about
Crosstalk between leukemia-associated proteins MOZ and MLL regulates HOX gene expression in human cord blood CD34+ cellsInteraction of heat-shock protein 90 beta isoform (HSP90 beta) with cellular inhibitor of apoptosis 1 (c-IAP1) is required for cell differentiationProteolytic regulation of Forkhead transcription factor FOXO3a by caspase-3-like proteasesThe small heat shock protein B8 (HSPB8) confers resistance to bortezomib by promoting autophagic removal of misfolded proteins in multiple myeloma cells.Severe thymic atrophy in a mouse model of skin inflammation accounts for impaired TNFR1 signaling.Leukemic cell xenograft in zebrafish embryo for investigating drug efficacy.Escherichia coli α-hemolysin counteracts the anti-virulence innate immune response triggered by the Rho GTPase activating toxin CNF1 during bacteremia.The PRKAA1/AMPKα1 pathway triggers autophagy during CSF1-induced human monocyte differentiation and is a potential target in CMMLThe anti-apoptotic Bcl-B protein inhibits BECN1-dependent autophagic cell death.Pim kinases modulate resistance to FLT3 tyrosine kinase inhibitors in FLT3-ITD acute myeloid leukemia.Simalikalactone E (SkE), a new weapon in the armamentarium of drugs targeting cancers that exhibit constitutive activation of the ERK pathway.A role for caspases in the differentiation of erythroid cells and macrophages.BCL-B (BCL2L10) is overexpressed in patients suffering from multiple myeloma (MM) and drives an MM-like disease in transgenic miceDifferentiation inducing factor 3 mediates its anti-leukemic effect through ROS-dependent DRP1-mediated mitochondrial fission and induction of caspase-independent cell deathInhibiting glutamine uptake represents an attractive new strategy for treating acute myeloid leukemia.Cleavage of Mcl-1 by caspases impaired its ability to counteract Bim-induced apoptosis.Fine-tuning nucleophosmin in macrophage differentiation and activation.CD271 is an imperfect marker for melanoma initiating cells.Phenotypic and genotypic characterization of azacitidine-sensitive and resistant SKM1 myeloid cell lines.Imatinib triggers mesenchymal-like conversion of CML cells associated with increased aggressiveness.Persistent activation of the Fyn/ERK kinase signaling axis mediates imatinib resistance in chronic myelogenous leukemia cells through upregulation of intracellular SPARC.Inhibition of imatinib-mediated apoptosis by the caspase-cleaved form of the tyrosine kinase Lyn in chronic myelogenous leukemia cells.Modulation of caspase-independent cell death leads to resensitization of imatinib mesylate-resistant cells.Imatinib mesylate-resistant human chronic myelogenous leukemia cell lines exhibit high sensitivity to the phytoalexin resveratrol.Apoptosis and erythroid differentiation triggered by Bcr-Abl inhibitors in CML cell lines are fully distinguishable processes that exhibit different sensitivity to caspase inhibition.A survey of the signaling pathways involved in megakaryocytic differentiation of the human K562 leukemia cell line by molecular and c-DNA array analysis.Imatinib mesylate (STI571) decreases the vascular endothelial growth factor plasma concentration in patients with chronic myeloid leukemia.Imatinib induces mitochondria-dependent apoptosis of the Bcr-Abl-positive K562 cell line and its differentiation toward the erythroid lineage.Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function.Proper macrophagic differentiation requires both autophagy and caspase activation.Endocytosis of resveratrol via lipid rafts and activation of downstream signaling pathways in cancer cells.A new posttranslational regulation of REDD1/DDIT4 through cleavage by caspase 3 modifies its cellular function.DNA Damage and the Activation of the p53 Pathway Mediate Alterations in Metabolic and Secretory Functions of Adipocytes.Alpha-defensins secreted by dysplastic granulocytes inhibit the differentiation of monocytes in chronic myelomonocytic leukemia.Mechanism of action of the multikinase inhibitor Foretinib.Gene expression profiling of imatinib and PD166326-resistant CML cell lines identifies Fyn as a gene associated with resistance to BCR-ABL inhibitors.RhoA GTPase inactivation by statins induces osteosarcoma cell apoptosis by inhibiting p42/p44-MAPKs-Bcl-2 signaling independently of BMP-2 and cell differentiation.p44 mitogen-activated protein kinase (extracellular signal-regulated kinase 1)-dependent signaling contributes to epithelial skin carcinogenesis.RSK2 is a new Pim2 target with pro-survival functions in FLT3-ITD-positive acute myeloid leukemia.CXCL7 is a predictive marker of sunitinib efficacy in clear cell renal cell carcinomas.
P50
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P50
description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Arnaud Jacquel
@ast
Arnaud Jacquel
@en
Arnaud Jacquel
@es
Arnaud Jacquel
@nl
Arnaud Jacquel
@sl
type
label
Arnaud Jacquel
@ast
Arnaud Jacquel
@en
Arnaud Jacquel
@es
Arnaud Jacquel
@nl
Arnaud Jacquel
@sl
prefLabel
Arnaud Jacquel
@ast
Arnaud Jacquel
@en
Arnaud Jacquel
@es
Arnaud Jacquel
@nl
Arnaud Jacquel
@sl
P1053
O-1928-2017
P106
P21
P31
P3829
P496
0000-0001-5062-8048