A study of monoclonal antibody-producing CHO cell lines: what makes a stable high producer? - Wikidata - awgldk - TriplyDB

A study of monoclonal antibody-producing CHO cell lines: what makes a stable high producer?

A study of monoclonal antibody-producing CHO cell lines: what makes a stable high producer?

http://www.wikidata.org/entity/Q39922200

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Mechanisms underlying epigenetic and transcriptional heterogeneity in Chinese hamster ovary (CHO) cell lines Optimized signal peptides for the development of high expressing CHO cell lines Development of a novel ER stress based selection system for the isolation of highly productive clones Comparison of internal ribosome entry site (IRES) and Furin-2A (F2A) for monoclonal antibody expression level and quality in CHO cells Efficient recombinant production in mammalian cells using a novel IR/MAR gene amplification method Intraclonal protein expression heterogeneity in recombinant CHO cells Recombinant protein expression by targeting pre-selected chromosomal loci.Conserved microRNAs in Chinese hamster ovary cell lines.B-cell display-based one-step method to generate chimeric human IgG monoclonal antibodies Rapid characterization of protein productivity and production stability of CHO cells by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.Production and characterization of chimeric monoclonal antibodies against Burkholderia pseudomallei and B. mallei using the DHFR expression system.Immunogenomic engineering of a plug-and-(dis)play hybridoma platform.Fusion of the Dhfr/Mtx and IR/MAR gene amplification methods produces a rapid and efficient method for stable recombinant protein production.Using molecular markers to characterize productivity in Chinese hamster ovary cell lines.High-sensitivity monoclonal antibodies specific for homoserine lactones protect mice from lethal Pseudomonas aeruginosa infections.An internal ribosome entry site (IRES) mutant library for tuning expression level of multiple genes in mammalian cells.The relationship between mTOR signalling pathway and recombinant antibody productivity in CHO cell lines.Analyzing clonal variation of monoclonal antibody-producing CHO cell lines using an in silico metabolomic platform How a replication origin and matrix attachment region accelerate gene amplification under replication stress in mammalian cells.Transcriptome study and identification of potential marker genes related to the stable expression of recombinant proteins in CHO clones.Identifying bottlenecks in transient and stable production of recombinant monoclonal-antibody sequence variants in Chinese hamster ovary cells FISH-Based Analysis of Clonally Derived CHO Cell Populations Reveals High Probability for Transgene Integration in a Terminal Region of Chromosome 1 (1q13).Evaluating the use of a CpG free promoter for long-term recombinant protein expression stability in Chinese hamster ovary cells.Evaluating the expression profile and stability of different UCOE containing vector combinations in mAb-producing CHO cells Expression Enhancement in Trastuzumab Therapeutic Monoclonal Antibody Production using Genomic Amplification with Methotrexate Multi-omic profiling -of EPO-producing Chinese hamster ovary cell panel reveals metabolic adaptation to heterologous protein production Advances in Mammalian cell line development technologies for recombinant protein production.Matrix attachment region combinations increase transgene expression in transfected Chinese hamster ovary cells Over-expression of secreted proteins from mammalian cell lines.Identifying and engineering promoters for high level and sustainable therapeutic recombinant protein production in cultured mammalian cells.Ubiquitous Chromatin Opening Elements (UCOEs) effect on transgene position and expression stability in CHO cells following methotrexate (MTX) amplification.Epigenetic regulatory elements: Recent advances in understanding their mode of action and use for recombinant protein production in mammalian cells.Genetic analysis of the clonal stability of Chinese hamster ovary cells for recombinant protein production.New Mammalian Expression Systems.Improved CHO Cell Line Stability and Recombinant Protein Expression During Long-Term Culture.A framework to quantify karyotype variation associated with CHO cell line instability at a single-cell level.A humanized chimeric antibody Hai178 targeted to the β subunit of F1F0 ATP synthase.Genetic analyses of Per.C6 cell clones producing a therapeutic monoclonal antibody regarding productivity and long-term stability.Fam60A plays a role for production stabilities of recombinant CHO cell lines.Identifying and retargeting transcriptional hot spots in the human genome.

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A study of monoclonal antibody-producing CHO cell lines: what makes a stable high producer?

http://www.wikidata.org/entity/Q39922200

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2009 nî lūn-bûn

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2009年の論文

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年學術文章

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2009年學術文章

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2009年學術文章

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A study of monoclonal antibody ...... makes a stable high producer?

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Biotechnology and Bioengineering

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A study of monoclonal antibody ...... makes a stable high producer?

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Janet Chusainow

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Jessna H M Yeo

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Miranda G S Yap

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Niki S C Wong

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Parisa Asvadi

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Poh Choo Toh

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Yuan Sheng Yang

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P2860

Effects of methotrexate on transfected DNA stability in mammalian cells.

Homologous plasmid recombination is elevated in immortally transformed cells.

Coamplification and coexpression of human tissue-type plasminogen activator and murine dihydrofolate reductase sequences in Chinese hamster ovary cells.

Evolution of chromosomal regions containing transfected and amplified dihydrofolate reductase sequences.

Moderate-level gene amplification in methotrexate-resistant Chinese hamster ovary cells is accompanied by chromosomal translocations at or near the site of the amplified DHFR gene

Expression of the mouse dihydrofolate reductase complementary deoxyribonucleic acid in simian virus 40 vectors.

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1182-1196

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scholarly article

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10.1002/BIT.22158

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4

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102

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23446962

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18979540

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