E2A deficiency leads to abnormalities in alphabeta T-cell development and to rapid development of T-cell lymphomas. - Wikidata - awgldk - TriplyDB

E2A deficiency leads to abnormalities in alphabeta T-cell development and to rapid development of T-cell lymphomas.

E2A deficiency leads to abnormalities in alphabeta T-cell development and to rapid development of T-cell lymphomas.

http://www.wikidata.org/entity/Q40023076

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Cardiovascular basic helix loop helix factor 1, a novel transcriptional repressor expressed preferentially in the developing and adult cardiovascular system Functions of E2A-HEB heterodimers in T-cell development revealed by a dominant negative mutation of HEB Promotion of cell cycle progression by basic helix-loop-helix E2A NKX3.1 is a direct TAL1 target gene that mediates proliferation of TAL1-expressing human T cell acute lymphoblastic leukemia Characterization of ABF-1, a novel basic helix-loop-helix transcription factor expressed in activated B lymphocytes.HEB and E2A function as SMAD/FOXH1 cofactors mSin3A regulates murine erythroleukemia cell differentiation through association with the TAL1 (or SCL) transcription factor Helix-loop-helix proteins: regulators of transcription in eucaryotic organisms OLIG2 (BHLHB1), a bHLH transcription factor, contributes to leukemogenesis in concert with LMO1 HEB in the spotlight: Transcriptional regulation of T-cell specification, commitment, and developmental plasticity Deciphering the transcriptional switches of innate lymphoid cell programming: the right factors at the right time Factors and networks that underpin early hematopoiesis Characterization of the mUBC9-binding sites required for E2A protein degradation Regulation of pT alpha gene expression by a dosage of E2A, HEB, and SCL Gradient of E2A activity in B-cell development.Lymphoid-specific expression of the Id3 gene in hematopoietic cells. Selective antagonism of E2A basic helix-loop-helix protein associated with Id3-induced differentiation of erythroleukemia cells Extinction of expression of the genes encoding haematopoietic cell-restricted transcription factors in T-lymphoma x fibroblast cell hybrids Disordered T-cell development and T-cell malignancies in SCL LMO1 double-transgenic mice: parallels with E2A-deficient mice The DNA binding activity of TAL-1 is not required to induce leukemia/lymphoma in mice E proteins are required to activate germline transcription of the TCR Vbeta8.2 gene Decoding hematopoietic specificity in the helix-loop-helix domain of the transcription factor SCL/Tal-1 Regulation of the helix-loop-helix proteins, E2A and Id3, by the Ras-ERK MAPK cascade.Tumor suppressors BTG1 and IKZF1 cooperate during mouse leukemia development and increase relapse risk in B-cell precursor acute lymphoblastic leukemia patients.Disrupted differentiation and oncogenic transformation of lymphoid progenitors in E2A-HLF transgenic mice Control of CD4 gene expression: connecting signals to outcomes in T cell development.Transcriptional regulation of lymphocyte lineage commitment.The stromal proteinase MMP3/stromelysin-1 promotes mammary carcinogenesis.The oncogenic T cell LIM-protein Lmo2 forms part of a DNA-binding complex specifically in immature T cells Isolation and characterization of the activated B-cell factor 1 homolog in Caenorhabditis elegans.Polycomb repressor complex 2 regulates HOXA9 and HOXA10, activating ID2 in NK/T-cell lines.A global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates B cell fate.Role for homodimerization in growth deregulation by E2a fusion proteins.Disruption of pre-TCR expression accelerates lymphomagenesis in E2A-deficient mice ID'ing innate and innate-like lymphoid cells Intertwining proteins in thymocyte development and cancer.Enhanced Notch activation is advantageous but not essential for T cell lymphomagenesis in Id1 transgenic mice From the cradle to the grave: activities of GATA-3 throughout T-cell development and differentiation.Transcriptional control of invariant NKT cell development.Transcriptional control of t lymphocyte differentiation.E proteins and the regulation of early lymphocyte development

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P2860

E2A deficiency leads to abnormalities in alphabeta T-cell development and to rapid development of T-cell lymphomas.

http://www.wikidata.org/entity/Q40023076

description

1997 nî lūn-bûn

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1997年の論文

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1997年論文

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1997年論文

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1997年論文

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1997年論文

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1997年論文

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1997年论文

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1997年论文

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1997年论文

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name

E2A deficiency leads to abnorm ...... velopment of T-cell lymphomas.

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type

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E2A deficiency leads to abnorm ...... velopment of T-cell lymphomas.

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E2A deficiency leads to abnorm ...... velopment of T-cell lymphomas.

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P1433

Molecular and Cellular Biology

P1476

E2A deficiency leads to abnorm ...... velopment of T-cell lymphomas.

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P2093

B Huey

http://www.w3.org/2001/XMLSchema#string

C Murre

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D Pinkel

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E C Robanus Maandag

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G Bain

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H P te Riele

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I Engel

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J Chun

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J R Voland

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L L Sharp

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P2860

A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins

Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence

Two distinct transcription factors that bind the immunoglobulin enhancer microE5/kappa 2 motif

TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia

The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix-loop-helix protein

The gene SCL is expressed during early hematopoiesis and encodes a differentiation-related DNA-binding motif

Helix-loop-helix proteins LYL1 and E2a form heterodimeric complexes with distinctive DNA-binding properties in hematolymphoid cells

B-cell-specific DNA binding by an E47 homodimer

E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements

Two distinct mechanisms for the SCL gene activation in the t(1;14) translocation of T-cell leukemias

P304

4782-4791

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10.1128/MCB.17.8.4782

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8

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17

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9234734

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232330

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