Akt inhibitor shows anticancer and radiosensitizing effects in malignant glioma cells by inducing autophagy.
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A combination of indol-3-carbinol and genistein synergistically induces apoptosis in human colon cancer HT-29 cells by inhibiting Akt phosphorylation and progression of autophagyTherapeutic interactions of autophagy with radiation and temozolomide in glioblastoma: evidence and issues to resolveTherapeutic Implications for Overcoming Radiation Resistance in Cancer TherapyAutophagy and radiosensitization in cancerEnhancement of autophagy is a potential modality for tumors refractory to radiotherapy.Targeting the PI3K/mTOR axis, alone and in combination with autophagy blockade, for the treatment of malignant peripheral nerve sheath tumorsPolycomb group gene BMI1 controls invasion of medulloblastoma cells and inhibits BMP-regulated cell adhesion.Autophagy: cerebral home cooking.Ablation of Akt2 induces autophagy through cell cycle arrest, the downregulation of p70S6K, and the deregulation of mitochondria in MDA-MB231 cells.Increased drug resistance is associated with reduced glucose levels and an enhanced glycolysis phenotype.Cytotoxic autophagy in cancer therapy.Hypoxia increases the expression of stem-cell markers and promotes clonogenicity in glioblastoma neurospheresEnhancement of radiosensitivity in human glioblastoma cells by the DNA N-mustard alkylating agent BO-1051 through augmented and sustained DNA damage response.A novel oncolytic herpes simplex virus that synergizes with phosphoinositide 3-kinase/Akt pathway inhibitors to target glioblastoma stem cells.Phenylpropanoids in radioregulation: double edged sword.Sorting and identification of side population cells in the human cervical cancer cell line HeLa.eEF-2 kinase dictates cross-talk between autophagy and apoptosis induced by Akt Inhibition, thereby modulating cytotoxicity of novel Akt inhibitor MK-2206.Radiosensitization of Primary Human Glioblastoma Stem-like Cells with Low-Dose AKT Inhibition.Increased autophagy and apoptosis contribute to muscle atrophy in a myotonic dystrophy type 1 Drosophila model.Puquitinib mesylate (XC-302) induces autophagy via inhibiting the PI3K/AKT/mTOR signaling pathway in nasopharyngeal cancer cellsA combined DNA-affinic molecule and N-mustard alkylating agent has an anti-cancer effect and induces autophagy in oral cancer cells.Dual Targeting of Akt and mTORC1 Impairs Repair of DNA Double-Strand Breaks and Increases Radiation Sensitivity of Human Tumor Cells.Rapamycin-induced autophagy sensitizes A549 cells to radiation associated with DNA damage repair inhibition.The convergence of radiation and immunogenic cell death signaling pathways.Autophagy is associated with chemoresistance in neuroblastoma.Autophagy and lysosomal related protein expression patterns in human glioblastoma.Autophagy inhibition plays the synergetic killing roles with radiation in the multi-drug resistant SKVCR ovarian cancer cells.Ophiopogonin B-induced autophagy in non-small cell lung cancer cells via inhibition of the PI3K/Akt signaling pathway.TAK1 regulates autophagic cell death by suppressing the phosphorylation of p70 S6 kinase 1.Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents.TLR9-ERK-mTOR signaling is critical for autophagic cell death induced by CpG oligodeoxynucleotide 107 combined with irradiation in glioma cellsMarchantin M: a novel inhibitor of proteasome induces autophagic cell death in prostate cancer cells.Therapeutic targeting of autophagy in disease: biology and pharmacology.Brain cancer stem cells display preferential sensitivity to Akt inhibition.Targeting autophagic pathways for cancer drug discoveryAutophagy in tumour suppression and promotion.Targeting autophagy during cancer therapy to improve clinical outcomes.Impact of Autophagy on Chemotherapy and Radiotherapy Mediated Tumor Cytotoxicity: "To Live or not to Live".Silencing BMI1 radiosensitizes human breast cancer cells by inducing DNA damage and autophagy.Role of autophagy in apoptotic regulation by Akt in pancreatic cancer
P2860
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P2860
Akt inhibitor shows anticancer and radiosensitizing effects in malignant glioma cells by inducing autophagy.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Akt inhibitor shows anticancer ...... a cells by inducing autophagy.
@en
type
label
Akt inhibitor shows anticancer ...... a cells by inducing autophagy.
@en
prefLabel
Akt inhibitor shows anticancer ...... a cells by inducing autophagy.
@en
P2093
P1476
Akt inhibitor shows anticancer ...... a cells by inducing autophagy.
@en
P2093
Eiji Iwado
Gordon B Mills
Keishi Fujiwara
Raymond Sawaya
Seiji Kondo
Yasuko Kondo
P304
P577
2007-10-01T00:00:00Z