Herpes simplex virus type 1 glycoprotein K is not essential for infectious virus production in actively replicating cells but is required for efficient envelopment and translocation of infectious virions from the cytoplasm to the extracellular space
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The protein encoded by the US3 orthologue of Marek's disease virus is required for efficient de-envelopment of perinuclear virions and involved in actin stress fiber breakdownTegument Assembly and Secondary Envelopment of AlphaherpesvirusesIdentification of an essential domain in the herpes simplex virus 1 UL34 protein that is necessary and sufficient to interact with UL31 protein.Evidence that herpes simplex virus VP16 is required for viral egress downstream of the initial envelopment event.Glycoprotein K specified by herpes simplex virus type 1 is expressed on virions as a Golgi complex-dependent glycosylated species and functions in virion entryHerpes simplex virus 1 protein UL37 interacts with viral glycoprotein gK and membrane protein UL20 and functions in cytoplasmic virion envelopment.Multiplex sequencing of seven ocular herpes simplex virus type-1 genomes: phylogeny, sequence variability, and SNP distributionAmino acid differences in glycoproteins B (gB), C (gC), H (gH) and L (gL) are associated with enhanced herpes simplex virus type-1 (McKrae) entry via the paired immunoglobulin-like type-2 receptor α.The amino terminus of herpes simplex virus 1 glycoprotein K is required for virion entry via the paired immunoglobulin-like type-2 receptor alphaUltrastructural localization of the herpes simplex virus type 1 UL31, UL34, and US3 proteins suggests specific roles in primary envelopment and egress of nucleocapsids.Plasma membrane topology of syncytial domains of herpes simplex virus type 1 glycoprotein K (gK): the UL20 protein enables cell surface localization of gK but not gK-mediated cell-to-cell fusionMutations within the pathogenic region of herpes simplex virus 1 gK signal sequences alter cell surface expression and neurovirulenceGenetic analysis of the herpes simplex virus type 1 UL20 protein domains involved in cytoplasmic virion envelopment and virus-induced cell fusion.Site-specific proteolytic cleavage of the amino terminus of herpes simplex virus glycoprotein K on virion particles inhibits virus entry.Efficient generation and rapid isolation via stoplight recombination of Herpes simplex viruses expressing model antigenic and immunological epitopes.Identification of non-essential loci within the Meleagrid herpesvirus 1 genome.A herpes simplex virus 1 (McKrae) mutant lacking the glycoprotein K gene is unable to infect via neuronal axons and egress from neuronal cell bodies.The herpes simplex virus UL20 protein functions in glycoprotein K (gK) intracellular transport and virus-induced cell fusion are independent of UL20 functions in cytoplasmic virion envelopmentFunctional and physical interactions of the herpes simplex virus type 1 UL20 membrane protein with glycoprotein KThe amino terminus of herpes simplex virus type 1 glycoprotein K (gK) modulates gB-mediated virus-induced cell fusion and virion egress.Herpes simplex virus type 1 glycoprotein K and the UL20 protein are interdependent for intracellular trafficking and trans-Golgi network localizationThe herpes simplex virus type 1 UL20 protein modulates membrane fusion events during cytoplasmic virion morphogenesis and virus-induced cell fusion.Herpes simplex virus type 1 gK is required for gB-mediated virus-induced cell fusion, while neither gB and gK nor gB and UL20p function redundantly in virion de-envelopmentCellular Protein WDR11 Interacts with Specific Herpes Simplex Virus Proteins at the trans-Golgi Network To Promote Virus Replication.The role of equine herpesvirus type 4 glycoprotein k in virus replication.Functional hierarchy of herpes simplex virus 1 viral glycoproteins in cytoplasmic virion envelopment and egressPrimary envelopment of pseudorabies virus at the nuclear membrane requires the UL34 gene product.Characterization of Varicella-Zoster virus glycoprotein K (open reading frame 5) and its role in virus growthPseudorabies virus glycoprotein gK is a virion structural component involved in virus release but is not required for entry.Pseudorabies virus glycoprotein K requires the UL20 gene product for processing.Herpes simplex virus type 1 U(L)34 gene product is required for viral envelopment.Pseudorabies virus glycoprotein M inhibits membrane fusion.Genetic analysis of the role of herpes simplex virus type 1 glycoprotein K in infectious virus production and egress.Deletion of a Predicted β-Sheet Domain within the Amino Terminus of Herpes Simplex Virus Glycoprotein K Conserved among Alphaherpesviruses Prevents Virus Entry into Neuronal Axons.Herpes simplex virus glycoprotein K, but not its syncytial allele, inhibits cell-cell fusion mediated by the four fusogenic glycoproteins, gD, gB, gH, and gL.Binding of Herpes Simplex Virus 1 UL20 to GODZ (DHHC3) Affects Its Palmitoylation and Is Essential for Infectivity and Proper Targeting and Localization of UL20 and Glycoprotein K.UL20 protein functions precede and are required for the UL11 functions of herpes simplex virus type 1 cytoplasmic virion envelopment.Herpes Simplex Virus 1 UL37 Protein Tyrosine Residues Conserved among All Alphaherpesviruses Are Required for Interactions with Glycoprotein K, Cytoplasmic Virion Envelopment, and Infectious Virus Production.Coexpression of UL20p and gK inhibits cell-cell fusion mediated by herpes simplex virus glycoproteins gD, gH-gL, and wild-type gB or an endocytosis-defective gB mutant and downmodulates their cell surface expression.HSV-1 gM and the gK/pUL20 complex are important for the localization of gD and gH/L to viral assembly sites.
P2860
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P2860
Herpes simplex virus type 1 glycoprotein K is not essential for infectious virus production in actively replicating cells but is required for efficient envelopment and translocation of infectious virions from the cytoplasm to the extracellular space
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
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1997年学术文章
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1997年学术文章
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1997年学术文章
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1997年學術文章
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1997年學術文章
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1997年學術文章
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name
Herpes simplex virus type 1 gl ...... asm to the extracellular space
@en
Herpes simplex virus type 1 gl ...... asm to the extracellular space
@nl
type
label
Herpes simplex virus type 1 gl ...... asm to the extracellular space
@en
Herpes simplex virus type 1 gl ...... asm to the extracellular space
@nl
prefLabel
Herpes simplex virus type 1 gl ...... asm to the extracellular space
@en
Herpes simplex virus type 1 gl ...... asm to the extracellular space
@nl
P2093
P2860
P1433
P1476
Herpes simplex virus type 1 gl ...... asm to the extracellular space
@en
P2093
K G Kousoulas
S Jayachandra
P2860
P304
P407
P577
1997-07-01T00:00:00Z