The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction.
about
Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination and degradation of WNK4Cul3-KLHL20 ubiquitin ligase: physiological functions, stress responses, and disease implicationsUbiquitylation and control of renal Na+ balance and blood pressureA molecular update on pseudohypoaldosteronism type IISmall-molecule WNK inhibition regulates cardiovascular and renal functionStructural and biochemical characterization of the KLHL3–WNK kinase interaction important in blood pressure regulationSystematic approaches to identify E3 ligase substratesDisease-causing mutations in KLHL3 impair its effect on WNK4 degradationMechanism and synergism in epithelial fluid and electrolyte secretion.A novel Ste20-related proline/alanine-rich kinase (SPAK)-independent pathway involving calcium-binding protein 39 (Cab39) and serine threonine kinase with no lysine member 4 (WNK4) in the activation of Na-K-Cl cotransporters.Regulation of with-no-lysine kinase signaling by Kelch-like proteins.Angiotensin II signaling via protein kinase C phosphorylates Kelch-like 3, preventing WNK4 degradationDistal convoluted tubuleA young child with pseudohypoaldosteronism type II by a mutation of Cullin 3.SPAK deficiency corrects pseudohypoaldosteronism II caused by WNK4 mutation.Generation of WNK1 knockout cell lines by CRISPR/Cas-mediated genome editing.Hyperkalemic hypertension-associated cullin 3 promotes WNK signaling by degrading KLHL3Ca(2+) is a Regulator of the WNK/OSR1/NKCC Pathway in a Human Salivary Gland Cell Line.Critical role of the SPAK protein kinase CCT domain in controlling blood pressureHypertension-causing Mutations in Cullin3 Protein Impair RhoA Protein Ubiquitination and Augment the Association with Substrate Adaptors.Stability of HIB-Cul3 E3 ligase adaptor HIB Is Regulated by Self-degradation and Availability of Its Substrates.Kelch-Like Protein 2 Mediates Angiotensin II-With No Lysine 3 Signaling in the Regulation of Vascular Tonus.Alternatively spliced proline-rich cassettes link WNK1 to aldosterone actionCharacterisation of the Cullin-3 mutation that causes a severe form of familial hypertension and hyperkalaemia.Towards the Development of Small-Molecule MO25 Binders as Potential Indirect SPAK/OSR1 Kinase Inhibitors.Cell-specific regulation of L-WNK1 by dietary K.Degradation by Cullin 3 and effect on WNK kinases suggest a role of KLHL2 in the pathogenesis of Familial Hyperkalemic HypertensionOsmotic stress induces the phosphorylation of WNK4 Ser575 via the p38MAPK-MK pathwayGeneration and analysis of knock-in mice carrying pseudohypoaldosteronism type II-causing mutations in the cullin 3 gene.The CUL3/KLHL3-WNK-SPAK/OSR1 pathway as a target for antihypertensive therapyCullin 3 as a novel target in diverse pathologiesHypertension: the missing WNKs.WNK1-related Familial Hyperkalemic Hypertension results from an increased expression of L-WNK1 specifically in the distal nephron.The emerging family of CULLIN3-RING ubiquitin ligases (CRL3s): cellular functions and disease implications.Multistep regulation of autophagy by WNK1Detection of mutations in KLHL3 and CUL3 in families with FHHt (familial hyperkalaemic hypertension or Gordon's syndrome).WNK signalling pathways in blood pressure regulationThe WNK-SPAK/OSR1 pathway: master regulator of cation-chloride cotransporters.Gordon Syndrome: a continuing story.Revisiting the NaCl cotransporter regulation by with-no-lysine kinases.
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P2860
The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年学术文章
@wuu
2013年学术文章
@zh-cn
2013年学术文章
@zh-hans
2013年学术文章
@zh-my
2013年学术文章
@zh-sg
2013年學術文章
@yue
2013年學術文章
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2013年學術文章
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name
The CUL3-KLHL3 E3 ligase compl ...... and WNK4 disrupt interaction.
@en
The CUL3-KLHL3 E3 ligase compl ...... and WNK4 disrupt interaction.
@nl
type
label
The CUL3-KLHL3 E3 ligase compl ...... and WNK4 disrupt interaction.
@en
The CUL3-KLHL3 E3 ligase compl ...... and WNK4 disrupt interaction.
@nl
prefLabel
The CUL3-KLHL3 E3 ligase compl ...... and WNK4 disrupt interaction.
@en
The CUL3-KLHL3 E3 ligase compl ...... and WNK4 disrupt interaction.
@nl
P2093
P2860
P50
P356
P1433
P1476
The CUL3-KLHL3 E3 ligase compl ...... and WNK4 disrupt interaction.
@en
P2093
Akihito Ohta
Axel Knebel
Clare Johnson
Frances-Rose Schumacher
Thomas J Macartney
P2860
P304
P356
10.1042/BJ20121903
P407
P577
2013-04-01T00:00:00Z