An actin-binding protein Girdin regulates the motility of breast cancer cells.
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STAT3 protein up-regulates Gα-interacting vesicle-associated protein (GIV)/Girdin expression, and GIV enhances STAT3 activation in a positive feedback loop during wound healing and tumor invasion/metastasisEphA2 mediates ligand-dependent inhibition and ligand-independent promotion of cell migration and invasion via a reciprocal regulatory loop with AktFunction and Regulation of Heterotrimeric G Proteins during ChemotaxisHeterotrimeric G proteins as emerging targets for network based therapy in cancer: End of a long futile campaign striking heads of a HydraInvolvement of Girdin in the determination of cell polarity during cell migrationSrc homology domain 2-containing protein-tyrosine phosphatase-1 (SHP-1) binds and dephosphorylates G(alpha)-interacting, vesicle-associated protein (GIV)/Girdin and attenuates the GIV-phosphatidylinositol 3-kinase (PI3K)-Akt signaling pathway.Metabolic characterization of invaded cells of the pancreatic cancer cell line, PANC-1.A structural determinant that renders G alpha(i) sensitive to activation by GIV/girdin is required to promote cell migration.A G{alpha}i-GIV molecular complex binds epidermal growth factor receptor and determines whether cells migrate or proliferate.Expression of GIV/Girdin, a metastasis-related protein, predicts patient survival in colon cancer.Structural basis for activation of trimeric Gi proteins by multiple growth factor receptors via GIV/Girdin.A GDI (AGS3) and a GEF (GIV) regulate autophagy by balancing G protein activity and growth factor signalsExpression of Girdin in primary hepatocellular carcinoma and its effect on cell proliferation and invasion.Multimodular biosensors reveal a novel platform for activation of G proteins by growth factor receptors.GIV/Girdin transmits signals from multiple receptors by triggering trimeric G protein activation.Therapeutic effects of cell-permeant peptides that activate G proteins downstream of growth factors.Cyclin-dependent kinase 5 activates guanine nucleotide exchange factor GIV/Girdin to orchestrate migration-proliferation dichotomyGirdin regulates the migration and invasion of glioma cells via the PI3K-Akt signaling pathway.Integrins activate trimeric G proteins via the nonreceptor protein GIV/GirdinF-actin rearrangement is regulated by mTORC2/Akt/Girdin in mouse fertilized eggs.Akt1 mediates prostate cancer cell microinvasion and chemotaxis to metastatic stimuli via integrin β₃ affinity modulation.Interleukin-17 promotes angiogenesis by stimulating VEGF production of cancer cells via the STAT3/GIV signaling pathway in non-small-cell lung cancer.The α-subunit of the trimeric GTPase Go2 regulates axonal growthConstitutive activation of STAT3 in breast cancer cells: A review.CCDC88A mutations cause PEHO-like syndrome in humans and mouseGirdin expression in cervical carcinoma and its role in the malignant properties of HeLa cells.Protein kinase C-theta (PKCθ) phosphorylates and inhibits the guanine exchange factor, GIV/GirdinClinical implications of Girdin and PI3K protein expression in breast cancer.Oncogenic cooperation between PI3K/Akt signaling and transcription factor Runx2 promotes the invasive properties of metastatic breast cancer cellsGirdin (GIV) Expression as a Prognostic Marker of Recurrence in Mismatch Repair-Proficient Stage II Colon CancerGIV is a nonreceptor GEF for G alpha i with a unique motif that regulates Akt signaling.Silencing of D4-GDI inhibits growth and invasive behavior in MDA-MB-231 cells by activation of Rac-dependent p38 and JNK signalingClinical significance of Girdin expression detected by immunohistochemistry in non-small cell lung cancer.CCDC88A, a prognostic factor for human pancreatic cancers, promotes the motility and invasiveness of pancreatic cancer cellsExpression and clinical significance of girdin in gastric cancer.Distinct biological roles for the akt family in mammary tumor progressionGirdin is an intrinsic regulator of neuroblast chain migration in the rostral migratory stream of the postnatal brain.The untapped potential of tyrosine-based G protein signaling.Heterotrimeric G protein signaling via GIV/Girdin: Breaking the rules of engagement, space, and time.Collective invasion of cancer: Perspectives from pathology and development.
P2860
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P2860
An actin-binding protein Girdin regulates the motility of breast cancer cells.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
An actin-binding protein Girdin regulates the motility of breast cancer cells.
@en
type
label
An actin-binding protein Girdin regulates the motility of breast cancer cells.
@en
prefLabel
An actin-binding protein Girdin regulates the motility of breast cancer cells.
@en
P2093
P1433
P1476
An actin-binding protein Girdin regulates the motility of breast cancer cells.
@en
P2093
Atsushi Enomoto
Maki Ishida
Masahide Takahashi
Mayumi Jijiwa
Naoya Asai
Ping Jiang
Taisaku Hasegawa
Takuya Kato
Tomoko Sato
Yoshiki Murakumo
P304
P356
10.1158/0008-5472.CAN-07-5111
P407
P577
2008-03-01T00:00:00Z