Muscleblind-like 1 interacts with RNA hairpins in splicing target and pathogenic RNAs.
about
ZNF9 activation of IRES-mediated translation of the human ODC mRNA is decreased in myotonic dystrophy type 2MBNL and CELF proteins regulate alternative splicing of the skeletal muscle chloride channel CLCN1Role of RNA structure in regulating pre-mRNA splicingHITS-CLIP yields genome-wide insights into brain alternative RNA processingStructural studies of CNG repeatsMechanisms of RNA-induced toxicity in CAG repeat disordersRNA protein interaction in neuronsSolution structure of the RNA binding domain in the human muscleblind-like protein 2Structural insights into CUG repeats containing the 'stretched U-U wobble': implications for myotonic dystrophyAtomic resolution structure of CAG RNA repeats: structural insights and implications for the trinucleotide repeat expansion diseasesCrystal structures of CGG RNA repeats with implications for fragile X-associated tremor ataxia syndromeCrystallographic characterization of CCG repeatsRNA-mediated pathogenic mechanisms in polyglutamine diseases and amyotrophic lateral sclerosisIdentification of variants in MBNL1 in patients with a myotonic dystrophy-like phenotypeMBNL1 and PTB cooperate to repress splicing of Tpm1 exon 3RNA and diseaseCysteine and histidine shuffling: mixing and matching cysteine and histidine residues in zinc finger proteins to afford different folds and function.The RNA-binding protein Staufen1 is increased in DM1 skeletal muscle and promotes alternative pre-mRNA splicingNew function for the RNA helicase p68/DDX5 as a modifier of MBNL1 activity on expanded CUG repeatsTrinucleotide repeats: a structural perspectiveSingle-molecule study of the CUG repeat-MBNL1 interaction and its inhibition by small molecules.Examining the interactions of the splicing factor MBNL1 with target RNA sequences via a label-free, multiplex methodIdentification of genes in toxicity pathways of trinucleotide-repeat RNA in C. elegans.Computational investigation of RNA CUG repeats responsible for myotonic dystrophy 1Mechanistic determinants of MBNL activityDrosophila muscleblind is involved in troponin T alternative splicing and apoptosisRNA gain-of-function in spinocerebellar ataxia type 8.Autoregulation of MBNL1 function by exon 1 exclusion from MBNL1 transcript.Aberrant alternative splicing and extracellular matrix gene expression in mouse models of myotonic dystrophy.MBNL1 binds GC motifs embedded in pyrimidines to regulate alternative splicing.Myotonic dystrophies 1 and 2: complex diseases with complex mechanisms.The four Zn fingers of MBNL1 provide a flexible platform for recognition of its RNA binding elements.Splicing biomarkers of disease severity in myotonic dystrophyMuscleblind-like 1 (Mbnl1) promotes insulin receptor exon 11 inclusion via binding to a downstream evolutionarily conserved intronic enhancer.Two high-throughput screening assays for aberrant RNA-protein interactions in myotonic dystrophy type 1.Drosophila muscleblind codes for proteins with one and two tandem zinc finger motifsRNA-binding protein Muscleblind-like 3 (MBNL3) disrupts myocyte enhancer factor 2 (Mef2) {beta}-exon splicing.RNA-protein interactions in unstable microsatellite diseases.MBNL proteins and their target RNAs, interaction and splicing regulation.Ubiquitous expression of CUG or CAG trinucleotide repeat RNA causes common morphological defects in a Drosophila model of RNA-mediated pathology
P2860
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P2860
Muscleblind-like 1 interacts with RNA hairpins in splicing target and pathogenic RNAs.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Muscleblind-like 1 interacts with RNA hairpins in splicing target and pathogenic RNAs.
@en
type
label
Muscleblind-like 1 interacts with RNA hairpins in splicing target and pathogenic RNAs.
@en
prefLabel
Muscleblind-like 1 interacts with RNA hairpins in splicing target and pathogenic RNAs.
@en
P2093
P2860
P356
P1476
Muscleblind-like 1 interacts with RNA hairpins in splicing target and pathogenic RNAs.
@en
P2093
Charles A Thornton
Jack D Griffith
Krzysztof Sobczak
Myrna G Stenberg
Sarah A Compton
P2860
P304
P356
10.1093/NAR/GKM601
P577
2007-08-15T00:00:00Z