Systematic dissection of regulatory motifs in 2000 predicted human enhancers using a massively parallel reporter assay. - Wikidata - awgldk - TriplyDB

Systematic dissection of regulatory motifs in 2000 predicted human enhancers using a massively parallel reporter assay.

Systematic dissection of regulatory motifs in 2000 predicted human enhancers using a massively parallel reporter assay.

http://www.wikidata.org/entity/Q40174890

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Defining functional DNA elements in the human genome Synthetic biology in mammalian cells: next generation research tools and therapeutics Decoding enhancers using massively parallel reporter assays High-throughput sequencing technologies Cis-regulatory somatic mutations and gene-expression alteration in B-cell lymphomas.The appeasement of Doug: a synthetic approach to enhancer biology.A genome-integrated massively parallel reporter assay reveals DNA sequence determinants of cis-regulatory activity in neural cells Dissection of thousands of cell type-specific enhancers identifies dinucleotide repeat motifs as general enhancer features.High-throughput and quantitative assessment of enhancer activity in mammals by CapStarr-seq.High-throughput functional testing of ENCODE segmentation predictions.FunSeq2: a framework for prioritizing noncoding regulatory variants in cancer Large-scale de novo DNA synthesis: technologies and applications.Transcriptional Enhancers: Bridging the Genome and Phenome.Direct GR Binding Sites Potentiate Clusters of TF Binding across the Human Genome.Enhancer variants: evaluating functions in common disease.An atlas of active enhancers across human cell types and tissues.Enhancer evolution across 20 mammalian species.Massively parallel reporter assays in cultured mammalian cells.Psoriasis drug development and GWAS interpretation through in silico analysis of transcription factor binding sites Systematic dissection of coding exons at single nucleotide resolution supports an additional role in cell-specific transcriptional regulation.Systematic dissection of the sequence determinants of gene 3' end mediated expression control.Systematic identification of regulatory elements in conserved 3' UTRs of human transcripts Occupancy by key transcription factors is a more accurate predictor of enhancer activity than histone modifications or chromatin accessibility.Genomic perspectives of transcriptional regulation in forebrain development.Human Enhancers Are Fragile and Prone to Deactivating Mutations Understanding how cis-regulatory function is encoded in DNA sequence using massively parallel reporter assays and designed sequences.Dissecting the target specificity of RNase H recruiting oligonucleotides using massively parallel reporter analysis of short RNA motifs.Genome-wide identification of hypoxia-induced enhancer regions A method to predict the impact of regulatory variants from DNA sequence.Which Genetics Variants in DNase-Seq Footprints Are More Likely to Alter Binding?Direct Identification of Hundreds of Expression-Modulating Variants using a Multiplexed Reporter Assay.Functional genomics bridges the gap between quantitative genetics and molecular biology.LMethyR-SVM: Predict Human Enhancers Using Low Methylated Regions based on Weighted Support Vector Machines.Genome-wide mapping of autonomous promoter activity in human cells Accurate Promoter and Enhancer Identification in 127 ENCODE and Roadmap Epigenomics Cell Types and Tissues by GenoSTAN.Imputation for transcription factor binding predictions based on deep learning Promoter-distal RNA polymerase II binding discriminates active from inactive CCAAT/ enhancer-binding protein beta binding sites Common variation in atrial fibrillation: navigating the path from genetic association to mechanism.From GWAS to function: lessons from blood cells.Tissue-specific regulatory circuits reveal variable modular perturbations across complex diseases

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Systematic dissection of regulatory motifs in 2000 predicted human enhancers using a massively parallel reporter assay.

http://www.wikidata.org/entity/Q40174890

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Alexandre Melnikov

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Jason Ernst

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Jessica Alston

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Li Wang

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Peter Rogov

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Pouya Kheradpour

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Tarjei S Mikkelsen

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Xiaolan Zhang

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P2860

GENCODE: producing a reference annotation for ENCODE

Ultraconserved Elements in the Human Genome

Potential etiologic and functional implications of genome-wide association loci for human diseases and traits

A high-resolution map of human evolutionary constraint using 29 mammals

Novel repressor of the human FMR1 gene - identification of p56 human (GCC)(n)-binding protein as a Krüppel-like transcription factor ZF5

Exploiting transcription factor binding site clustering to identify cis-regulatory modules involved in pattern formation in the Drosophila genome

MONKEY: identifying conserved transcription-factor binding sites in multiple alignments using a binding site-specific evolutionary model

MUSCLE: multiple sequence alignment with high accuracy and high throughput

Systematic discovery of regulatory motifs in human promoters and 3' UTRs by comparison of several mammals

Ultraconservation identifies a small subset of extremely constrained developmental enhancers

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