Rapamycin specifically interferes with the developmental response of fission yeast to starvation.
about
Rapamycin and less immunosuppressive analogs are toxic to Candida albicans and Cryptococcus neoformans via FKBP12-dependent inhibition of TORThe TOR signaling cascade regulates gene expression in response to nutrientsThe yeast Tor signaling pathway is involved in G2/M transition via polo-kinase.Rapamycin antifungal action is mediated via conserved complexes with FKBP12 and TOR kinase homologs in Cryptococcus neoformans.Fission yeast TORC1 regulates phosphorylation of ribosomal S6 proteins in response to nutrients and its activity is inhibited by rapamycin.The TOR signal transduction cascade controls cellular differentiation in response to nutrients.The TOR kinases link nutrient sensing to cell growth.Deletion of the Aspergillus fumigatus gene encoding the Ras-related protein RhbA reduces virulence in a model of Invasive pulmonary aspergillosis.Chemical genomics approach to identify genes associated with sensitivity to rapamycin in the fission yeast Schizosaccharomyces pombe.Altered nuclear tRNA metabolism in La-deleted Schizosaccharomyces pombe is accompanied by a nutritional stress response involving Atf1p and Pcr1p that is suppressible by Xpo-t/Los1pFission Yeast SCYL1/2 Homologue Ppk32: A Novel Regulator of TOR Signalling That Governs Survival during Brefeldin A Induced Stress to Protein Trafficking.Nutrient Control of Yeast Gametogenesis Is Mediated by TORC1, PKA and Energy AvailabilityProtein kinase activity and identification of a toxic effector domain of the target of rapamycin TOR proteins in yeast.Lack of tRNA modification isopentenyl-A37 alters mRNA decoding and causes metabolic deficiencies in fission yeast.TORC1 signaling is governed by two negative regulators in fission yeast.Torin1-mediated TOR kinase inhibition reduces Wee1 levels and advances mitotic commitment in fission yeast and HeLa cellsNutrient limitations alter cell division control and chromosome segregation through growth-related kinases and phosphatases.Loss of the TOR kinase Tor2 mimics nitrogen starvation and activates the sexual development pathway in fission yeast.TORC1-Dependent Phosphorylation Targets in Fission YeastIsp7 is a novel regulator of amino acid uptake in the TOR signaling pathway.fhl1 gene of the fission yeast regulates transcription of meiotic genes and nitrogen starvation response, downstream of the TORC1 pathway.TORC1 Regulates Developmental Responses to Nitrogen Stress via Regulation of the GATA Transcription Factor Gaf1.Opposite effects of tor1 and tor2 on nitrogen starvation responses in fission yeastThe reverse, but coordinated, roles of Tor2 (TORC1) and Tor1 (TORC2) kinases for growth, cell cycle and separase-mediated mitosis in Schizosaccharomyces pombe.TOR complex 2 controls gene silencing, telomere length maintenance, and survival under DNA-damaging conditions.Glucose activates TORC2-Gad8 protein via positive regulation of the cAMP/cAMP-dependent protein kinase A (PKA) pathway and negative regulation of the Pmk1 protein-mitogen-activated protein kinase pathway.Conservation of the Tsc/Rheb/TORC1/S6K/S6 Signaling in Fission Yeast.Regulation of leucine uptake by tor1+ in Schizosaccharomyces pombe is sensitive to rapamycin.The fission yeast TOR homolog, tor1+, is required for the response to starvation and other stresses via a conserved serine.Rapamycin blocks sexual development in fission yeast through inhibition of the cellular function of an FKBP12 homolog.Fission yeast TOR signaling is essential for the down-regulation of a hyperactivated stress-response MAP kinase under salt stress.Inhibition of target of rapamycin signaling by rapamycin in the unicellular green alga Chlamydomonas reinhardtii.The contribution of non-essential Schizosaccharomyces pombe genes to fitness in response to altered nutrient supply and target of rapamycin activity.
P2860
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P2860
Rapamycin specifically interferes with the developmental response of fission yeast to starvation.
description
1997 nî lūn-bûn
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1997年の論文
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1997年学术文章
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1997年学术文章
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1997年学术文章
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1997年学术文章
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1997年学术文章
@zh-sg
1997年學術文章
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1997年學術文章
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1997年學術文章
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name
Rapamycin specifically interfe ...... f fission yeast to starvation.
@en
Rapamycin specifically interfe ...... f fission yeast to starvation.
@nl
type
label
Rapamycin specifically interfe ...... f fission yeast to starvation.
@en
Rapamycin specifically interfe ...... f fission yeast to starvation.
@nl
prefLabel
Rapamycin specifically interfe ...... f fission yeast to starvation.
@en
Rapamycin specifically interfe ...... f fission yeast to starvation.
@nl
P2093
P2860
P1476
Rapamycin specifically interfe ...... f fission yeast to starvation.
@en
P2093
P2860
P304
P356
10.1128/JB.179.20.6325-6334.1997
P577
1997-10-01T00:00:00Z