Biogenesis of gamma-secretase early in the secretory pathway.
about
Phenylbutyric acid rescues endoplasmic reticulum stress-induced suppression of APP proteolysis and prevents apoptosis in neuronal cellsSec24b selectively sorts Vangl2 to regulate planar cell polarity during neural tube closureSEC24A deficiency lowers plasma cholesterol through reduced PCSK9 secretion.The cleavage products of amyloid-beta precursor protein are sorted to distinct carrier vesicles that are independently transported within neurites.ER retention is imposed by COPII protein sorting and attenuated by 4-phenylbutyrate.Proteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process.Charting the secretory pathway in a simple eukaryote.Mutation analysis of the presenilin 1 N-terminal domain reveals a broad spectrum of gamma-secretase activity toward amyloid precursor protein and other substrates.The PERK pathway independently triggers apoptosis and a Rac1/Slpr/JNK/Dilp8 signaling favoring tissue homeostasis in a chronic ER stress Drosophila modelAnks1a regulates COPII-mediated anterograde transport of receptor tyrosine kinases critical for tumorigenesisLINGO-1 promotes lysosomal degradation of amyloid-β protein precursor.The [corrected] SEC23-SEC31 [corrected] interface plays critical role for export of procollagen from the endoplasmic reticulumCOPII-Dependent ER Export: A Critical Component of Insulin Biogenesis and β-Cell ER Homeostasis.A triple arg motif mediates α(2B)-adrenergic receptor interaction with Sec24C/D and export.Lysosomal calcium homeostasis defects, not proton pump defects, cause endo-lysosomal dysfunction in PSEN-deficient cells.Amyloid precursor protein (APP) traffics from the cell surface via endosomes for amyloid β (Aβ) production in the trans-Golgi networkRetention in endoplasmic reticulum 1 (RER1) modulates amyloid-β (Aβ) production by altering trafficking of γ-secretase and amyloid precursor protein (APP).Toward structural elucidation of the gamma-secretase complex.Sequence analyses of presenilin mutations linked to familial Alzheimer's disease.Neuronal protein trafficking associated with Alzheimer disease: from APP and BACE1 to glutamate receptorsSingle chain variable fragment against nicastrin inhibits the gamma-secretase activity.Molecular mechanism of intramembrane proteolysis by γ-secretase.Mammalian TRAPPIII Complex positively modulates the recruitment of Sec13/31 onto COPII vesicles.Neurodegeneration-associated mutant TREM2 proteins abortively cycle between the ER and ER-Golgi intermediate compartment.Small molecules intercept Notch signaling and the early secretory pathway.Phenylbutyric acid reduces amyloid plaques and rescues cognitive behavior in AD transgenic mice.Dimeric sorting code for concentrative cargo selection by the COPII coat.
P2860
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P2860
Biogenesis of gamma-secretase early in the secretory pathway.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Biogenesis of gamma-secretase early in the secretory pathway.
@en
type
label
Biogenesis of gamma-secretase early in the secretory pathway.
@en
prefLabel
Biogenesis of gamma-secretase early in the secretory pathway.
@en
P2093
P2860
P356
P1476
Biogenesis of gamma-secretase early in the secretory pathway.
@en
P2093
Bertrand Kleizen
Gopal Thinakaran
Regina Choy
Sangram S Sisodia
P2860
P304
P356
10.1083/JCB.200709012
P407
P577
2007-12-01T00:00:00Z