The Type II heat-labile enterotoxins LT-IIa and LT-IIb and their respective B pentamers differentially induce and regulate cytokine production in human monocytic cells.
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Toll-like receptor 2 mediates cellular activation by the B subunits of type II heat-labile enterotoxins.Cholera toxin, LT-I, LT-IIa and LT-IIb: the critical role of ganglioside binding in immunomodulation by type I and type II heat-labile enterotoxins.Differential binding of Escherichia coli enterotoxins LT-IIa and LT-IIb and of cholera toxin elicits differences in apoptosis, proliferation, and activation of lymphoid cells.Enhanced antigen uptake by dendritic cells induced by the B pentamer of the type II heat-labile enterotoxin LT-IIa requires engagement of TLR2.Binding to gangliosides containing N-acetylneuraminic acid is sufficient to mediate the immunomodulatory properties of the nontoxic mucosal adjuvant LT-IIb(T13I)LT-IIc, a new member of the type II heat-labile enterotoxin family encoded by an Escherichia coli strain obtained from a nonmammalian host.Importance of heat-labile enterotoxin in colonization of the adult mouse small intestine by human enterotoxigenic Escherichia coli strainsLT-IIc, a new member of the type II heat-labile enterotoxin family, exhibits potent immunomodulatory properties that are different from those induced by LT-IIa or LT-IIb.Cholera toxin impairs the differentiation of monocytes into dendritic cells, inducing professional antigen-presenting myeloid cells.Characterization of antigen-presenting cells induced by intragastric immunization with recombinant chimeric immunogens constructed from Streptococcus mutans AgI/II and type I or type II heat-labile enterotoxinsDistinctive immunomodulatory and inflammatory properties of the Escherichia coli type II heat-labile enterotoxin LT-IIa and its B pentamer following intradermal administration.AB toxins: a paradigm switch from deadly to desirableTLR2-dependent modulation of dendritic cells by LT-IIa-B5, a novel mucosal adjuvant derived from a type II heat-labile enterotoxin.Mechanisms of inflammasome activation by Vibrio cholerae secreted toxins vary with strain biotype.Cell clustering and delay/arrest in T-cell division implicate a novel mechanism of immune modulation by E. coli heat-labile enterotoxin B-subunits.Mutants of type II heat-labile enterotoxin LT-IIa with altered ganglioside-binding activities and diminished toxicity are potent mucosal adjuvants.In vitro induction of immunoglobulin A (IgA)- and IgM-secreting plasma blasts by cholera toxin depends on T-cell help and is mediated by CD154 up-regulation and inhibition of gamma interferon synthesisThe Divergent CD8+ T Cell Adjuvant Properties of LT-IIb and LT-IIc, Two Type II Heat-Labile Enterotoxins, Are Conferred by Their Ganglioside-Binding B Subunits.Immunomodulation with enterotoxins for the generation of secretory immunity or tolerance: applications for oral infections.In vivo and in vitro adjuvant activities of the B subunit of Type IIb heat-labile enterotoxin (LT-IIb-B5) from Escherichia coli.Expression and Regulation of Cholecystokinin Receptor in the Chicken's Immune Organs and Cells.Heat-labile enterotoxins as adjuvants or anti-inflammatory agents.Type II heat-labile enterotoxins: structure, function, and immunomodulatory properties.Role of virulence factors on host inflammatory response induced by diarrheagenic Escherichia coli pathotypes.Mapping of a microbial protein domain involved in binding and activation of the TLR2/TLR1 heterodimer.Peptide mapping of bacterial fimbrial epitopes interacting with pattern recognition receptors.An Enterotoxin-Like Binary Protein from Pseudomonas protegens with Potent Nematicidal Activity.Ganglioside GD1a is an essential coreceptor for Toll-like receptor 2 signaling in response to the B subunit of type IIb enterotoxin.
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The Type II heat-labile enterotoxins LT-IIa and LT-IIb and their respective B pentamers differentially induce and regulate cytokine production in human monocytic cells.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
The Type II heat-labile entero ...... tion in human monocytic cells.
@en
type
label
The Type II heat-labile entero ...... tion in human monocytic cells.
@en
prefLabel
The Type II heat-labile entero ...... tion in human monocytic cells.
@en
P2093
P2860
P1476
The Type II heat-labile entero ...... ction in human monocytic cells
@en
P2093
Hesham Nawar
Richard I Tapping
Terry D Connell
P2860
P304
P356
10.1128/IAI.72.11.6351-6358.2004
P407
P577
2004-11-01T00:00:00Z