about
FEM-based oxygen consumption and cell viability models for avascular pancreatic islets.A local glucose-and oxygen concentration-based insulin secretion model for pancreatic isletsOscillatory dynamics of Cdc42 GTPase in the control of polarized growth.Experimental evaluation and computational modeling of the effects of encapsulation on the time-profile of glucose-stimulated insulin release of pancreatic islets.Computer-assisted design of new drugs based on retrometabolic concepts.High-throughput screening for human galactokinase inhibitors.Effects of representative glucocorticoids on TNFα- and CD40L-induced NF-κB activation in sensor cellsSmall-molecule protein-protein interaction inhibitors: therapeutic potential in light of molecular size, chemical space, and ligand binding efficiency considerations.A three-parameter two-state model of receptor function that incorporates affinity, efficacy, and signal amplification.A simple, predictive, structure-based skin permeability model.Synthesis and pharmacological effects of new, N-substituted soft anticholinergics based on glycopyrrolate.Structure-metabolism relationships: steric effects and the enzymatic hydrolysis of carboxylic esters.Small-molecule modulators of the OX40-OX40 ligand co-stimulatory protein-protein interactionBarriers to remember: brain-targeting chemical delivery systems and Alzheimer's disease.Activity-limiting role of molecular size: size-dependency of maximum activity for P450 inhibition as revealed by qHTS data.Designing safer (soft) drugs by avoiding the formation of toxic and oxidative metabolites.Characterization of twenty-five ovarian tumour cell lines that phenocopy primary tumours.Biphasic decline of β-cell function with age in euglycemic nonobese diabetic mice parallels diabetes onsetPhosphorylation-dependent inhibition of Cdc42 GEF Gef1 by 14-3-3 protein Rad24 spatially regulates Cdc42 GTPase activity and oscillatory dynamics during cell morphogenesis.Resealable, optically accessible, PDMS-free fluidic platform for ex vivo interrogation of pancreatic islets.Ophthalmic drug design based on the metabolic activity of the eye: soft drugs and chemical delivery systems.Corticosteroid design for the treatment of asthma: structural insights and the therapeutic potential of soft corticosteroids.The promiscuous protein binding ability of erythrosine B studied by metachromasy (metachromasia).Vitamin D and androgen receptor-targeted therapy for triple-negative breast cancer.Recent advances in retrometabolic drug design (RMDD) and development.Recent advances in the design and development of soft drugs.Brain-Targeting Chemical Delivery Systems and Their Cyclodextrin-Based Formulations in Light of the Contributions of Marcus E. Brewster.Controlled Release of Dexamethasone from Organosilicone Constructs for Local Modulation of Inflammation in Islet Transplantation.Bilinear Model for the Size-Dependency of the CYP3A4 Inhibitory Activity of Structurally Diverse Compounds.Effective and specific inhibition of the CD40-CD154 costimulatory interaction by a naphthalenesulphonic acid derivative.Quantification of the islet product: presentation of a standardized current good manufacturing practices compliant system with minimal variability.Differences in the glucocorticoid to progesterone receptor selectivity of inhaled glucocorticoids.Drug targeting via retrometabolic approaches.Molecular organization of the complex between the muscarinic M3 receptor and the regulator of G protein signaling, Gbeta(5)-RGS7.Pharmacokinetics and delta1-cortienic acid excretion after intravenous administration of prednisolone and loteprednol etabonate in rats.Choice of immunosuppression influences cytomegalovirus DNAemia in cynomolgus monkey (Macaca fascicularis) islet allograft recipients.Small-molecule costimulatory blockade: organic dye inhibitors of the CD40-CD154 interaction.Attempts of ranking in a series of synthetic nonpsychotropic cannabinoids.In vitro and in vivo evaluations of dihydroquinoline- and dihydroisoquinoline-based targetor moieties for brain-specific chemical delivery systems.Organic dyes as small molecule protein-protein interaction inhibitors for the CD40-CD154 costimulatory interaction.
P50
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P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Peter Buchwald
@ast
Peter Buchwald
@en
Peter Buchwald
@es
Peter Buchwald
@nl
Peter Buchwald
@sl
type
label
Peter Buchwald
@ast
Peter Buchwald
@en
Peter Buchwald
@es
Peter Buchwald
@nl
Peter Buchwald
@sl
prefLabel
Peter Buchwald
@ast
Peter Buchwald
@en
Peter Buchwald
@es
Peter Buchwald
@nl
Peter Buchwald
@sl
P1053
G-4275-2010
P106
P1153
7003528374
P21
P31
P3829
P496
0000-0003-2732-8180