Role of the insulin-like growth factor I/insulin receptor substrate 1 axis in Rad51 trafficking and DNA repair by homologous recombination.
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Enhanced phosphorylation of Nbs1, a member of DNA repair/checkpoint complex Mre11-RAD50-Nbs1, can be targeted to increase the efficacy of imatinib mesylate against BCR/ABL-positive leukemia cellsCross talk of tyrosine kinases with the DNA damage signaling pathwaysInhibition of ERβ induces resistance to cisplatin by enhancing Rad51-mediated DNA repair in human medulloblastoma cell linesTargeting RAD51 phosphotyrosine-315 to prevent unfaithful recombination repair in BCR-ABL1 leukemia.Polycyclic aromatic hydrocarbons-induced ROS accumulation enhances mutagenic potential of T-antigen from human polyomavirus JCInsulin receptor substrates (IRSs) and breast tumorigenesis.IGF-IR-dependent expression of Survivin is required for T-antigen-mediated protection from apoptosis and proliferation of neural progenitors.CTCF facilitates DNA double-strand break repair by enhancing homologous recombination repair.BCR/ABL modifies the kinetics and fidelity of DNA double-strand breaks repair in hematopoietic cells.IGF-1 induces expression of zinc-finger protein 143 in colon cancer cells through phosphatidylinositide 3-kinase and reactive oxygen species.Can we unlock the potential of IGF-1R inhibition in cancer therapy?Insulin-like growth factor receptor-1 overexpression is associated with poor response of rectal cancers to radiotherapy.Inhibition of both EGFR and IGF1R sensitized prostate cancer cells to radiation by synergistic suppression of DNA homologous recombination repairThe Molecular Crosstalk between the MET Receptor Tyrosine Kinase and the DNA Damage Response-Biological and Clinical AspectsRegulators of homologous recombination repair as novel targets for cancer treatment.Suppression of Homologous Recombination by insulin-like growth factor-1 inhibition sensitizes cancer cells to PARP inhibitorsEmerging therapies in pancreas cancer.The abundance of Rad51 protein in mouse embryonic stem cells is regulated at multiple levels.IGF-1R inhibition induces schedule-dependent sensitization of human melanoma to temozolomideCollections of simultaneously altered genes as biomarkers of cancer cell drug responseExperimental concepts for toxicity prevention and tissue restoration after central nervous system irradiation.Prospective Study of Human Polyomaviruses and Risk of Cutaneous Squamous Cell Carcinoma in the United StatesInsulin receptor substrate-2 regulates aerobic glycolysis in mouse mammary tumor cells via glucose transporter 1.Expression and function of the insulin receptor substrate proteins in cancerReceptor signaling as a regulatory mechanism of DNA repair.IGF-IR in neuroprotection and brain tumors.GAIP-interacting protein, C-terminus is involved in the induction of zinc-finger protein 143 in response to insulin-like growth factor-1 in colon cancer cellsUrsolic Acid-Regulated Energy Metabolism-Reliever or Propeller of Ultraviolet-Induced Oxidative Stress and DNA Damage?Fibroblast growth factor receptor 4 induced resistance to radiation therapy in colorectal cancer.Beyond ATM: the protein kinase landscape of the DNA damage response.Nuclear IRS-1 and cancerLow-fidelity compensatory backup alternative DNA repair pathways may unify current carcinogenesis theories.IGF-1R inhibition enhances radiosensitivity and delays double-strand break repair by both non-homologous end-joining and homologous recombination.Suppression of homologous recombination sensitizes human tumor cells to IGF-1R inhibition.Fenofibrate-induced nuclear translocation of FoxO3A triggers Bim-mediated apoptosis in glioblastoma cells in vitro.Estrogen receptor beta-mediated nuclear interaction between IRS-1 and Rad51 inhibits homologous recombination directed DNA repair in medulloblastomaMolecular mimicry in inducing DNA damage between HIV-1 Vpr and the anticancer agent, cisplatin.PBK/TOPK promotes tumour cell proliferation through p38 MAPK activity and regulation of the DNA damage response.Ionizing radiation activates IGF-1R triggering a cytoprotective signaling by interfering with Ku-DNA binding and by modulating Ku86 expression via a p38 kinase-dependent mechanism.Inhibition of IGF-I receptor in anchorage-independence attenuates GSK-3beta constitutive phosphorylation and compromises growth and survival of medulloblastoma cell lines.
P2860
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P2860
Role of the insulin-like growth factor I/insulin receptor substrate 1 axis in Rad51 trafficking and DNA repair by homologous recombination.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
Role of the insulin-like growt ...... r by homologous recombination.
@en
Role of the insulin-like growt ...... r by homologous recombination.
@nl
type
label
Role of the insulin-like growt ...... r by homologous recombination.
@en
Role of the insulin-like growt ...... r by homologous recombination.
@nl
prefLabel
Role of the insulin-like growt ...... r by homologous recombination.
@en
Role of the insulin-like growt ...... r by homologous recombination.
@nl
P2093
P2860
P1476
Role of the insulin-like growt ...... ir by homologous recombination
@en
P2093
Adam Lassak
Francesca Peruzzi
Jin Ying Wang
Kamel Khalili
Krzysztof Reiss
Luis Del Valle
Michal Nowicki
Tomasz Skorski
P2860
P304
P356
10.1128/MCB.23.21.7510-7524.2003
P407
P577
2003-11-01T00:00:00Z