Defective TGF-beta signaling sensitizes human cancer cells to rapamycin.
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TGF-β - an excellent servant but a bad masterComplexities of TGF-β targeted cancer therapy.Halofuginone Synergistically Enhances Anti-Proliferation of Rapamycin in T Cells and Reduces Cytotoxicity of Cyclosporine in Cultured Renal Tubular Epithelial CellsRole of mTOR, Bad, and Survivin in RasGAP Fragment N-Mediated Cell ProtectionRegulation of G1 Cell Cycle Progression: Distinguishing the Restriction Point from a Nutrient-Sensing Cell Growth Checkpoint(s)Transforming growth factor-β-induced lncRNA-Smad7 inhibits apoptosis of mouse breast cancer JygMC(A) cells.Phospholipase D mediates nutrient input to mammalian target of rapamycin complex 1 (mTORC1).Rapamycin-induced G1 cell cycle arrest employs both TGF-β and Rb pathwaysHigh-dose rapamycin induces apoptosis in human cancer cells by dissociating mTOR complex 1 and suppressing phosphorylation of 4E-BP1.Targeted cancer therapy--are the days of systemic chemotherapy numbered?Apoptotic effects of high-dose rapamycin occur in S-phase of the cell cycle.Integration of transforming growth factor beta and RAS signaling silences a RAB5 guanine nucleotide exchange factor and enhances growth factor-directed cell migration.The Enigma of Rapamycin Dosage.5-Aminoimidazole-4-carboxamide-1-β-4-ribofuranoside (AICAR) enhances the efficacy of rapamycin in human cancer cells.Inhibition of S6 kinase suppresses the apoptotic effect of eIF4E ablation by inducing TGF-β-dependent G1 cell cycle arrest.Phosphatidic acid and lipid-sensing by mTORA gene signature-based approach identifies mTOR as a regulator of p73.Regulation of mTORC1 and mTORC2 complex assembly by phosphatidic acid: competition with rapamycin.Breast cancer by proxy: can the microenvironment be both the cause and consequence?Phosphatidic acid signaling to mTOR: signals for the survival of human cancer cells.Honokiol suppresses survival signals mediated by Ras-dependent phospholipase D activity in human cancer cells.Role of TGF-β in breast cancer bone metastases.Perspectives of TGF-β inhibition in pancreatic and hepatocellular carcinomas.Mutant ras elevates dependence on serum lipids and creates a synthetic lethality for rapamycinTGF-β in the Bone Microenvironment: Role in Breast Cancer Metastases.The role of TGF-β in bone metastasis: novel therapeutic perspectives.Differential dependence of hypoxia-inducible factors 1 alpha and 2 alpha on mTORC1 and mTORC2.Role of HHV-8 and mTOR pathway in post-transplant Kaposi sarcoma staging.Lipid sensing by mTOR complexes via de novo synthesis of phosphatidic acid.
P2860
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P2860
Defective TGF-beta signaling sensitizes human cancer cells to rapamycin.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Defective TGF-beta signaling sensitizes human cancer cells to rapamycin.
@en
type
label
Defective TGF-beta signaling sensitizes human cancer cells to rapamycin.
@en
prefLabel
Defective TGF-beta signaling sensitizes human cancer cells to rapamycin.
@en
P2093
P2860
P356
P1433
P1476
Defective TGF-beta signaling sensitizes human cancer cells to rapamycin.
@en
P2093
P2860
P2888
P304
P356
10.1038/SJ.ONC.1210721
P407
P577
2007-08-13T00:00:00Z
P5875
P6179
1042816782