Reversibility of covalent electrophile-protein adducts and chemical toxicity. - Wikidata - awgldk - TriplyDB

Reversibility of covalent electrophile-protein adducts and chemical toxicity.

Reversibility of covalent electrophile-protein adducts and chemical toxicity.

http://www.wikidata.org/entity/Q39834484

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Endogenous Generation and Signaling Actions of Omega-3 Fatty Acid Electrophilic Derivatives Redox-dependent anti-inflammatory signaling actions of unsaturated fatty acids Bioinformatic analysis of xenobiotic reactive metabolite target proteins and their interacting partners.Activation of vascular endothelial nitric oxide synthase and heme oxygenase-1 expression by electrophilic nitro-fatty acids.Techniques for the analysis of cysteine sulfhydryls and oxidative protein folding.Systems analysis of protein modification and cellular responses induced by electrophile stress.Improving the serum stability of site-specific antibody conjugates with sulfone linkers.Design of reversible, cysteine-targeted Michael acceptors guided by kinetic and computational analysis.Cysteinyl peptide capture for shotgun proteomics: global assessment of chemoselective fractionation.Cyclooxygenase-2 generates anti-inflammatory mediators from omega-3 fatty acids Electrophilic fatty acids regulate matrix metalloproteinase activity and expression.Signaling actions of electrophiles: anti-inflammatory therapeutic candidates Tunable degradation of maleimide-thiol adducts in reducing environments Fatty acids, inflammation, and asthma Formation and signaling actions of electrophilic lipids Conjugation of glutathione to oxidized tyrosine residues in peptides and proteins.Electrophilic adduction of ubiquitin activating enzyme E1 by N,N-diethyldithiocarbamate inhibits ubiquitin activation and is accompanied by striatal injury in the rat.An overview of the chemistry and biology of reactive aldehydes.Chemical and biological mechanisms of phytochemical activation of Nrf2 and importance in disease prevention Simple synthesis of 1,3-cyclopentanedione derived probes for labeling sulfenic acid proteins Adverse Outcomes Associated with Cigarette Smoke Radicals Related to Damage to Protein-disulfide Isomerase Characterization and quantification of endogenous fatty acid nitroalkene metabolites in human urine.Synthesis and SAR studies of 5-(pyridin-4-yl)-1,3,4-thiadiazol-2-amine derivatives as potent inhibitors of Bloom helicase.Detection of electrophile-sensitive proteins.Rapid, stable, chemoselective labeling of thiols with Julia-Kocieński-like reagents: a serum-stable alternative to maleimide-based protein conjugation.Application of catalyst-free click reactions in attaching affinity molecules to tips of atomic force microscopy for detection of protein biomarkers.Quantification of thiols and disulfides.Prediction of hypersensitivity to antibiotics: what factors need to be considered?Antibody-Drug Conjugates: Design, Formulation and Physicochemical Stability.Systematic and quantitative assessment of hydrogen peroxide reactivity with cysteines across human proteomes.Targeted Covalent Inhibitors for Drug Design.Half-Life Extension of Biopharmaceuticals using Chemical Methods: Alternatives to PEGylation.Evaluation of surface/interface-related physicochemical and microstructural properties of gelatin 3D scaffolds, and their influence on fibroblast growth and morphology.Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates.Quantitative chemoproteomics for site-specific analysis of protein alkylation by 4-hydroxy-2-nonenal in cells.Nitro-fatty acid inhibition of triple negative breast cancer cell viability, migration, invasion and tumor growth.Electrophilic nitro-fatty acids suppress allergic contact dermatitis in mice.Electrophilic fatty acid nitroalkenes regulate Nrf2 and NF-κB signaling:A medicinal chemistry investigation of structure-function relationships.Immunoprecipitation middle-up LC-MS for in vivo drug-to-antibody ratio determination for antibody-drug conjugates.Insights on Localized and Systemic Delivery of Redox-Based Therapeutics.

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P2860

Reversibility of covalent electrophile-protein adducts and chemical toxicity.

http://www.wikidata.org/entity/Q39834484

description

2008 nî lūn-bûn

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2008年の論文

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2008年学术文章

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2008年学术文章

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2008年学术文章

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2008年学术文章

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2008年学术文章

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2008年學術文章

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2008年學術文章

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2008年學術文章

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name

Reversibility of covalent electrophile-protein adducts and chemical toxicity.

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Reversibility of covalent electrophile-protein adducts and chemical toxicity.

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type

label

Reversibility of covalent electrophile-protein adducts and chemical toxicity.

@en

Reversibility of covalent electrophile-protein adducts and chemical toxicity.

@nl

prefLabel

Reversibility of covalent electrophile-protein adducts and chemical toxicity.

@en

Reversibility of covalent electrophile-protein adducts and chemical toxicity.

@nl

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Chemical Research in Toxicology

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Reversibility of covalent electrophile-protein adducts and chemical toxicity.

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P2093

De Lin

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Samir Saleh

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P2860

A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution

Covalent modification at Cys151 dissociates the electrophile sensor Keap1 from the ubiquitin ligase CUL3

Protein adducts generated from products of lipid oxidation: focus on HNE and one.

Protein damage by reactive electrophiles: targets and consequences

Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2

Endogenous generation of reactive oxidants and electrophiles and their reactions with DNA and protein.

Drug-protein adducts: an industry perspective on minimizing the potential for drug bioactivation in drug discovery and development.

Sites of alkylation of human Keap1 by natural chemoprevention agents.

The role of Keap1 in cellular protective responses.

Future of toxicology-metabolic activation and drug design: challenges and opportunities in chemical toxicology.

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2361-2369

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scholarly article

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10.1021/TX800248X

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12

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21

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Daniel C. Liebler

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2008-12-01T00:00:00Z

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19548357

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