Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage.
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p53-induced growth arrest is regulated by the mitochondrial SirT3 deacetylaseAROS has a context-dependent effect on SIRT1SIRT1 regulates the function of the Nijmegen breakage syndrome proteinSirt1 interacts with transducin-like enhancer of split-1 to inhibit nuclear factor kappaB-mediated transcriptionSIRT4 represses peroxisome proliferator-activated receptor α activity to suppress hepatic fat oxidationTranscriptional corepressor SMILE recruits SIRT1 to inhibit nuclear receptor estrogen receptor-related receptor gamma transactivationSIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during agingNutrient-sensitive mitochondrial NAD+ levels dictate cell survivalEffect of nitroxoline on angiogenesis and growth of human bladder cancerCaloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagySirtuin functions and modulation: from chemistry to the clinicProtective effects and mechanisms of sirtuins in the nervous systemEpigenetic dysregulation in Epstein-Barr virus-associated gastric carcinoma: disease and treatmentsP53/microRNA-34-induced metabolic regulation: new opportunities in anticancer therapyEx-527 inhibits Sirtuins by exploiting their unique NAD+-dependent deacetylation mechanismThe role of p53 in cancer drug resistance and targeted chemotherapyAntidicer RNAse activity of monocyte chemotactic protein-induced protein-1 is critical for inducing angiogenesisNAD metabolism and sirtuins: metabolic regulation of protein deacetylation in stress and toxicitySynergistic interactions between HDAC and sirtuin inhibitors in human leukemia cellsResveratrol inhibits protein translation in hepatic cellsSIRT1 activators suppress inflammatory responses through promotion of p65 deacetylation and inhibition of NF-κB activityMir-34a mimics are potential therapeutic agents for p53-mutated and chemo-resistant brain tumour cellsA potent and selective small molecule inhibitor of sirtuin 1 promotes differentiation of pluripotent P19 cells into functional neuronsMammalian sirtuins: biological insights and disease relevanceSirtuins in mammals: insights into their biological functionTrans-resveratrol inhibits phosphorylation of Smad2/3 and represses FSHβ gene expression by a SirT1-independent pathway in LβT2 gonadotrope cells.Purkinje cell-specific males absent on the first (mMof) gene deletion results in an ataxia-telangiectasia-like neurological phenotype and backward walking in mice.Rejuvenating sirtuins: the rise of a new family of cancer drug targetstRNA synthetase counteracts c-Myc to develop functional vasculature.Fusaric Acid Induces DNA Damage and Post-Translational Modifications of p53 in Human Hepatocellular Carcinoma (HepG2 ) Cells.SIRT1 overexpression antagonizes cellular senescence with activated ERK/S6k1 signaling in human diploid fibroblastsPorphyrin homeostasis maintained by ABCG2 regulates self-renewal of embryonic stem cellsHypothalamic Sirt1 regulates food intake in a rodent model system.The class III histone deacetylase sirtuin 1 in immune suppression and its therapeutic potential in rheumatoid arthritis.Resveratrol regulates pathologic angiogenesis by a eukaryotic elongation factor-2 kinase-regulated pathway.Awakening p53 in senescent cells using nutlin-3.Expansion of oligodendrocyte progenitor cells following SIRT1 inactivation in the adult brain.SIRT1 regulates apoptosis and Nanog expression in mouse embryonic stem cells by controlling p53 subcellular localizationSIRT1 promotes proliferation and inhibits the senescence-like phenotype in human melanoma cells.SIRT1 ameliorates age-related senescence of mesenchymal stem cells via modulating telomere shelterin.
P2860
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P2860
Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Inhibition of SIRT1 catalytic ...... survival following DNA damage.
@en
type
label
Inhibition of SIRT1 catalytic ...... survival following DNA damage.
@en
prefLabel
Inhibition of SIRT1 catalytic ...... survival following DNA damage.
@en
P2093
P2860
P1476
Inhibition of SIRT1 catalytic ...... survival following DNA damage.
@en
P2093
Jonathan M Solomon
L Julie Huber
Peter S DiStefano
Rao Pasupuleti
Rory Curtis
Thomas McDonagh
P2860
P356
10.1128/MCB.26.1.28-38.2006
P407
P577
2006-01-01T00:00:00Z