Discovery of dual inhibitors of the immune cell PI3Ks p110delta and p110gamma: a prototype for new anti-inflammatory drugs.
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A selective inhibitor reveals PI3Kγ dependence of T(H)17 cell differentiationPhenotypic screening of the ToxCast chemical library to classify toxic and therapeutic mechanismsBuilding predictive models for mechanism-of-action classification from phenotypic assay data sets.Elucidating mechanisms of toxicity using phenotypic data from primary human cell systems--a chemical biology approach for thrombosis-related side effects.PI3Kγ drives priming and survival of autoreactive CD4(+) T cells during experimental autoimmune encephalomyelitis.The anti-atherogenic cytokine interleukin-33 inhibits the expression of a disintegrin and metalloproteinase with thrombospondin motifs-1, -4 and -5 in human macrophages: Requirement of extracellular signal-regulated kinase, c-Jun N-terminal kinase aCritical role for phosphoinositide 3-kinase gamma in parasite invasion and disease progression of cutaneous leishmaniasis.Two birds with one stone: dual p110δ and p110γ inhibitionThe novel therapeutic effect of phosphoinositide 3-kinase-γ inhibitor AS605240 in autoimmune diabetes.The Therapeutic Potential for PI3K Inhibitors in Autoimmune Rheumatic DiseasesDifferent phosphoinositide 3-kinase isoforms mediate carrageenan nociception and inflammationA pharmacological model reveals biased dependency on PI3K isoforms for tumor cell growth.PI3K inhibitors in inflammation, autoimmunity and cancer.Human target validation of phosphoinositide 3-kinase (PI3K)β: effects on platelets and insulin sensitivity, using AZD6482 a novel PI3Kβ inhibitor.Discovery of a Series of 5,11-Dihydro-6H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6-ones as Selective PI3K-δ/γ InhibitorsSelective inhibitors of phosphoinositide 3-kinase delta: modulators of B-cell function with potential for treating autoimmune inflammatory diseases and B-cell malignancies.Regulation of T cell alloimmunity by PI3Kγ and PI3Kδ.Harnessing the Electric Spark of Life to Cure Skin WoundsNew blood: Creative funding of disease-specific research.Discovery of Pyrazolopyrimidine Derivatives as Novel Dual Inhibitors of BTK and PI3Kδ.Blocking pathogen entry into the cell: the future of infectious disease treatment and control?Comprehensive analysis of T cell leukemia signals reveals heterogeneity in the PI3 kinase-Akt pathway and limitations of PI3 kinase inhibitors as monotherapy.
P2860
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P2860
Discovery of dual inhibitors of the immune cell PI3Ks p110delta and p110gamma: a prototype for new anti-inflammatory drugs.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
Discovery of dual inhibitors o ...... r new anti-inflammatory drugs.
@en
type
label
Discovery of dual inhibitors o ...... r new anti-inflammatory drugs.
@en
prefLabel
Discovery of dual inhibitors o ...... r new anti-inflammatory drugs.
@en
P2093
P2860
P1476
Discovery of dual inhibitors o ...... r new anti-inflammatory drugs.
@en
P2093
Benjamin T Houseman
Brian Aizenstein
Eric J Kunkel
Kevan M Shokat
Olusegun Williams
Randy Hoffman
P2860
P304
P356
10.1016/J.CHEMBIOL.2010.01.010
P577
2010-02-01T00:00:00Z