A beta-arrestin binding determinant common to the second intracellular loops of rhodopsin family G protein-coupled receptors.
about
Atypical responsiveness of the orphan receptor GPR55 to cannabinoid ligandsA rapid and affordable screening platform for membrane protein trafficking.A functional selectivity mechanism at the serotonin-2A GPCR involves ligand-dependent conformations of intracellular loop 2The second intracellular loop of the human cannabinoid CB2 receptor governs G protein coupling in coordination with the carboxyl terminal domainPharmacosynthetics: Reimagining the pharmacogenetic approachFluorescence correlation spectroscopy, combined with bimolecular fluorescence complementation, reveals the effects of β-arrestin complexes and endocytic targeting on the membrane mobility of neuropeptide Y receptorsRegulation of GPR54 signaling by GRK2 and {beta}-arrestinBimolecular fluorescence complementation: lighting up seven transmembrane domain receptor signalling networksPharmacological characterization of GPR55, a putative cannabinoid receptorProbing the structural determinants for the function of intracellular loop 2 in structurally cognate G-protein-coupled receptors.Functional competence of a partially engaged GPCR-β-arrestin complexG Protein and β-arrestin signaling bias at the ghrelin receptor.Carboxyl-terminal and intracellular loop sites for CRF1 receptor phosphorylation and beta-arrestin-2 recruitment: a mechanism regulating stress and anxiety responsesFine-tuning serotonin2c receptor function in the brain: molecular and functional implicationsThe stem cell-expressed receptor Lgr5 possesses canonical and functionally active molecular determinants critical to β-arrestin-2 recruitment.β-Arrestin-mediated receptor trafficking and signal transductionDocking of human rhodopsin mutant (Gly90→Asp) with beta-arrestin and cyanidin 3-rutinoside to cure night blindness.Ligands and signaling proteins govern the conformational landscape explored by a G protein-coupled receptorMultiple ligand-specific conformations of the β2-adrenergic receptorSerotonin receptor signaling and regulation via β-arrestins.The β-Arrestins: Multifunctional Regulators of G Protein-coupled ReceptorsArrestin binds to different phosphorylated regions of the thyrotropin-releasing hormone receptor with distinct functional consequences.Physical interaction of calmodulin with the 5-hydroxytryptamine2C receptor C-terminus is essential for G protein-independent, arrestin-dependent receptor signaling.Triphenylmethane dye activation of beta-arrestinG protein-coupled receptor kinase-mediated phosphorylation regulates post-endocytic trafficking of the D2 dopamine receptor.Regulation of serotonin 1B receptor by glycogen synthase kinase-3.Illuminating the life of GPCRsDesensitization of human CRF2(a) receptor signaling governed by agonist potency and βarrestin2 recruitment.Neuropeptide Y receptors: ligand binding and trafficking suggest novel approaches in drug development.An Actin Network Dispatches Ciliary GPCRs into Extracellular Vesicles to Modulate Signaling.Quantitative analysis of neuropeptide Y receptor association with beta-arrestin2 measured by bimolecular fluorescence complementation.An intracellular loop 2 amino acid residue determines differential binding of arrestin to the dopamine D2 and D3 receptors.Dual role of the beta2-adrenergic receptor C terminus for the binding of beta-arrestin and receptor internalization.Disease-causing mutation in GPR54 reveals the importance of the second intracellular loop for class A G-protein-coupled receptor function.Distinct motifs of neuropeptide Y receptors differentially regulate trafficking and desensitization.Unraveling the molecular architecture of a G protein-coupled receptor/β-arrestin/Erk module complex.Crystal structure of a common GPCR-binding interface for G protein and arrestin.Differential signaling by splice variants of the human free fatty acid receptor GPR120.The arginine of the DRY motif in transmembrane segment III functions as a balancing micro-switch in the activation of the β2-adrenergic receptor.The hydrophobic amino acid cluster at the cytoplasmic end of transmembrane helix III modulates the coupling of the β(1)-adrenergic receptor to G(s).
P2860
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P2860
A beta-arrestin binding determinant common to the second intracellular loops of rhodopsin family G protein-coupled receptors.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
A beta-arrestin binding determ ...... y G protein-coupled receptors.
@en
type
label
A beta-arrestin binding determ ...... y G protein-coupled receptors.
@en
prefLabel
A beta-arrestin binding determ ...... y G protein-coupled receptors.
@en
P2093
P356
P1476
A beta-arrestin binding determ ...... y G protein-coupled receptors.
@en
P2093
Kyeong-Man Kim
Larry S Barak
Marc G Caron
Robert H Oakley
Sébastien Marion
P304
P356
10.1074/JBC.M508074200
P407
P577
2005-11-30T00:00:00Z