Importance of the fourth alpha-helix within the CAP homology domain of type II topoisomerase for DNA cleavage site recognition and quinolone action.
about
A mutation in Escherichia coli DNA gyrase conferring quinolone resistance results in sensitivity to drugs targeting eukaryotic topoisomerase IIAssessing sensitivity to antibacterial topoisomerase II inhibitors.Alterations in DNA gyrase and topoisomerase IV in resistant mutants of Clostridium perfringens found after in vitro treatment with fluoroquinolones.DNA topoisomerase II selects DNA cleavage sites based on reactivity rather than binding affinity.Coupling between ATP binding and DNA cleavage by DNA topoisomerase II: A unifying kinetic and structural mechanism.Interdomain communication in DNA topoisomerase II. DNA binding and enzyme activation.The alpha4 residues of human DNA topoisomerase IIalpha function in enzymatic activity and anticancer drug sensitivity.
P2860
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P2860
Importance of the fourth alpha-helix within the CAP homology domain of type II topoisomerase for DNA cleavage site recognition and quinolone action.
description
2002 nî lūn-bûn
@nan
2002 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Importance of the fourth alpha ...... ognition and quinolone action.
@ast
Importance of the fourth alpha ...... ognition and quinolone action.
@en
type
label
Importance of the fourth alpha ...... ognition and quinolone action.
@ast
Importance of the fourth alpha ...... ognition and quinolone action.
@en
prefLabel
Importance of the fourth alpha ...... ognition and quinolone action.
@ast
Importance of the fourth alpha ...... ognition and quinolone action.
@en
P2093
P2860
P1476
Importance of the fourth alpha ...... ognition and quinolone action.
@en
P2093
Anthony Maxwell
Dirk Strumberg
Jerrylaine Walker
Jiaowang Dong
John L Nitiss
Jonathan G Heddle
Kurt W Kohn
Marc C Nicklaus
Siegfried Seeber
P2860
P304
P356
10.1128/AAC.46.9.2735-2746.2002
P407
P50
P577
2002-09-01T00:00:00Z