about
Derivation and expansion using only small molecules of human neural progenitors for neurodegenerative disease modelingZfp296 is a novel, pluripotent-specific reprogramming factorInvestigating human disease using stem cell models.Discovery of inhibitors of microglial neurotoxicity acting through multiple mechanisms using a stem-cell-based phenotypic assay.Discovery of neuritogenic compound classes inspired by natural products.Leucine-Rich Repeat Kinase 2 Influences Fate Decision of Human Monocytes Differentiated from Induced Pluripotent Stem CellsHuman iPSC models of neuronal ceroid lipofuscinosis capture distinct effects of TPP1 and CLN3 mutations on the endocytic pathwayAstrocyte pathology in a human neural stem cell model of frontotemporal dementia caused by mutant TAU protein.iPS cell derived neuronal cells for drug discovery.Neuronal Dysfunction in iPSC-Derived Medium Spiny Neurons from Chorea-Acanthocytosis Patients Is Reversed by Src Kinase Inhibition and F-Actin Stabilization.Distinct developmental ground states of epiblast stem cell lines determine different pluripotency features.4-Aminopyridine Induced Activity Rescues Hypoexcitable Motor Neurons from Amyotrophic Lateral Sclerosis Patient-Derived Induced Pluripotent Stem Cells.Stepwise acquirement of hallmark neuropathology in FUS-ALS iPSC models depends on mutation type and neuronal aging.Primary Spinal OPC Culture System from Adult Zebrafish to Study Oligodendrocyte Differentiation In VitroRapid and efficient generation of oligodendrocytes from human induced pluripotent stem cells using transcription factors.HDAC6 inhibition reverses axonal transport defects in motor neurons derived from FUS-ALS patients.C9ORF72 interaction with cofilin modulates actin dynamics in motor neurons.Distinct Neurodegenerative Changes in an Induced Pluripotent Stem Cell Model of Frontotemporal Dementia Linked to Mutant TAU ProteinGenetic correction of a LRRK2 mutation in human iPSCs links parkinsonian neurodegeneration to ERK-dependent changes in gene expression.Bone morphogenetic proteins produced by cells within embryoid bodies inhibit ventral directed differentiation by Sonic Hedgehog.Impaired DNA damage response signaling by FUS-NLS mutations leads to neurodegeneration and FUS aggregate formation.Isogenic FUS-eGFP iPSC Reporter Lines Enable Quantification of FUS Stress Granule Pathology that Is Rescued by Drugs Inducing Autophagy.Discovery of a Novel Inhibitor of the Hedgehog Signaling Pathway through Cell-based Compound Discovery and Target Prediction.Origin-dependent neural cell identities in differentiated human iPSCs in vitro and after transplantation into the mouse brain.Dynarrestin, a Novel Inhibitor of Cytoplasmic Dynein.Neural induction intermediates exhibit distinct roles of Fgf signaling.RNA buffers the phase separation behavior of prion-like RNA binding proteins.Efficient differentiation of human embryonic stem cells into oligodendrocyte progenitors for application in a rat contusion model of spinal cord injury.Generation of iPSCs carrying a common LRRK2 risk allele for in vitro modeling of idiopathic Parkinson's disease.Highly Enantioselective Catalytic Synthesis of Neurite Growth-Promoting SecoyohimbanesModeling Parkinson's disease in midbrain-like organoidsDual Inhibition of GSK3β and CDK5 Protects the Cytoskeleton of Neurons from Neuroinflammatory-Mediated Degeneration In Vitro and In VivoAge-dependent neurodegeneration and organelle transport deficiencies in mutant TDP43 patient-derived neurons are independent of TDP43 aggregationPhenotypic Screening Using Mouse and Human Stem Cell-Based Models of Neuroinflammation and Gene Expression Analysis to Study Drug ResponsesA customizable microfluidic platform for medium-throughput modeling of neuromuscular circuitsDefective mitochondrial and lysosomal trafficking in chorea-acanthocytosis is independent of Src-kinase signalingViral Infections Exacerbate FUS-ALS Phenotypes in iPSC-Derived Spinal Neurons in a Virus Species-Specific MannerMuscleblind acts as a modifier of FUS toxicity by modulating stress granule dynamics and SMN localizationAltered calcium dynamics and glutamate receptor properties in iPSC-derived motor neurons from ALS patients with C9orf72, FUS, SOD1 or TDP43 mutationsFUS pathology in ALS is linked to alterations in multiple ALS-associated proteins and rescued by drugs stimulating autophagy
P50
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P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Jared Sterneckert
@ast
Jared Sterneckert
@en
Jared Sterneckert
@es
Jared Sterneckert
@nl
Jared Sterneckert
@sl
type
label
Jared Sterneckert
@ast
Jared Sterneckert
@en
Jared Sterneckert
@es
Jared Sterneckert
@nl
Jared Sterneckert
@sl
prefLabel
Jared Sterneckert
@ast
Jared Sterneckert
@en
Jared Sterneckert
@es
Jared Sterneckert
@nl
Jared Sterneckert
@sl
P106
P108
P21
P31
P496
0000-0002-7688-3124