Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function.
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Evidence that Ser87 of BimEL is phosphorylated by Akt and regulates BimEL apoptotic functionERK1/2-dependent phosphorylation of BimEL promotes its rapid dissociation from Mcl-1 and Bcl-xLEndoplasmic reticulum stress: cell life and death decisions.Development, migration, and survival of mast cellsExtracellular signal-regulated kinases phosphorylate mitogen-activated protein kinase phosphatase 3/DUSP6 at serines 159 and 197, two sites critical for its proteasomal degradationThe Bcl-2 apoptotic switch in cancer development and therapyRoles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistanceRegulation of Bim in Health and DiseaseThe BCL2 Family: Key Mediators of the Apoptotic Response to Targeted Anticancer TherapeuticsModulation of apoptosis sensitivity through the interplay with autophagic and proteasomal degradation pathwaysHow cell death shapes cancerThe deubiquitinase Usp27x stabilizes the BH3-only protein Bim and enhances apoptosisbetaTrCP- and Rsk1/2-mediated degradation of BimEL inhibits apoptosisA protein kinase Cdelta-dependent protein kinase D pathway modulates ERK1/2 and JNK1/2 phosphorylation and Bim-associated apoptosis by asbestosGefitinib-induced killing of NSCLC cell lines expressing mutant EGFR requires BIM and can be enhanced by BH3 mimeticsBax activation initiates the assembly of a multimeric catalyst that facilitates Bax pore formation in mitochondrial outer membranesOncogenic kit triggers Shp2/Erk1/2 pathway to down-regulate the pro-apoptotic protein Bim and to promote apoptosis resistance in leukemic cellsThe conformational control inhibitor of tyrosine kinases DCC-2036 is effective for imatinib-resistant cells expressing T674I FIP1L1-PDGFRαIL-7 Receptor Mutations and Steroid Resistance in Pediatric T cell Acute Lymphoblastic Leukemia: A Genome Sequencing StudyIntrinsically disordered proteins in bcl-2 regulated apoptosis.N-cadherin mediates neuronal cell survival through Bim down-regulation.Activation of MEK1 or MEK2 isoform is sufficient to fully transform intestinal epithelial cells and induce the formation of metastatic tumorsProsurvival and proapoptotic functions of ERK1/2 activation in murine thymocytes in vitro.ETS-targeted therapy: can it substitute for MEK inhibitors?Bortezomib induces apoptosis in primitive chronic myeloid leukemia cells including LTC-IC and NOD/SCID repopulating cells.The Erk2 MAPK regulates CD8 T cell proliferation and survival.Apoptosis induced by JAK2 inhibition is mediated by Bim and enhanced by the BH3 mimetic ABT-737 in JAK2 mutant human erythroid cells.Bim and Mcl-1 exert key roles in regulating JAK2V617F cell survival.Role for the proapoptotic factor BIM in mediating imatinib-induced apoptosis in a c-KIT-dependent gastrointestinal stromal tumor cell lineG1/S cell cycle arrest provides anoikis resistance through Erk-mediated Bim suppression.Bim regulation of lumen formation in cultured mammary epithelial acini is targeted by oncogenes.Defective ubiquitin-mediated degradation of antiapoptotic Bfl-1 predisposes to lymphoma.Rational combination of dual PI3K/mTOR blockade and Bcl-2/-xL inhibition in AML.Evaluation of apoptosis induction by concomitant inhibition of MEK, mTOR, and Bcl-2 in human acute myelogenous leukemia cells.NrasG12D oncoprotein inhibits apoptosis of preleukemic cells expressing Cbfβ-SMMHC via activation of MEK/ERK axis.CAML regulates Bim-dependent thymocyte death.The MEK-ERK pathway negatively regulates bim expression through the 3' UTR in sympathetic neurons.Contracting the 'mus cells'--does down-sizing suit us for diving into the memory pool?A requirement for sustained ERK signaling during thymocyte positive selection in vivo.Bim nuclear translocation and inactivation by viral interferon regulatory factor.
P2860
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P2860
Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
Phosphorylation of Bim-EL by E ...... tes its proapoptotic function.
@en
type
label
Phosphorylation of Bim-EL by E ...... tes its proapoptotic function.
@en
prefLabel
Phosphorylation of Bim-EL by E ...... tes its proapoptotic function.
@en
P2093
P50
P356
P1433
P1476
Phosphorylation of Bim-EL by E ...... ates its proapoptotic function
@en
P2093
Gilles Pages
Magali Herrant
Pascal Colosetti
Sebastien Cagnol
P2888
P304
P356
10.1038/SJ.ONC.1206792
P407
P577
2003-10-01T00:00:00Z
P5875
P6179
1019088501