Analysis of Fyn function in hemostasis and alphaIIbbeta3-integrin signaling.
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The proline-rich tyrosine kinase Pyk2 regulates platelet integrin αIIbβ3 outside-in signaling.Lnk regulates integrin alphaIIbbeta3 outside-in signaling in mouse platelets, leading to stabilization of thrombus development in vivo.Endocytosis of flotillin-1 and flotillin-2 is regulated by Fyn kinase.Fyn is downstream of the HGF/MET signaling axis and affects cellular shape and tropism in PC3 cells.Cooperative integrin/ITAM signaling in platelets enhances thrombus formation in vitro and in vivo.Eptifibatide-induced thrombocytopenia and thrombosis in humans require FcgammaRIIa and the integrin beta3 cytoplasmic domain.Platelet Activation and Thrombus Formation over IgG Immune Complexes Requires Integrin αIIbβ3 and Lyn Kinase.ADAP interactions with talin and kindlin promote platelet integrin αIIbβ3 activation and stable fibrinogen binding.Structural and mechanical functions of integrins.Distinct and overlapping functional roles of Src family kinases in mouse platelets.Negative regulation of Gq-mediated pathways in platelets by G(12/13) pathways through Fyn kinase.The SH2 domain is crucial for function of Fyn in neuronal migration and cortical lamination.Tyrosine phosphorylated c-Cbl regulates platelet functional responses mediated by outside-in signalingThe Y's that bind: negative regulators of Src family kinase activity in platelets.Distinct roles for Rap1b protein in platelet secretion and integrin αIIbβ3 outside-in signalingConformational coupling of integrin and Thy-1 regulates Fyn priming and fibroblast mechanotransductionActivation and shedding of platelet glycoprotein IIb/IIIa under non-physiological shear stressSrc family tyrosine kinase Lyn mediates VWF/GPIb-IX-induced platelet activation via the cGMP signaling pathway.Identification of FcgammaRIIa as the ITAM-bearing receptor mediating alphaIIbbeta3 outside-in integrin signaling in human plateletsTwo distinct roles of mitogen-activated protein kinases in platelets and a novel Rac1-MAPK-dependent integrin outside-in retractile signaling pathwayAntithrombotic effects of targeting alphaIIbbeta3 signaling in platelets.Integrin signalling at a glance.Blood-based omic profiling supports female susceptibility to tobacco smoke-induced cardiovascular diseases.Fyn kinase inhibition as a novel therapy for Alzheimer's disease.Integrin bi-directional signaling across the plasma membrane.Inside-out, outside-in, and inside-outside-in: G protein signaling in integrin-mediated cell adhesion, spreading, and retraction.Src family kinases: at the forefront of platelet activationTargeting Fyn Kinase in Alzheimer's Disease.Maintenance of murine platelet homeostasis by the kinase Csk and the phosphatase CD148.Possible Molecular Targets of Novel Ruthenium Complexes in Antiplatelet Therapy.
P2860
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P2860
Analysis of Fyn function in hemostasis and alphaIIbbeta3-integrin signaling.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
Analysis of Fyn function in hemostasis and alphaIIbbeta3-integrin signaling.
@en
Analysis of Fyn function in hemostasis and alphaIIbbeta3-integrin signaling.
@nl
type
label
Analysis of Fyn function in hemostasis and alphaIIbbeta3-integrin signaling.
@en
Analysis of Fyn function in hemostasis and alphaIIbbeta3-integrin signaling.
@nl
prefLabel
Analysis of Fyn function in hemostasis and alphaIIbbeta3-integrin signaling.
@en
Analysis of Fyn function in hemostasis and alphaIIbbeta3-integrin signaling.
@nl
P2093
P2860
P356
P1476
Analysis of Fyn function in hemostasis and alphaIIbbeta3-integrin signaling.
@en
P2093
Dawn M Smith
Edward F Plow
Kumar B Reddy
P2860
P304
P356
10.1242/JCS.014076
P407
P577
2008-04-22T00:00:00Z