Pim-1 plays a pivotal role in hypoxia-induced chemoresistance. - Wikidata - awgldk - TriplyDB

Pim-1 plays a pivotal role in hypoxia-induced chemoresistance.

Pim-1 plays a pivotal role in hypoxia-induced chemoresistance.

http://www.wikidata.org/entity/Q39844632

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PIM serine/threonine kinases in the pathogenesis and therapy of hematologic malignancies and solid cancers The Landscape of Pancreatic Cancer Therapeutic Resistance Mechanisms Targeting the Pim kinases in multiple myeloma Association of Nuclear PIM1 Expression with Lymph Node Metastasis and Poor Prognosis in Patients with Lung Adenocarcinoma and Squamous Cell Carcinoma The PIM kinases in hematological cancers PIM1 kinase as a target for cancer therapy Conditional transgenic expression of PIM1 kinase in prostate induces inflammation-dependent neoplasia Hypoxia-induced cytotoxic drug resistance in osteosarcoma is independent of HIF-1Alpha The role of PIM1/PIM2 kinases in tumors of the male reproductive system ERG deregulation induces PIM1 over-expression and aneuploidy in prostate epithelial cells.The mRNA-binding protein HuR promotes hypoxia-induced chemoresistance through posttranscriptional regulation of the proto-oncogene PIM1 in pancreatic cancer cells.The oncogenic kinase Pim-1 is modulated by K-Ras signaling and mediates transformed growth and radioresistance in human pancreatic ductal adenocarcinoma cells.EBNA3C augments Pim-1 mediated phosphorylation and degradation of p21 to promote B-cell proliferation Targeting PIM kinase enhances the activity of sunitinib in renal cell carcinoma.Combinatorial therapy with tamoxifen and trifluoperazine effectively inhibits malignant peripheral nerve sheath tumor growth by targeting complementary signaling cascades.PIM1 regulates glycolysis and promotes tumor progression in hepatocellular carcinoma IL-6 stimulates STAT3 and Pim-1 kinase in pancreatic cancer cell lines.The PI3K/Akt Pathway Regulates Oxygen Metabolism via Pyruvate Dehydrogenase (PDH)-E1α Phosphorylation.Identification and functional characterization of pVHL-dependent cell surface proteins in renal cell carcinoma.Activation of Pim Kinases Is Sufficient to Promote Resistance to MET Small-Molecule Inhibitors.PIM kinases as therapeutic targets against advanced melanoma.Inflammation and survival pathways: chronic lymphocytic leukemia as a model system.The PIM family of serine/threonine kinases in cancer.PIM kinases: an overview in tumors and recent advances in pancreatic cancer.PIM kinase (and Akt) biology and signaling in tumors.PIM Kinase Inhibitors Kill Hypoxic Tumor Cells by Reducing Nrf2 Signaling and Increasing Reactive Oxygen Species.Regulation of prostate stromal fibroblasts by the PIM1 protein kinase.Pim kinase isoforms: devils defending cancer cells from therapeutic and immune attacks.PIM and AKT kinase inhibitors show synergistic cytotoxicity in acute myeloid leukaemia that is associated with convergence on mTOR and MCL1 pathways.Inhibition of oncogenic Pim-3 kinase modulates transformed growth and chemosensitizes pancreatic cancer cells to gemcitabine.Strange Bedfellows: Nuclear Factor, Erythroid 2-Like 2 (Nrf2) and Hypoxia-Inducible Factor 1 (HIF-1) in Tumor Hypoxia.The direct Myc target Pim3 cooperates with other Pim kinases in supporting viability of Myc-induced B-cell lymphomas.Targeted inhibition of mTORC1 and mTORC2 by active-site mTOR inhibitors has cytotoxic effects in T-cell acute lymphoblastic leukemia.Inflammation and stem markers association to PIM1/PIM2 kinase-induced tumors in breast and uterus.The Novel PIM1 Inhibitor NMS-P645 Reverses PIM1-Dependent Effects on TMPRSS2/ERG Positive Prostate Cancer Cells And Shows Anti-Proliferative Activity in Combination with PI3K Inhibition.Linking off-target kinase pharmacology to the differential cellular effects observed among PARP inhibitors.Rational cotargeting of Pim-1 and Akt in prostate cancer.STAT3 but Not HIF-1α Is Important in Mediating Hypoxia-Induced Chemoresistance in MDA-MB-231, a Triple Negative Breast Cancer Cell Line.HIF1 regulates WSB-1 expression to promote hypoxia-induced chemoresistance in hepatocellular carcinoma cells.Microenvironment-induced PIM kinases promote CXCR4-triggered mTOR pathway required for chronic lymphocytic leukaemia cell migration.

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Pim-1 plays a pivotal role in hypoxia-induced chemoresistance.

http://www.wikidata.org/entity/Q39844632

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name

Pim-1 plays a pivotal role in hypoxia-induced chemoresistance.

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Pim-1 plays a pivotal role in hypoxia-induced chemoresistance.

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type

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Pim-1 plays a pivotal role in hypoxia-induced chemoresistance.

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Pim-1 plays a pivotal role in hypoxia-induced chemoresistance.

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Pim-1 plays a pivotal role in hypoxia-induced chemoresistance.

@en

Pim-1 plays a pivotal role in hypoxia-induced chemoresistance.

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P2860

Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

Docking study yields four novel inhibitors of the protooncogene Pim-1 kinase

The PIM-2 kinase phosphorylates BAD on serine 112 and reverses BAD-induced cell death

Phosphorylation of the cell cycle inhibitor p21Cip1/WAF1 by Pim-1 kinase

Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response

Perspectives on oxygen sensing.

Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death.

Intermittent hypoxia is a key regulator of cancer cell and endothelial cell interplay in tumours.

Hypoxia-mediated up-regulation of Pim-1 contributes to solid tumor formation.

Hypoxia enhances the expression of autocrine motility factor and the motility of human pancreatic cancer cells

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