A 21st century revisionist's view at a turning point in enzymology.
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Fundamental challenges in mechanistic enzymology: progress toward understanding the rate enhancements of enzymesA dynamic knockout reveals that conformational fluctuations influence the chemical step of enzyme catalysisComputer aided enzyme design and catalytic conceptsShedding light on protein folding, structural and functional dynamics by single molecule studiesEvolutionarily conserved linkage between enzyme fold, flexibility, and catalysisRevisiting the mechanism of the triosephosphate isomerase reaction: the role of the fully conserved glutamic acid 97 residueKeep on moving: discovering and perturbing the conformational dynamics of enzymesDynamically achieved active site precision in enzyme catalysisThe importance of ensemble averaging in enzyme kineticsEnzymatic transition states, transition-state analogs, dynamics, thermodynamics, and lifetimesAt the dawn of the 21st century: Is dynamics the missing link for understanding enzyme catalysis?Evidence for substrate preorganization in the peptidylglycine α-amidating monooxygenase reaction describing the contribution of ground state structure to hydrogen tunnelingCoupled motions direct electrons along human microsomal P450 ChainsCorrelating Calmodulin Landscapes with Chemical Catalysis in Neuronal Nitric Oxide Synthase using Time-Resolved FRET and a 5-Deazaflavin Thermodynamic TrapPerspective: Defining and quantifying the role of dynamics in enzyme catalysisFlexible backbone sampling methods to model and design protein alternative conformationsMining electron density for functionally relevant protein polysterism in crystal structures.The promoting vibration in human heart lactate dehydrogenase is a preferred vibrational channelCatalytic mechanism of α-phosphate attack in dUTPase is revealed by X-ray crystallographic snapshots of distinct intermediates, 31P-NMR spectroscopy and reaction path modelling.Electrostatic transition state stabilization rather than reactant destabilization provides the chemical basis for efficient chorismate mutase catalysis.Hydrogen tunneling in adenosylcobalamin-dependent glutamate mutase: evidence from intrinsic kinetic isotope effects measured by intramolecular competition.Hydrogen tunneling links protein dynamics to enzyme catalysisUpdate 1 of: Tunneling and dynamics in enzymatic hydride transfer.Importance of protein dynamics during enzymatic C-H bond cleavage catalysis.Examining the case for the effect of barrier compression on tunneling, vibrationally enhanced catalysis, catalytic entropy and related issuesTemperature dependence of protein motions in a thermophilic dihydrofolate reductase and its relationship to catalytic efficiencyExploring challenges in rational enzyme design by simulating the catalysis in artificial kemp eliminase.Taking Ockham's razor to enzyme dynamics and catalysis.Evidence that a 'dynamic knockout' in Escherichia coli dihydrofolate reductase does not affect the chemical step of catalysis.Choreographing an enzyme's dance.Evolutionary aspects of enzyme dynamicsChimeric β-lactamases: global conservation of parental function and fast time-scale dynamics with increased slow motionsChallenges and advances in validating enzyme design proposals: the case of kemp eliminase catalysisThe energy landscape of adenylate kinase during catalysis.Impaired protein conformational landscapes as revealed in anomalous Arrhenius prefactorsRole of dynamics in enzyme catalysis: substantial versus semantic controversies.Isotope effects as probes for enzyme catalyzed hydrogen-transfer reactions."Eppur si muove" (Yet it moves).Dynamics and dissipation in enzyme catalysisMultiple intermediates, diverse conformations, and cooperative conformational changes underlie the catalytic hydride transfer reaction of dihydrofolate reductase.
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P2860
A 21st century revisionist's view at a turning point in enzymology.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh
2009年學術文章
@zh-hant
name
A 21st century revisionist's view at a turning point in enzymology.
@en
A 21st century revisionist's view at a turning point in enzymology.
@nl
type
label
A 21st century revisionist's view at a turning point in enzymology.
@en
A 21st century revisionist's view at a turning point in enzymology.
@nl
prefLabel
A 21st century revisionist's view at a turning point in enzymology.
@en
A 21st century revisionist's view at a turning point in enzymology.
@nl
P356
P1476
A 21st century revisionist's view at a turning point in enzymology.
@en
P2093
Judith P Klinman
Zachary D Nagel
P2888
P304
P356
10.1038/NCHEMBIO.204
P577
2009-08-01T00:00:00Z
P6179
1008750119