Loss of PTEN selectively desensitizes upstream IGF1 and insulin signaling.
about
PTEN is a protein tyrosine phosphatase for IRS1A limited role for PI(3,4,5)P3 regulation in controlling skeletal muscle mass in response to resistance exercise.Developmental stage-specific interplay of GATA1 and IGF signaling in fetal megakaryopoiesis and leukemogenesisIgf2 ligand dependency of Pten(+/-) developmental and tumour phenotypes in the mouseIrs2 inactivation suppresses tumor progression in Pten+/- mice.PTEN regulates IGF-1R-mediated therapy resistance in melanoma.Down-regulation of phosphatase and tensin homolog by hepatitis C virus core 3a in hepatocytes triggers the formation of large lipid droplets.Suppression of cellular proliferation and invasion by the concerted lipid and protein phosphatase activities of PTEN.Phosphatase and tensin homolog (PTEN) regulates hepatic lipogenesis, microsomal triglyceride transfer protein, and the secretion of apolipoprotein B-containing lipoproteins.PTEN in liver diseases and cancerMutation of the Rb1 pathway leads to overexpression of mTor, constitutive phosphorylation of Akt on serine 473, resistance to anoikis, and a block in c-Raf activation.PQ401, an IGF-1R inhibitor, induces apoptosis and inhibits growth, proliferation and migration of glioma cells.
P2860
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P2860
Loss of PTEN selectively desensitizes upstream IGF1 and insulin signaling.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Loss of PTEN selectively desensitizes upstream IGF1 and insulin signaling.
@en
type
label
Loss of PTEN selectively desensitizes upstream IGF1 and insulin signaling.
@en
prefLabel
Loss of PTEN selectively desensitizes upstream IGF1 and insulin signaling.
@en
P2093
P2860
P356
P1433
P1476
Loss of PTEN selectively desensitizes upstream IGF1 and insulin signaling
@en
P2093
P2860
P2888
P304
P356
10.1038/SJ.ONC.1210520
P407
P577
2007-05-07T00:00:00Z
P5875
P6179
1038071429