Interdomain communication in DNA topoisomerase II. DNA binding and enzyme activation.
about
DNA cleavage and opening reactions of human topoisomerase IIα are regulated via Mg2+-mediated dynamic bending of gate-DNAToward discovering new anti-cancer agents targeting topoisomerase IIα: a facile screening strategy adaptable to high throughput platformSingle-molecule measurements of the opening and closing of the DNA gate by eukaryotic topoisomerase IIDNA topoisomerase II selects DNA cleavage sites based on reactivity rather than binding affinity.Coupling between ATP binding and DNA cleavage by DNA topoisomerase II: A unifying kinetic and structural mechanism.Chiral discrimination and writhe-dependent relaxation mechanism of human topoisomerase IIα.Analysis of the eukaryotic topoisomerase II DNA gate: a single-molecule FRET and structural perspectiveDescription of phosphate hydrolysis reactions with the Self-Consistent-Charge Density-Functional-Tight-Binding (SCC-DFTB) theory. 1. Parameterization.DNA topoisomerases: harnessing and constraining energy to govern chromosome topology.The DNA-gate of Bacillus subtilis gyrase is predominantly in the closed conformation during the DNA supercoiling reaction.DNA gyrase with a single catalytic tyrosine can catalyze DNA supercoiling by a nicking-closing mechanism.Probing the conformation of the ISWI ATPase domain with genetically encoded photoreactive crosslinkers and mass spectrometry.A unique 45-amino-acid region in the toprim domain of Plasmodium falciparum gyrase B is essential for its activity.
P2860
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P2860
Interdomain communication in DNA topoisomerase II. DNA binding and enzyme activation.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Interdomain communication in DNA topoisomerase II. DNA binding and enzyme activation.
@en
type
label
Interdomain communication in DNA topoisomerase II. DNA binding and enzyme activation.
@en
prefLabel
Interdomain communication in DNA topoisomerase II. DNA binding and enzyme activation.
@en
P2860
P356
P1476
Interdomain communication in DNA topoisomerase II. DNA binding and enzyme activation
@en
P2093
Daniel Herschlag
P2860
P304
23395-23404
P356
10.1074/JBC.M604119200
P407
P577
2006-06-16T00:00:00Z