Binding to gating transduction in nicotinic receptors: Cys-loop energetically couples to pre-M1 and M2-M3 regions
about
End-plate acetylcholine receptor: structure, mechanism, pharmacology, and diseaseSize matters in activation/inhibition of ligand-gated ion channelsPathways and Barriers for Ion Translocation through the 5-HT3A Receptor ChannelSignal Transduction Pathways in the Pentameric Ligand-Gated Ion ChannelsSignal Transduction at the Domain Interface of Prokaryotic Pentameric Ligand-Gated Ion ChannelsGlycine receptor mouse mutants: model systems for human hyperekplexiaThe activation mechanism of alpha1beta2gamma2S and alpha3beta3gamma2S GABAA receptors.The role of intracellular linkers in gating and desensitization of human pentameric ligand-gated ion channelsUnresponsive correlated motion in alpha7 nAChR to halothane binding explains its functional insensitivity to volatile anesthetics.β Subunit M2-M3 loop conformational changes are uncoupled from α1 β glycine receptor channel gating: implications for human hereditary hyperekplexia.Structure-function study of the fourth transmembrane segment of the GABAρ1 receptor.Nicotinic acetylcholine receptor and the structural basis of neuromuscular transmission: insights from Torpedo postsynaptic membranesSubunit symmetry at the extracellular domain-transmembrane domain interface in acetylcholine receptor channel gating.Therapeutics of 5-HT3 receptor antagonists: current uses and future directions.Energetic contributions to channel gating of residues in the muscle nicotinic receptor β1 subunit.Subunit interfaces contribute differently to activation and allosteric modulation of neuronal nicotinic acetylcholine receptors.Incompatibility between a pair of residues from the pre-M1 linker and Cys-loop blocks surface expression of the glycine receptorPotentiation of Neuronal Nicotinic Receptors by 17β-Estradiol: Roles of the Carboxy-Terminal and the Amino-Terminal Extracellular DomainsDistinct properties of glycine receptor β+/α- interface: unambiguously characterizing heteromeric interface reconstituted in homomeric proteinMyasthenic syndrome AChRα C-loop mutant disrupts initiation of channel gatingFunction of hyperekplexia-causing α1R271Q/L glycine receptors is restored by shifting the affected residue out of the allosteric signalling pathwayNMR resolved multiple anesthetic binding sites in the TM domains of the α4β2 nAChRNicotinic receptor transduction zone: invariant arginine couples to multiple electron-rich residues.Subunit stoichiometry and arrangement in a heteromeric glutamate-gated chloride channel.Loop C and the mechanism of acetylcholine receptor-channel gating.Role of the Fourth Transmembrane α Helix in the Allosteric Modulation of Pentameric Ligand-Gated Ion Channels.Improved resolution of single channel dwell times reveals mechanisms of binding, priming, and gating in muscle AChR.Functional relationships between agonist binding sites and coupling regions of homomeric Cys-loop receptorsIn pursuit of the high-resolution structure of nicotinic acetylcholine receptors.The structural basis of function in Cys-loop receptors.Synaptic neurotransmitter-gated receptorsProbing pore constriction in a ligand-gated ion channel by trapping a metal ion in the pore upon agonist dissociation.Intramembrane aromatic interactions influence the lipid sensitivities of pentameric ligand-gated ion channels.Trapping of ivermectin by a pentameric ligand-gated ion channel upon open-to-closed isomerization.Enhanced meta-analysis of acetylcholine binding protein structures reveals conformational signatures of agonism in nicotinic receptors.Mutational Analysis at Intersubunit Interfaces of an Anionic Glutamate Receptor Reveals a Key Interaction Important for Channel Gating by Ivermectin.Study, by use of coarse-grained models, of the functionally crucial residues and allosteric pathway of anesthetic regulation of the Gloeobacter violaceus ligand-gated ion channel.Dipicrylamine Modulates GABAρ1 Receptors through Interactions with Residues in the TM4 and Cys-Loop Domains.Agrin-LRP4-MuSK signaling as a therapeutic target for myasthenia gravis and other neuromuscular disorders.Role of the Cys Loop and Transmembrane Domain in the Allosteric Modulation of α4β2 Nicotinic Acetylcholine Receptors.
P2860
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P2860
Binding to gating transduction in nicotinic receptors: Cys-loop energetically couples to pre-M1 and M2-M3 regions
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
Binding to gating transduction ...... es to pre-M1 and M2-M3 regions
@en
Binding to gating transduction ...... s to pre-M1 and M2-M3 regions.
@nl
type
label
Binding to gating transduction ...... es to pre-M1 and M2-M3 regions
@en
Binding to gating transduction ...... s to pre-M1 and M2-M3 regions.
@nl
prefLabel
Binding to gating transduction ...... es to pre-M1 and M2-M3 regions
@en
Binding to gating transduction ...... s to pre-M1 and M2-M3 regions.
@nl
P2093
P2860
P1476
Binding to gating transduction ...... es to pre-M1 and M2-M3 regions
@en
P2093
Chris R Free
Steven M Sine
Won Yong Lee
P2860
P304
P356
10.1523/JNEUROSCI.6185-08.2009
P407
P577
2009-03-01T00:00:00Z