The membrane anchor R7BP controls the proteolytic stability of the striatal specific RGS protein, RGS9-2.
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GPR158/179 regulate G protein signaling by controlling localization and activity of the RGS7 complexesType 5 G protein beta subunit (Gbeta5) controls the interaction of regulator of G protein signaling 9 (RGS9) with membrane anchorsThe R7 RGS protein family: multi-subunit regulators of neuronal G protein signalingCrystal structure of the multifunctional Gβ5–RGS9 complexR7BP complexes with RGS9-2 and RGS7 in the striatum differentially control motor learning and locomotor responses to cocaineD1 dopamine receptor signaling is modulated by the R7 RGS protein EAT-16 and the R7 binding protein RSBP-1 in Caenoerhabditis elegans motor neuronsThe evolution of regulators of G protein signalling proteins as drug targets - 20 years in the making: IUPHAR Review 21.RSBP-1 is a membrane-targeting subunit required by the Galpha(q)-specific but not the Galpha(o)-specific R7 regulator of G protein signaling in Caenorhabditis elegans.Targeting of RGS7/Gbeta5 to the dendritic tips of ON-bipolar cells is independent of its association with membrane anchor R7BP.Membrane anchor R9AP potentiates GTPase-accelerating protein activity of RGS11 x Gbeta5 complex and accelerates inactivation of the mGluR6-G(o) signaling.Proteomic identification of Hsc70 as a mediator of RGS9-2 degradation by in vivo interactome analysis.Nuclear localization of the G protein beta 5/R7-regulator of G protein signaling protein complex is dependent on R7 binding protein.Thinking outside of the "RGS box": new approaches to therapeutic targeting of regulators of G protein signaling.A conserved protein interaction interface on the type 5 G protein beta subunit controls proteolytic stability and activity of R7 family regulator of G protein signaling proteins.Transcriptional suppression, DNA methylation, and histone deacetylation of the regulator of G-protein signaling 10 (RGS10) gene in ovarian cancer cells.Gi/o signaling and the palmitoyltransferase DHHC2 regulate palmitate cycling and shuttling of RGS7 family-binding protein.An allosteric regulator of R7-RGS proteins influences light-evoked activity and glutamatergic waves in the inner retina.Knockout of G protein β5 impairs brain development and causes multiple neurologic abnormalities in mice.Membrane attachment is key to protecting transducin GTPase-activating complex from intracellular proteolysis in photoreceptorsOrphan Receptor GPR158 Is an Allosteric Modulator of RGS7 Catalytic Activity with an Essential Role in Dictating Its Expression and Localization in the BrainRGS9-2 modulates sensory and mood related symptoms of neuropathic pain.Lentiviral RNAi-induced downregulation of adenosine kinase in human mesenchymal stem cell grafts: a novel perspective for seizure control.GIRK channel modulation by assembly with allosterically regulated RGS proteinsThe complex of G protein regulator RGS9-2 and Gβ(5) controls sensitization and signaling kinetics of type 5 adenylyl cyclase in the striatumIntermolecular Interaction between Anchoring Subunits Specify Subcellular Targeting and Function of RGS Proteins in Retina ON-Bipolar NeuronsAssociation with the Plasma Membrane Is Sufficient for Potentiating Catalytic Activity of Regulators of G Protein Signaling (RGS) Proteins of the R7 Subfamily.Changes in striatal signaling induce remodeling of RGS complexes containing Gbeta5 and R7BP subunits.Orphan receptor GPR179 forms macromolecular complexes with components of metabotropic signaling cascade in retina ON-bipolar neuronsRetina-specific GTPase accelerator RGS11/G beta 5S/R9AP is a constitutive heterotrimer selectively targeted to mGluR6 in ON-bipolar neuronsTiming is everything: GTPase regulation in phototransduction.Structure, function, and localization of Gβ5-RGS complexes.Control of striatal signaling by g protein regulators.G protein signaling in the retina and beyond: the Cogan lectureRegulation of neurite morphogenesis by interaction between R7 regulator of G protein signaling complexes and G protein subunit Gα13.RGS9-2 Modulates Responses to Oxycodone in Pain-Free and Chronic Pain States.Nucleus accumbens-specific interventions in RGS9-2 activity modulate responses to morphine.Regulating the regulators: Epigenetic, transcriptional, and post-translational regulation of RGS proteins.RGS7 is recurrently mutated in melanoma and promotes migration and invasion of human cancer cells.A High-Throughput Time-Resolved Fluorescence Energy Transfer Assay to Screen for Modulators of RGS7/Gβ5/R7BP Complex.Genetic Analysis of Rare Human Variants of Regulators of G Protein Signaling Proteins and Their Role in Human Physiology and Disease
P2860
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P2860
The membrane anchor R7BP controls the proteolytic stability of the striatal specific RGS protein, RGS9-2.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
The membrane anchor R7BP contr ...... specific RGS protein, RGS9-2.
@en
type
label
The membrane anchor R7BP contr ...... specific RGS protein, RGS9-2.
@en
prefLabel
The membrane anchor R7BP contr ...... specific RGS protein, RGS9-2.
@en
P2093
P2860
P356
P1476
The membrane anchor R7BP contr ...... specific RGS protein, RGS9-2.
@en
P2093
Arthur Semenov
Garret R Anderson
Joseph H Song
Kirill A Martemyanov
P2860
P304
P356
10.1074/JBC.M610518200
P407
P577
2006-12-07T00:00:00Z