A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain.
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Requirement of atypical protein kinase clambda for insulin stimulation of glucose uptake but not for Akt activation in 3T3-L1 adipocytesPHR1 encodes an abundant, pleckstrin homology domain-containing integral membrane protein in the photoreceptor outer segmentsPhosphorylation of the PTEN tail regulates protein stability and functionUV induces phosphorylation of protein kinase B (Akt) at Ser-473 and Thr-308 in mouse epidermal C1 41 cells through hydrogen peroxideAssociation of the insulin receptor with phospholipase C-gamma (PLCgamma) in 3T3-L1 adipocytes suggests a role for PLCgamma in metabolic signaling by insulinFBXL2- and PTPL1-mediated degradation of p110-free p85β regulatory subunit controls the PI(3)K signalling cascadeActivation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B alphaRole of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1Signal-dependent membrane targeting by pleckstrin homology (PH) domainsIdentification and analysis of PH domain-containing targets of phosphatidylinositol 3-kinase using a novel in vivo assay in yeast.The Phox homology (PX) domain, a new player in phosphoinositide signallingA PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegansModulation of prostate cancer genetic risk by omega-3 and omega-6 fatty acidsCytokine-stimulated T cells induce macrophage IL-10 production dependent on phosphatidylinositol 3-kinase and p70S6K: implications for rheumatoid arthritisA transforming mutation in the pleckstrin homology domain of AKT1 in cancerThe solution structure of the pleckstrin homology domain of human SOS1. A possible structural role for the sequential association of diffuse B cell lymphoma and pleckstrin homology domainsThe solution structure and dynamics of the pleckstrin homology domain of G protein-coupled receptor kinase 2 (beta-adrenergic receptor kinase 1). A binding partner of Gbetagamma subunitsSCOP, a novel gene product expressed in a circadian manner in rat suprachiasmatic nucleusSulindac and its metabolites inhibit invasion of glioblastoma cells via down-regulation of Akt/PKB and MMP-2Heregulin-dependent activation of phosphoinositide 3-kinase and Akt via the ErbB2/ErbB3 co-receptorProtein kinase B is regulated in platelets by the collagen receptor glycoprotein VIErythropoietin induces the tyrosine phosphorylation of insulin receptor substrate-2. An alternate pathway for erythropoietin-induced phosphatidylinositol 3-kinase activationMitogenic activation, phosphorylation, and nuclear translocation of protein kinase BbetaGrowth factors and insulin stimulate tyrosine phosphorylation of the 51C/SHIP2 proteinLigands of CD4 inhibit the association of phospholipase Cgamma1 with phosphoinositide 3 kinase in T cells: regulation of this association by the phosphoinositide 3 kinase activityAn SH2-domain-containing kinase negatively regulates the phosphatidylinositol-3 kinase pathwayPhosphoinositide 3-kinase-gamma induces Xenopus oocyte maturation via lipid kinase activityExpression cloning of protein targets for 3-phosphorylated phosphoinositidesInterleukin-4 alters early phagosome phenotype by modulating class I PI3K dependent lipid remodeling and protein recruitmentRequirement for Akt (protein kinase B) in insulin-induced activation of glycogen synthase and phosphorylation of 4E-BP1 (PHAS-1)Requirement for activation of the serine-threonine kinase Akt (protein kinase B) in insulin stimulation of protein synthesis but not of glucose transportPPAR-gamma inhibits ANG II-induced cell growth via SHIP2 and 4E-BP1Thrombin induces expression of FGF-2 via activation of PI3K-Akt-Fra-1 signaling axis leading to DNA synthesis and motility in vascular smooth muscle cellsPrimary structure, tissue distribution, and expression of mouse phosphoinositide-dependent protein kinase-1, a protein kinase that phosphorylates and activates protein kinase CzetaThe src homology domain 2-containing inositol phosphatase SHIP forms a ternary complex with Shc and Grb2 in antigen receptor-stimulated B lymphocytesA novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signalingCaenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factorTyrosine 1101 of Tie2 is the major site of association of p85 and is required for activation of phosphatidylinositol 3-kinase and AktType I phosphatidylinositol-4-phosphate 5-kinases synthesize the novel lipids phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 5-phosphateNew insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway
P2860
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P2860
A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
A specific product of phosphat ...... ts pleckstrin homology domain.
@en
type
label
A specific product of phosphat ...... ts pleckstrin homology domain.
@en
prefLabel
A specific product of phosphat ...... ts pleckstrin homology domain.
@en
P2093
P2860
P356
P1476
A specific product of phosphat ...... its pleckstrin homology domain
@en
P2093
L T Williams
W M Kavanaugh
P2860
P304
P356
10.1128/MCB.17.1.338
P407
P50
P577
1997-01-01T00:00:00Z