingolipid mediators.Roles of sphingosine 1-phosphate on tumorigenesisA selective ATP-competitive sphingosine kinase inhibitor demonstrates anti-cancer properties.Sphingosine-1-phosphate signaling and its role in disease.Defining a role for sphingosine kinase 1 in p53-dependent tumors.Intracellular sphingosine kinase 2-derived sphingosine-1-phosphate mediates epidermal growth factor-induced ezrin-radixin-moesin phosphorylation and cancer cell invasion.Shaping the landscape: metabolic regulation of S1P gradients.Apoptotic tumor cells induce IL-27 release from human DCs to activate Treg cells that express CD69 and attenuate cytotoxicity.A novel role of breast cancer-derived hyaluronan on inducement of M2-like tumor-associated macrophages formation.FTY720 inhibits tumor growth and enhances the tumor-suppressive effect of topotecan in neuroblastoma by interfering with the sphingolipid signaling pathwayAntitumor effect of the novel sphingosine kinase 2 inhibitor ABC294640 is enhanced by inhibition of autophagy and by sorafenib in human cholangiocarcinoma cells.An oncogenic role for sphingosine kinase 2.Downregulation of sphingosine kinase-1 induces protective tumor immunity by promoting M1 macrophage response in melanoma.Therapeutic potential of targeting sphingosine kinase 1 in prostate cancer.Oncogenic properties of sphingosine kinases in haematological malignancies.S1P Provokes Tumor Lymphangiogenesis via Macrophage-Derived Mediators Such as IL-1β or Lipocalin-2.Software-assisted morphometric and phenotype analyses of human peripheral blood monocyte-derived macrophages induced by a microenvironment model of human esophageal squamous cell carcinoma.Downregulation of Critical Oncogenes by the Selective SK2 Inhibitor ABC294640 Hinders Prostate Cancer Progression.Therapeutic potential of targeting sphingosine kinases and sphingosine 1-phosphate in hematological malignancies.Ablation of sphingosine kinase-2 inhibits tumor cell proliferation and migration.Sphingosine Kinases and Sphingosine 1-Phosphate Receptors: Signaling and Actions in the Cardiovascular System.Induction of chemokine (C-C motif) ligand 2 by sphingosine-1-phosphate signaling in neuroblastoma.Impact of sphingosine kinase 2 deficiency on the development of TNF-alpha-induced inflammatory arthritis.Sphingosine-1-phosphate signalling induces the production of Lcn-2 by macrophages to promote kidney regeneration.The Role of Sphingosine-1-Phosphate and Ceramide-1-Phosphate in Inflammation and Cancer.SphK2 over-expression promotes osteosarcoma cell growth.Sphingosine kinase 2 supports the development of BCR/ABL-independent acute lymphoblastic leukemia in mice.Sphingolipid pathway enzymes modulate cell fate and immune responses.Increased SPHK2 Transcription of Human Colon Cancer Cells in Serum-Depleted Culture: The Involvement of CREB Transcription Factor.Killing Is Not Enough: How Apoptosis Hijacks Tumor-Associated Macrophages to Promote Cancer Progression.Lipocalin 2 from macrophages stimulated by tumor cell-derived sphingosine 1-phosphate promotes lymphangiogenesis and tumor metastasis.
P2860
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P2860
Sphingosine kinase 2 deficient tumor xenografts show impaired growth and fail to polarize macrophages towards an anti-inflammatory phenotype.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh
2009年學術文章
@zh-hant
name
Sphingosine kinase 2 deficient ...... n anti-inflammatory phenotype.
@en
Sphingosine kinase 2 deficient ...... n anti-inflammatory phenotype.
@nl
type
label
Sphingosine kinase 2 deficient ...... n anti-inflammatory phenotype.
@en
Sphingosine kinase 2 deficient ...... n anti-inflammatory phenotype.
@nl
prefLabel
Sphingosine kinase 2 deficient ...... n anti-inflammatory phenotype.
@en
Sphingosine kinase 2 deficient ...... n anti-inflammatory phenotype.
@nl
P2093
P50
P921
P356
P1476
Sphingosine kinase 2 deficient ...... n anti-inflammatory phenotype.
@en
P2093
Christian Werno
Divya Sekar
Gerd Geisslinger
Heidi Menrad
Sabine Grosch
Stephanie Ley
P304
P356
10.1002/IJC.24594
P577
2009-11-01T00:00:00Z