An upstream open reading frame regulates translation of GADD34 during cellular stresses that induce eIF2alpha phosphorylation
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Association with endoplasmic reticulum promotes proteasomal degradation of GADD34 proteinTranslational Upregulation of an Individual p21Cip1 Transcript Variant by GCN2 Regulates Cell Proliferation and Survival under Nutrient StressChanges in translational control after pro-apoptotic stressGene expression regulation by upstream open reading frames and human diseaseCellular iron depletion and the mechanisms involved in the iron-dependent regulation of the growth arrest and DNA damage family of genesTcf19 is a novel islet factor necessary for proliferation and survival in the INS-1 β-cell lineInhibition of GADD34, the stress-inducible regulatory subunit of the endoplasmic reticulum stress response, does not enhance functional recovery after spinal cord injuryTranslation of 5' leaders is pervasive in genes resistant to eIF2 repressionTranslational control during endoplasmic reticulum stress beyond phosphorylation of the translation initiation factor eIF2α.Differential regulation of CHOP translation by phosphorylated eIF4E under stress conditions.Stress-sensitive regulation of IFRD1 mRNA decay is mediated by an upstream open reading frameDevelopment of antiproliferative phenylmaleimides that activate the unfolded protein response.Regulation of xCT expression and system x (c) (-) function in neuronal cells.Extensive translatome remodeling during ER stress response in mammalian cellsThe small molecule ISRIB reverses the effects of eIF2α phosphorylation on translation and stress granule assemblyRegulation of sumo mRNA during endoplasmic reticulum stress.Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response.Unfolded Protein Response and PERK Kinase as a New Therapeutic Target in the Pathogenesis of Alzheimer's DiseaseA novel feedback loop regulates the response to endoplasmic reticulum stress via the cooperation of cytoplasmic splicing and mRNA translationCoordinated Regulation of the Neutral Amino Acid Transporter SNAT2 and the Protein Phosphatase Subunit GADD34 Promotes Adaptation to Increased Extracellular Osmolarity.Opposite Effects of M1 and M2 Macrophage Subtypes on Lung Cancer Progression.Ribosome Reinitiation Directs Gene-specific Translation and Regulates the Integrated Stress Response.Genome-wide search for novel human uORFs and N-terminal protein extensions using ribosomal footprintingComparison of mRNA localization and regulation during endoplasmic reticulum stress in Drosophila cells.Differential dynamics of the mammalian mRNA and protein expression response to misfolding stress.ATF4-dependent transcription mediates signaling of amino acid limitation.Resetting translational homeostasis restores myelination in Charcot-Marie-Tooth disease type 1B micePotential for therapeutic manipulation of the UPR in disease.Coordinate regulation of eIF2α phosphorylation by PPP1R15 and GCN2 is required during Drosophila development.The transcription factor network associated with the amino acid response in mammalian cells.Eukaryotic initiation factor 2 phosphorylation and translational control in metabolism.A self-defeating anabolic program leads to β-cell apoptosis in endoplasmic reticulum stress-induced diabetes via regulation of amino acid flux.Nuclear Matrix Protein 4 Is a Novel Regulator of Ribosome Biogenesis and Controls the Unfolded Protein Response via Repression of Gadd34 ExpressionCHOP induces activating transcription factor 5 (ATF5) to trigger apoptosis in response to perturbations in protein homeostasis.Global cellular response to chemotherapy-induced apoptosis.ER-stress in Alzheimer's disease: turning the scale?Repeated Exposure to D-Amphetamine Decreases Global Protein Synthesis and Regulates the Translation of a Subset of mRNAs in the Striatum.Dysregulation of protein synthesis and disease.Exploiting the selectivity of protein phosphatase 1 for pharmacological intervention.New insights into translational regulation in the endoplasmic reticulum unfolded protein response.
P2860
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P2860
An upstream open reading frame regulates translation of GADD34 during cellular stresses that induce eIF2alpha phosphorylation
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
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2009年學術文章
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2009年學術文章
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name
An upstream open reading frame ...... duce eIF2alpha phosphorylation
@en
An upstream open reading frame ...... uce eIF2alpha phosphorylation.
@nl
type
label
An upstream open reading frame ...... duce eIF2alpha phosphorylation
@en
An upstream open reading frame ...... uce eIF2alpha phosphorylation.
@nl
prefLabel
An upstream open reading frame ...... duce eIF2alpha phosphorylation
@en
An upstream open reading frame ...... uce eIF2alpha phosphorylation.
@nl
P2093
P2860
P356
P1476
An upstream open reading frame ...... duce eIF2alpha phosphorylation
@en
P2093
Randal C Cevallos
Yun-Young Lee
P2860
P304
P356
10.1074/JBC.M806735200
P407
P577
2009-01-08T00:00:00Z